International Symposium on Collaterals to the Brain

大脑络脉国际研讨会

• 批准号: 8458827
• 负责人: DAVID SIGMUND LIEBESKIND
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458827
• 关键词: Acute; Acute Disease; Address; Adult; Anatomy; Area; Attention; Blood Vessels; Blood flow; Books; Brain; Brain Diseases; Cerebrovascular Circulation; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Collaborations; Collateral Circulation; Development; Diagnosis; Disabled Persons; Disease; Education; Ensure; Evaluation; Event; Fertilization; Functional disorder; Future; Genetic; Goals; Health; Hemorrhage; Image; Infarction; Influentials; International; Ischemia; Ischemic Stroke; Journals; Knowledge; Mainstreaming; Measurable; Mentors; Methodology; Minority; National Institute of Neurological Disorders and Stroke; Outcome; Participant; Perfusion; Plant Roots; Postdoctoral Fellow; Prevention; Progress Review Group; Public Health; Publications; Publishing; Questionnaires; Recording of previous events; Request for Proposals; Research; Research Personnel; Research Priority; Risk; Role; Stenosis; Stroke; Structure; Students; Therapeutic; Translational Research; United States National Institutes of Health; Woman; Work; acute stroke; base; brain tissue; career; clinical practice; design; disability; hemodynamics; improved; innovation; insight; interdisciplinary approach; lectures; meetings; multidisciplinary; next generation; novel; outcome forecast; parity; programs; stroke recovery; success; symposium

DESCRIPTION (provided by applicant): The International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. This proposal requests partial support for a conference with broad, long-term objectives that will detail current status of knowledge on collaterals, identify gaps, and develop a roadmap for the next 5 years of research in this field. Mentoring junior investigators in this endeavor is a major emphasis of this first meeting devoted to collaterals to the brain. Collaterals have recently become a mainstream focus of stroke research, yet a forum has never been established to dedicate attention to this top research priority of NINDS. The aims of this conference will convene over 30 leading experts to cover critical aspects of this burgeoning field, with a total of 200 participants for a 2-day conference in an academic setting. The confirmed program is structured into 5 sessions covering the history and translational research on collaterals, chronic role of collaterals, imaging features, acute stroke aspects, and considerations of clinical trial design for collateral therapeutics. A seminar and panel discussion is devoted to issues germane to mentoring the next generation of investigators in collateral perfusion. Publication plans include a detailed roadmap on next steps in research on collaterals. Every effort will be made to encourage participation by postgraduate students and postdocs, to have parity in the numbers of women, and to include minorities and persons with disabilities. Measurable outcomes of conference goals will be assessed, evaluating the impact of this symposium on the NIH commitment to new investigators, translational stroke research and the NINDS PRG priority for studies on collateral perfusion. The significance of this proposal is underscored by the establishment of a framework for novel research collaborations, cultivation of new investigators and improved clinical practice in this area, through a unique event, associated interactions and subsequent roadmap publication. The health relatedness of this proposal is rooted in the discussions and research initiatives that will help address key prioritie on the influential role of collaterals in the devastating disorder of stroke. PUBLIC HEALTH RELEVANCE: The International Symposium on Collaterals to the Brain is a 2-day multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. Leading experts will evaluate current knowledge on the role of collaterals, identify gaps, address mentoring issues of future innovators in this area, and publish a detailed roadmap for the next 5 years of research on collateral perfusion. Understanding the beneficial effects of collaterals in acute stroke and intracranial stenoses may accelerate the development of collateral therapeutics to restore blood flow in stroke, the leading cause of adult disability in the US and a key priority for improving public health.

描述（由申请人提供）：大脑侧枝循环国际研讨会是一次多学科科学会议，重点关注急性和慢性神经血管疾病的侧枝循环灌注。该提案要求对具有广泛、长期目标的会议提供部分支持，该会议将详细介绍抵押品知识的现状，找出差距，并为该领域未来 5 年的研究制定路线图。指导初级研究人员从事这项工作是第一次专门讨论大脑循环问题的会议的一个主要重点。抵押品最近已成为卒中研究的主流焦点，但从未建立一个论坛来专门关注 NINDS 的这一首要研究重点。本次会议的目标是聚集 30 多名领先专家，涵盖这一新兴领域的关键方面，共有 200 名与会者参加为期 2 天的学术会议。已确认的计划分为 5 个会议，涵盖络合物的历史和转化研究、络合物的慢性作用、影像学特征、急性中风方面以及络合物治疗临床试验设计的考虑因素。研讨会和小组讨论 致力于研究与指导下一代侧支灌注研究人员密切相关的问题。出版计划包括抵押品研究后续步骤的详细路线图。将尽一切努力鼓励研究生和博士后的参与，实现女性人数均等，并包容少数民族和残疾人。将评估会议目标的可衡量成果，评估本次研讨会对 NIH 对新研究者、转化性卒中研究和 NINDS PRG 侧支灌注研究优先事项的承诺的影响。通过独特的活动、相关的互动和随后的路线图发布，建立了新的研究合作框架、培养新的研究人员并改进了该领域的临床实践，强调了该提案的重要性。该提案与健康的相关性植根于讨论和研究举措，这些讨论和研究举措将有助于解决循环在毁灭性中风疾病中的影响作用的关键优先事项。 公共健康相关性：大脑侧支循环国际研讨会是一个为期 2 天的多学科科学会议，重点关注急性和慢性神经血管疾病的侧支循环灌注。领先的专家将评估当前关于抵押品作用的知识，找出差距，解决该领域未来创新者的指导问题，并发布 未来 5 年侧枝灌注研究的详细路线图。了解侧枝循环对急性中风和颅内狭窄的有益作用可能会加速侧枝疗法的开发，以恢复中风中的血流，中风是美国成人残疾的主要原因，也是改善公众健康的关键优先事项。