The Development of Alcohol Use and Alcohol Disorders Across the Lifespan

描述（由申请人提供）：这是一个高级科学家研究和导师奖（K 05）的新申请。申请人，迈克尔温德尔，罗林斯捐赠的公共卫生教授和行为科学和健康教育（BSHE）在埃默里大学的系主任，建议提供指导，以三个优秀的终身教职员工。两名申请人是BSHE的助理教授，第三名来自附近的大学，在过去三年中一直由申请人指导。所有这三个学员都有出色的出版记录，发表了关于酒精和其他物质使用的研究，表现出对追求NIAAA R 01奖项的兴趣，没有一个人获得过R 01级别的资助。其中两名学员目前拥有K 01奖项。所有三名学员都有兴趣进一步发展他们对酒精研究的了解，在他们的研究中使用先进的纵向统计方法，以及在准备NIH申请时纳入基因-环境（GE）关系。对于所有申请人，指导目标涉及提供指导和支持，以撰写有竞争力的赠款提案，进一步发展学员的研究计划，并进一步关注更一般的专业发展，包括与学员合作，提高他们作为研究生和博士后学员导师的效率。关于他的研究计划，申请人建议继续进行一项研究计划，该计划在酒精研究中应用生命周期发育精神病理学观点，特别强调理解整个生命周期中酒精使用和酒精障碍的稳定性和变化（例如，与从青春期到成年初显期到青年期的转变相关的变化;从中年到老年的变化），饮酒状态随时间的转变（例如，轻度饮酒者到重度饮酒者;重度饮酒者到轻度饮酒者或戒酒者），以及这些变化在整个生命过程中的时间不变和随时间变化的风险和保护性预测因素。使用几个现有和正在进行的纵向数据集，申请人建议继续研究不同时间和不同种族/民族群体影响酒精表型的发育-病因学因素。特别强调的是集中在前瞻性面板数据和GE关系的分析，提供了新的机会，研究突出的发展过程，酒精表型在一个高度精炼和细致入微的方式，结合了G和E的因素及其相互作用，因为它们随着时间的推移展开。公共卫生的酒精预防计划最好由模型来指导，这些模型包括随时间变化的，遗传（G），环境（E）因素的多样性，这些因素是酒精滥用和酒精障碍的病因学和时间过程的基础。新一代受过指导的科学家具有进行此类分析的必要技能，可以迅速推进酒精研究领域，并大大促进减少未成年人饮酒和相关的不良健康后果的努力。

DESCRIPTION (provided by applicant): This is a new application for a Senior Scientist Research and Mentorship Award (K05). The applicant, Michael Windle, Rollins Endowed Professor of Public Health and Chair of the Department of Behavioral Sciences and Health Education (BSHE) at Emory University, proposes to provide mentoring to three outstanding tenure-track faculty members. Two of the applicants to be mentored are assistant professors in BSHE, and the third is from a nearby university and has been mentored by the applicant for the last three-years. All three of these mentees have excellent publication records, have published studies on alcohol and other substance use, have demonstrated interest in pursuing NIAAA R01 awards, and none has received funding at the R01 level. Two of the mentees currently have K01 awards. All three mentees have an interest in developing further their knowledge of alcohol studies, the use of advanced longitudinal statistical methods in their research, and the incorporation gene-environment (GE) relations as they prepare NIH applications. For all applicants, mentoring goals involve providing guidance and support with respect to writing competitive grant proposals, further developing the mentees' research programs, and a further focus on more general professional development, including working with mentees on their own effectiveness as mentors to graduate students and postdoctoral trainees. With respect to his Research Plan, the applicant proposes to continue to pursue a research program that applies a lifespan developmental psychopathology perspective in alcohol studies with particular emphasis on understanding stability and change in alcohol use and alcohol disorders across the lifespan (e.g., changes associated with transitions from adolescence to emerging adulthood to young adulthood; changes from middle-age to older adulthood), transitions in drinking status across time (e.g., light drinker to heavy drinker; heavy drinker to light drinker or abstainer), and the tme invariant and time-varying risk and protective predictors of these changes across the life course. Using several existing and ongoing longitudinal data sets, the applicant proposes to continue research on the developmental- etiologic factors that influence alcohol phenotypes across time and for different racial/ethnic groups. Specific emphasis is focused on the analyses of prospective panel data and GE relations that provide novel opportunities to study prominent developmental processes related to alcohol phenotypes in a highly refined and nuanced way that incorporates both G and E factors and their interactions as they unfold across time. Alcohol prevention programs for public health are best guided by models that ncorporate the time-changing, multiplicity of genetic (G), environmental (E) factors that underlie the etiology and time-course of alcohol misuse and alcohol disorders. A new generation of mentored scientists with the necessary skills to conduct such analyses could rapidly advance the alcohol studies field and greatly facilitate efforts to reduce underage drinking and associated adverse health consequences across the lifespan.