Alcohol and Depression among Middle-Aged and Older Adults

描述(申请人提供)：这份修订后的申请旨在前瞻性研究中老年人中的酒精和抑郁症。利用跨越时间生命研究(LAT)的母体数据，对现有的三波、10年前瞻性数据(基线和两个连续的五年随访点)进行二次数据分析。共有1,532名家长参与了至少一次的三波测试，其中80%的家长参与了2-3波测试。这些父母中有400对夫妻。申请的重点有三个方面。首先，将通过不同的统计模型(例如，潜在增长模型)研究酒精和抑郁的稳定性和变化，以评估两者如何变化，以及其中一个的变化(例如，酒精使用)是否与另一个(例如，抑郁)的变化显著相关。其次，将调查几个重要因素对酒精和抑郁的初始水平和随时间的变化的预测。这些将包括一般的应对方式(以问题为中心的应对；以情绪为中心的应对)，应对饮酒动机，以及酗酒和抑郁的家族史。第三，将调查人际因素(支持和冲突)和冲突解决方式(积极解决问题、冲突参与)与饮酒和抑郁症状轨迹以及酒精和严重抑郁障碍的关系。将进行夫妻分析，以解决婚姻二人组的类似问题，并评估婚姻伴侣中的酒精和抑郁如何影响婚姻满意度的变化。将使用一系列纵向模型(例如，双潜伏成长模型、双潜伏班级群体轨迹模型)来分析数据并评估轨迹、前置因素和结果中的性别差异。 与公共健康相关：美国的人口趋势表明，中老年人的比例正在增加，65岁的人口预计将从2000年的12.4%增加到2030年的19.6%。随着这部分人口的扩大，对医疗和公共卫生部门的需求增加，以解决包括酗酒和抑郁在内的健康问题。这一应用程序建议使用1532名成年人(包括400对夫妻)的三波、10年前瞻性数据，以评估潜在的重要可修改特征(例如，应对方式、冲突解决技能)，这些特征可前瞻性地预测酒精、抑郁及其共同发生。

DESCRIPTION (provided by applicant): This revised application seeks to prospectively study alcohol and depression among middle- aged and older adults. Secondary data analyses of extant three-wave, 10-year prospective data (baseline and two successive five-year follow-up points) from the Lives across Time (LAT) Study are proposed using the parent data from the LAT. A total of 1,532 parents participated at least once across the three-waves, with 80% participating at 2-3 waves. Among these parents are 400 marital couples. The focus of the application is threefold. First, the stability and change of alcohol and depression will be studied across time via different statistical models (e.g., latent growth models) to evaluate how both may change and if change in one (e.g., alcohol use) is significantly related to change in the other (e.g., depression). Second, several important factors will be investigated with regard to their prediction of initial levels and changes in alcohol and depression across time. These will include general coping styles (problem-focused coping; emotion-focused coping), coping drinking motives, and family history of alcoholism and depression. Third, interpersonal factors (support and conflict) and conflict resolution styles (positive problem solving, conflict engagement) will be investigated in relation to alcohol use and depressive symptom trajectories and alcohol and major depressive disorders. Couples analyses will be conducted to address similar issues for the martial dyads, as well as to evaluate how alcohol and depression among marital partners may influence changes in marital satisfaction. A range of longitudinal models (e.g., dual latent growth models, dual latent class group trajectory models) will be used to analyze the data and evaluate sex differences in trajectories, antecedents, and outcomes. PUBLIC HEALTH RELEVANCE: Demographic trends in the U.S. indicate that the proportion of middle-aged and older adults is increasing, with the population aged >65 years projected to increase from 12.4% in 2000 to 19.6% in 2030. Associated with the expansion of this segment of the population are increased demands on the medical and public health sectors to address health conditions, including alcohol use and depression. This application proposes to use three-wave, 10-year prospective data of 1,532 adults, including 400 marital couples, to evaluate potentially important modifiable characteristics (e.g., coping styles, conflict resolution skills) that prospectively predict alcohol, depression, and their co-occurrence.