The Development of Alcohol Use and Alcohol Disorders Across the Lifespan

描述(由申请人提供)：这是一份新的高级科学家研究和导师奖的申请(K05)。申请者是罗林斯公共卫生捐赠教授、埃默里大学行为科学和健康教育系(BSHE)主任迈克尔·温德尔，他提议为三名优秀的终身教职员工提供指导。接受指导的申请者中有两人是BSHE的助理教授，第三人来自附近的一所大学，过去三年一直由申请者指导。这三名受试者都有很好的发表记录，发表了关于酒精和其他物质使用的研究，都表现出了追求NIAAA R01奖项的兴趣，没有一人获得过R01级别的资金。其中两名学员目前拥有K01奖项。所有这三名受试者都有兴趣进一步发展他们对酒精研究的知识，在他们的研究中使用先进的纵向统计方法，以及在他们准备NIH申请时纳入基因与环境(GE)的关系。对于所有申请者，指导目标包括提供关于撰写竞争性拨款提案的指导和支持，进一步发展被辅导者的研究计划，以及进一步关注更一般的职业发展，包括与被辅导者合作，了解他们作为研究生和博士后实习生导师的有效性。关于他的研究计划，申请人建议继续进行一项研究计划，在酒精研究中应用终身发展精神病理学观点，特别强调了解酒精使用和酒精障碍在整个生命周期中的稳定性和变化(例如，与从青春期到新兴成年期再到年轻成年期的转变相关的变化；从中年到老年的变化)，饮酒状态随时间的转变(例如，从饮酒者到重度饮酒者；从酗酒者到戒酒者)，以及这些变化在整个生命过程中的不变和时变的风险和保护性预测因子。利用几个现有的和正在进行的纵向数据集，申请人建议继续研究影响不同种族/民族不同时期酒精表型的发育病因因素。特别强调的是对未来面板数据和GE关系的分析，这些数据提供了新的机会，以高度精炼和细微差别的方式研究与酒精表型相关的突出发育过程，纳入G和E因素及其随着时间的推移而展开的相互作用。公共卫生的酒精预防方案最好是以模型为指导，这些模型结合了酒精滥用和酒精紊乱的病因和时间进程所依据的时变、遗传(G)、环境(E)因素。拥有进行此类分析所需技能的新一代有指导的科学家可能会迅速推动酒精研究领域的发展，并极大地促进减少未成年人饮酒及其相关的终身不良健康后果的努力。

DESCRIPTION (provided by applicant): This is a new application for a Senior Scientist Research and Mentorship Award (K05). The applicant, Michael Windle, Rollins Endowed Professor of Public Health and Chair of the Department of Behavioral Sciences and Health Education (BSHE) at Emory University, proposes to provide mentoring to three outstanding tenure-track faculty members. Two of the applicants to be mentored are assistant professors in BSHE, and the third is from a nearby university and has been mentored by the applicant for the last three-years. All three of these mentees have excellent publication records, have published studies on alcohol and other substance use, have demonstrated interest in pursuing NIAAA R01 awards, and none has received funding at the R01 level. Two of the mentees currently have K01 awards. All three mentees have an interest in developing further their knowledge of alcohol studies, the use of advanced longitudinal statistical methods in their research, and the incorporation gene-environment (GE) relations as they prepare NIH applications. For all applicants, mentoring goals involve providing guidance and support with respect to writing competitive grant proposals, further developing the mentees' research programs, and a further focus on more general professional development, including working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. With respect to his Research Plan, the applicant proposes to continue to pursue a research program that applies a lifespan developmental psychopathology perspective in alcohol studies with particular emphasis on understanding stability and change in alcohol use and alcohol disorders across the lifespan (e.g., changes associated with transitions from adolescence to emerging adulthood to young adulthood; changes from middle-age to older adulthood), transitions in drinking status across time (e.g., light drinker to heavy drinker; heavy drinker to light drinker or abstainer), and the tme invariant and time-varying risk and protective predictors of these changes across the life course. Using several existing and ongoing longitudinal data sets, the applicant proposes to continue research on the developmental- etiologic factors that influence alcohol phenotypes across time and for different racial/ethnic groups. Specific emphasis is focused on the analyses of prospective panel data and GE relations that provide novel opportunities to study prominent developmental processes related to alcohol phenotypes in a highly refined and nuanced way that incorporates both G and E factors and their interactions as they unfold across time. Alcohol prevention programs for public health are best guided by models that ncorporate the time-changing, multiplicity of genetic (G), environmental (E) factors that underlie the etiology and time-course of alcohol misuse and alcohol disorders. A new generation of mentored scientists with the necessary skills to conduct such analyses could rapidly advance the alcohol studies field and greatly facilitate efforts to reduce underage drinking and associated adverse health consequences across the lifespan.