The Development of Alcohol Use and Alcohol Disorders Across the Lifespan

整个生命周期中酒精使用和酒精障碍的发展

• 批准号: 8721270
• 负责人: MICHAEL T WINDLE
• 金额: $ 19.93万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-10 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8721270
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Adult; African American; Age; Alcohol Phenotype; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholic beverage heavy drinker; Alcohols; Applications Grants; Award; Behavioral Sciences; CRH gene; Child; Child Development; Chronic; Chronology; Collection; Communities; Data; Data Collection; Data Set; Development; Developmental Process; Disease; Disease susceptibility; Distal; Effectiveness; Environment; Epidemiology; Ethnic group; Etiology; Evaluation; Explosion; Faculty; Fathers; Female; Funding; Generations; Genes; Genetic; Genomics; Goals; Growth; Health; Health education; Hispanics; Human; Intervention; Knowledge; Life Cycle Stages; Light; Longevity; Longitudinal Studies; Mental disorders; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Molecular; Mothers; National Institute on Alcohol Abuse and Alcoholism; Nature; Parents; Pattern; Phenotype; Physiological; Predictive Value; Prevention; Prevention program; Psychopathology; Public Health; Publications; Publishing; Records; Research; Risk; Sampling; Science; Scientist; Self Medication; Senior Scientist; Senior Scientist Award; Spouses; Statistical Methods; Stress; Stressful Event; Techniques; Time; Time Study; Trauma; United States National Institutes of Health; Universities; Work; Writing; age group; alcohol behavior; alcohol misuse; alcohol prevention; alcohol related problem; base; behavioral health; binge drinking; craving; drinking; early adolescence; early alcohol use; early onset; emerging adulthood; environmental stressor; field study; gene environment interaction; genetic association; graduate student; interest; male; member; middle age; multilevel analysis; novel; professor; programs; prospective; racial and ethnic; repository; skills; theories; underage drinking reduction; young adult; youth violence

DESCRIPTION (provided by applicant): This is a new application for a Senior Scientist Research and Mentorship Award (K05). The applicant, Michael Windle, Rollins Endowed Professor of Public Health and Chair of the Department of Behavioral Sciences and Health Education (BSHE) at Emory University, proposes to provide mentoring to three outstanding tenure-track faculty members. Two of the applicants to be mentored are assistant professors in BSHE, and the third is from a nearby university and has been mentored by the applicant for the last three-years. All three of these mentees have excellent publication records, have published studies on alcohol and other substance use, have demonstrated interest in pursuing NIAAA R01 awards, and none has received funding at the R01 level. Two of the mentees currently have K01 awards. All three mentees have an interest in developing further their knowledge of alcohol studies, the use of advanced longitudinal statistical methods in their research, and the incorporation gene-environment (GE) relations as they prepare NIH applications. For all applicants, mentoring goals involve providing guidance and support with respect to writing competitive grant proposals, further developing the mentees' research programs, and a further focus on more general professional development, including working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. With respect to his Research Plan, the applicant proposes to continue to pursue a research program that applies a lifespan developmental psychopathology perspective in alcohol studies with particular emphasis on understanding stability and change in alcohol use and alcohol disorders across the lifespan (e.g., changes associated with transitions from adolescence to emerging adulthood to young adulthood; changes from middle-age to older adulthood), transitions in drinking status across time (e.g., light drinker to heavy drinker; heavy drinker to light drinker or abstainer), and the tme invariant and time-varying risk and protective predictors of these changes across the life course. Using several existing and ongoing longitudinal data sets, the applicant proposes to continue research on the developmental- etiologic factors that influence alcohol phenotypes across time and for different racial/ethnic groups. Specific emphasis is focused on the analyses of prospective panel data and GE relations that provide novel opportunities to study prominent developmental processes related to alcohol phenotypes in a highly refined and nuanced way that incorporates both G and E factors and their interactions as they unfold across time. Alcohol prevention programs for public health are best guided by models that ncorporate the time-changing, multiplicity of genetic (G), environmental (E) factors that underlie the etiology and time-course of alcohol misuse and alcohol disorders. A new generation of mentored scientists with the necessary skills to conduct such analyses could rapidly advance the alcohol studies field and greatly facilitate efforts to reduce underage drinking and associated adverse health consequences across the lifespan.

描述（由申请人提供）：这是高级科学家研究和指导奖（K05）的新申请。申请人迈克尔·温德尔 (Michael Windle) 是埃默里大学公共卫生学罗林斯捐赠教授兼行为科学与健康教育系 (BSHE) 系主任，他提议为三名杰出的终身教授提供指导。其中两名接受指导的申请人是 BSHE 的助理教授，第三名来自附近的一所大学，并且在过去三年中一直受到该申请人的指导。所有这三名学员都拥有出色的发表记录，发表过关于酒精和其他药物使用的研究，并表现出对追求 NIAAA R01 奖项的兴趣，并且没有人获得过 R01 级别的资助。其中两名学员目前已获得 K01 奖项。所有三位学员都有兴趣进一步发展他们的酒精研究知识、在他们的研究中使用先进的纵向统计方法，以及在准备 NIH 申请时整合基因-环境 (GE) 关系。对于所有申请人来说，指导目标包括在撰写竞争性资助提案方面提供指导和支持，进一步开发受训者的研究项目，并进一步关注更一般的专业发展，包括与受训者合作，提高他们作为研究生和博士后培训生导师的有效性。关于他的研究计划，申请人建议继续开展一项研究计划，将终生发展精神病理学视角应用于酒精研究，特别强调了解整个生命周期中酒精使用和酒精障碍的稳定性和变化（例如，与从青春期到成年初期到成年早期的转变相关的变化；从中年到老年的变化）、饮酒状态随时间的转变 （例如，少量饮酒者到大量饮酒者；大量饮酒者到少量饮酒者或戒酒者），以及这些变化在整个生命过程中的时间不变和时变风险和保护性预测因素。使用几个现有的和正在进行的纵向数据集，申请人建议继续研究影响不同时间和不同种族/族裔群体的酒精表型的发育病因学因素。具体重点是对前瞻性面板数据和 GE 关系的分析，这些分析提供了新的机会，以高度精炼和细致的方式研究与酒精表型相关的显着发育过程，其中结合了 G 和 E 因素及其随着时间的推移而展开的相互作用。公共卫生的酒精预防计划最好以模型为指导，该模型将随时间变化的遗传 (G) 和环境 (E) 因素的多样性纳入其中，这些因素是酒精滥用和酒精障碍的病因和时间过程的基础。拥有进行此类分析所需技能的新一代受指导的科学家可以迅速推进酒精研究领域，并极大地促进减少未成年人饮酒和整个生命周期相关不良健康后果的努力。