2nd International Symposium on Collaterals to the Brain

描述（由申请人提供）：第二届脑侧支循环国际研讨会是一个多学科的科学会议，重点是急性和急性脑梗死患者的侧支循环灌注， 慢性神经血管疾病该提案要求对具有广泛长期目标的会议给予部分支持，该会议将推进当前关于侧支灌注的研究，确定差距并就与卒中侧支相关的关键主题发表共识声明。指导初级研究人员在这奋进的努力是这个独特的会议致力于抵押品的大脑的主要重点。脑的侧支灌注现在被认为是中风风险、缺血性梗死和再灌注损伤（包括出血性转化、恢复和几乎每种急性和慢性脑缺血性疾病的临床结果）的基本决定因素。该论坛的建立是为了关注NINDS的这一最高研究优先事项。本次会议的目的是召集48位顶尖专家就这一新兴领域的关键方面进行辩论，共有400名与会者参加为期2天的学术会议。确认的程序是结构成12个一小时的辩论主题的逆向工程抵押品，赞同系统生物学的方法。由2名专家组成的小组将采用公共论坛辩论形式，有条不紊地达成共识，最终发表关于侧支灌注研究的详细共识声明。一个关于反向指导的主持晚宴研讨会将反映整个研讨会期间讨论的6个主题，由6名获得旅行奖学金提名的初级研究人员参加。将尽一切努力鼓励研究生和博士后的参与，使妇女人数均等，并包括少数民族和残疾人。将评估会议目标的可测量结果，评估本次研讨会对NIH对新研究者的承诺、转化性卒中研究和NINDS PRG对侧支灌注研究的优先权的影响。通过独特的活动、相关的互动和随后发表的共识声明，培养新的研究合作框架、指导新的研究人员和改善这一领域的临床实践，强调了这一提议的重要性。该提案的健康相关性植根于讨论和研究举措，这些讨论和研究举措解决了中风这一毁灭性疾病中侧枝循环的影响作用的关键优先事项。

DESCRIPTION (provided by applicant): The 2nd International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. This proposal requests partial support for a conference with broad, long-term objectives that will advance current research on collateral perfusion, identify gaps and produce a consensus statement on critical topics related to collaterals in stroke. Mentoring junior investigators in this endeavor is a major emphasis of this unique meeting devoted to collaterals to the brain. Collateral perfusion of the brain is now recognized as a fundamental determinant of stroke risk, ischemic infarction, and reperfusion injury including hemorrhagic transformation, recovery and clinical outcome in virtually every acute and chronic ischemic disorder of the brain. This forum has been established to devote attention to this top research priority of NINDS. The aims of this conference will convene over 48 leading experts to debate critical aspects of this burgeoning field, with a total of 400 participants for a 2-day conference in an academic setting. The confirmed program is structured into 12 one-hour debate topics on reverse engineering collaterals, endorsing a systems biology approach. Public forum debate format will be utilized by teams of 2 experts to methodically reach consensus, culminating with publication of a detailed consensus statement on research in collateral perfusion. A moderated dinner seminar on reverse mentoring will reflect upon the 6 themes addressed throughout the symposium, covered by 6 junior investigators nominated for travel scholarships. Every effort will be made to encourage participation by postgraduate students and postdocs, to have parity in the numbers of women, and to include minorities and persons with disabilities. Measurable outcomes of conference goals will be assessed, evaluating the impact of this symposium on the NIH commitment to new investigators, translational stroke research and the NINDS PRG priority for studies on collateral perfusion. The significance of this proposal is underscored by the cultivation of a framework for novel research collaborations, mentoring of new investigators and improved clinical practice in this area, through a unique event, associated interactions and subsequent publication of a consensus statement. The health relatedness of this proposal is rooted in the discussions and research initiatives that address key priorities on the influential role of collaterals in the devastating disorder of stroke.