Modeling of Collateral Perfusion in the Ischemic Brain

项目摘要/摘要 常见的神经疾病造成了日益沉重的公共卫生负担，需要研究 以患者为中心的研究(POR)研究人员的潜在机制和充分的努力。这是职业生涯中期 应用的长期指导计划的目标是培养来自不同领域的领先的年轻翻译科学家 POR中的神经学子专业，弥补威胁未来的神经学POR中的指导缺口 进展，长期研究项目的目标是增加对卒中侧支循环灌注的了解。 建议为选定的住院医师、临床研究员和初级教员提供创新的指导基础设施 神经学子专业的内容导师和整体POR导师。指导目标包括1) 建立部门指导基础设施、一对一指导、学员研究、职业生涯 开发和网站资源；2)开设神经病学、临床和翻译研究的新课程 和科学交流；以及3)不断提高教师指导技能。这件事的影响 加州大学洛杉矶分校的指导计划将通过具体的结果措施进行跟踪，以确保学员的成就 和总体计划里程碑。这个K24奖项将有助于实现部门的长期目标，以增强 跨神经学子专业，建立正式的神经学POR导师关系，激发独立性 研究学员，培养鼓舞人心的智力环境，以增加未来神经病学的数量 POR调查员。这种神经学POR培训的综合方法也受益于一项重点研究 为卒中的内容指导开发侧支循环灌流模型的策略，该项目提供 指导各种POR技术的机会。新型神经影像和血管造影术 将使用各种方法来开发和验证使用压力的侧支循环灌注的区域模型。 动脉、组织和静脉的差异预测急性脑缺血患者的组织命运和神经预后 卒中。这项在卒中护理中一个重要主题的临床相关工作将增强对络脉的理解 脑血流灌注，包括动脉段和静脉段对脑循环的不同贡献。在……里面 除了促进科学知识和提供指导机会外，一个切实的 由此产生的产品将成为一种软件工具，用于增强对急性心肌梗塞患者组织命运和神经预后的预测 中风引起脑缺血的原因多种多样。

PROJECT SUMMARY/ABSTRACT Common neurological disorders pose an increasingly formidable public health burden that requires studies of underlying mechanisms and ample effort of patient-oriented research (POR) investigators. This midcareer application's long-term mentoring program goal is to train leading young translational scientists from diverse neurologic subspecialties in POR, redressing the mentoring gap in neurology POR that threatens future progress, and the long-term research project goal is to increase understanding of collateral perfusion in stroke. An innovative mentoring infrastructure for selected residents, clinical fellows and junior faculty is proposed with content mentors in neurologic subspecialties and an overall POR mentor. Mentoring aims include 1) establishing departmental mentoring infrastructure, one-on-one mentoring, trainee research, career development and website resources; 2) creating new courses on neurology clinical and translational research and scientific communications; and 3) continually enhancing faculty mentorship skills. The impact of this mentoring program at UCLA will be tracked with specific outcome measures to ensure achievement of trainee and overall program milestones. This K24 award will help achieve departmental long-term goals to enhance POR across neurologic subspecialties, establish formal neurology POR mentorship, stimulate independent research of trainees and foster an inspiring intellectual environment to increase the number of future neurology POR investigators. This integrated approach to neurology POR training also benefits from a focused research strategy to develop a model of collateral perfusion for content mentoring in stroke, a project that provides mentoring opportunities over a diverse spectrum of POR techniques. Novel neuroimaging and angiography approaches will be used to develop and validate a regional model of collateral perfusion using pressure differentials in arteries, tissue, and veins to predict tissue fate and neurological outcomes in acute ischemic stroke. This clinically relevant work on an important topic in stroke care will enhance understanding of collateral perfusion, including the distinct contributions of arterial and venous segments of the cerebral circulation. In addition to the advancement of scientific knowledge and provision of mentoring opportunities, a tangible resulting product will be a software tool to enhance prediction of tissue fate and neurological outcomes in acute stroke across diverse causes of brain ischemia.