International Symposium on Collaterals to the Brain

描述（由申请人提供）：脑血管疾病国际研讨会是一个多学科科学会议，重点关注急性和慢性神经血管疾病的侧支灌注。该提案要求对会议提供部分支持，该会议具有广泛的长期目标，将详细介绍抵押品知识的现状，确定差距，并为该领域未来5年的研究制定路线图。指导初级研究人员在这奋进的努力是一个主要的重点，这第一次会议致力于抵押品的大脑。结肠炎最近已成为中风研究的主流焦点，但从未建立一个论坛来关注NINDS的这一最高研究优先事项。本次会议的目的是召集30多位领先的专家，以涵盖这一新兴领域的关键方面，共有200名与会者参加为期2天的学术会议。已确认的计划分为5个会议，涵盖了历史和侧支的转化研究，侧支的慢性作用，影像学特征，急性卒中方面，以及侧支治疗的临床试验设计考虑。研讨会和小组讨论 致力于指导下一代侧支灌注研究者的相关问题。出版计划包括一个详细的路线图，下一步的研究抵押品。将尽一切努力鼓励研究生和博士后的参与，使妇女人数均等，并包括少数民族和残疾人。将评估会议目标的可测量结果，评估本次研讨会对NIH对新研究者的承诺、转化性卒中研究和NINDS PRG对侧支灌注研究的优先权的影响。通过独特的活动、相关的互动和随后的路线图出版，建立了一个新的研究合作框架，培养了新的研究者，改善了该领域的临床实践，强调了这一建议的重要性。这项建议的健康相关性植根于讨论和研究计划，这将有助于解决关键优先事项的影响作用，侧枝中风的破坏性疾病。 公共卫生相关性：国际脑血管病研讨会是一个为期两天的多学科科学会议，重点是急性和慢性神经血管疾病的侧支灌注。领先的专家将评估当前关于宣传材料作用的知识，找出差距，解决这一领域未来创新者的指导问题，并发表 侧支灌注研究未来5年的详细路线图。了解侧枝循环在急性卒中和颅内狭窄中的有益作用可能会加速侧枝循环疗法的发展，以恢复卒中的血流，这是美国成人残疾的主要原因，也是改善公共卫生的关键优先事项。

DESCRIPTION (provided by applicant): The International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. This proposal requests partial support for a conference with broad, long-term objectives that will detail current status of knowledge on collaterals, identify gaps, and develop a roadmap for the next 5 years of research in this field. Mentoring junior investigators in this endeavor is a major emphasis of this first meeting devoted to collaterals to the brain. Collaterals have recently become a mainstream focus of stroke research, yet a forum has never been established to dedicate attention to this top research priority of NINDS. The aims of this conference will convene over 30 leading experts to cover critical aspects of this burgeoning field, with a total of 200 participants for a 2-day conference in an academic setting. The confirmed program is structured into 5 sessions covering the history and translational research on collaterals, chronic role of collaterals, imaging features, acute stroke aspects, and considerations of clinical trial design for collateral therapeutics. A seminar and panel discussion is devoted to issues germane to mentoring the next generation of investigators in collateral perfusion. Publication plans include a detailed roadmap on next steps in research on collaterals. Every effort will be made to encourage participation by postgraduate students and postdocs, to have parity in the numbers of women, and to include minorities and persons with disabilities. Measurable outcomes of conference goals will be assessed, evaluating the impact of this symposium on the NIH commitment to new investigators, translational stroke research and the NINDS PRG priority for studies on collateral perfusion. The significance of this proposal is underscored by the establishment of a framework for novel research collaborations, cultivation of new investigators and improved clinical practice in this area, through a unique event, associated interactions and subsequent roadmap publication. The health relatedness of this proposal is rooted in the discussions and research initiatives that will help address key prioritie on the influential role of collaterals in the devastating disorder of stroke. PUBLIC HEALTH RELEVANCE: The International Symposium on Collaterals to the Brain is a 2-day multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. Leading experts will evaluate current knowledge on the role of collaterals, identify gaps, address mentoring issues of future innovators in this area, and publish a detailed roadmap for the next 5 years of research on collateral perfusion. Understanding the beneficial effects of collaterals in acute stroke and intracranial stenoses may accelerate the development of collateral therapeutics to restore blood flow in stroke, the leading cause of adult disability in the US and a key priority for improving public health.