8th International Symposium on Collaterals to the Brain

项目概要/摘要 第八届国际脑血管病研讨会是一个多学科的科学会议，重点是缺血性中风的侧支循环。该提案要求部分支持一个具有广泛长期目标的会议，该会议将推进当前关于侧支血流的研究，并确定世界各地当前治疗策略的差距。侧支或抵消脑缺血的个体能力以及有利侧支概况的确定已成为考虑脑缺血和中风精确医学的关键因素，从而驱动个体化医疗决策。该会议直接解决了最紧迫的问题和最佳定义限制世界各地实现中风治疗的侧支状态的差距。决定性的挑战包括基于侧支状态的最佳分诊和选择范例的普遍性，用于缺血性卒中的确定性治疗，专家方法和变革性进展的快速传播，以及迫切需要利用与脑侧支血流动力学相关的卒中教育和科学的网络机会。本次会议的目的是召集来自世界各地的教师，将最先进设施的现场参与者与超过75个国家和地区的远程观众联系起来。详细的演讲主题围绕着与基础科学、转化、临床研究、常规临床方面、成像、血管内治疗和大脑中侧枝血管的护理问题有关的主题进行了安排。这个为期3天的会议的确认程序被组织成40分钟的会议，专门讨论在地球仪中翻译中风治疗中的collaterome的关键问题。特别重要的是，将根据基于国家的年度调查，介绍在卒中中使用血流动力学的周期进展。辩论，解决方案，早期职业和基础科学主持的海报会议，动手神经血管设备研讨会和穿插的网络机会的专门会议将加强在这个新兴领域的合作举措。与以往会议一样，电子海报、会议记录和其他出版物的快速传播将加强这一独特而受人尊敬的年度研讨会的影响。已经为适当的代表性作出了专门努力，以实现妇女人数的均等，征聘代表性不足的少数民族和残疾人，最终使参与者的范围极其多样化。为当地代表人数不足的少数群体颁发培训人员奖，将显著增强这次会议的教育影响。可衡量的结果将量化本次研讨会对NINDS使命的影响，以提高对侧支循环的认识，减少中风引起的神经系统疾病的负担。这个独特的专业论坛从世界各地的最先进的场地延伸，强调了抵押品在巨大规模上的及时影响，鼓励最大程度的参与，快速传播和网络资源的附加值。

PROJECT SUMMARY/ABSTRACT The 8th International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral circulation in ischemic stroke. This proposal requests partial support for a conference with broad, long-term objectives that will advance current research on collateral blood flow and identify gaps in current treatment strategies around the world. The collaterome, or individual capacity to offset ischemia in the brain, and determination of a favorable collateral profile have become pivotal factors in the consideration of cerebral ischemia and the precision medicine of stroke driving individualized medical decision-making. The conference directly addresses the most pressing issues and gaps in optimally defining collateral status that limits the realization of stroke therapies around the world. Decisive challenges include generalizability of optimal triage and selection paradigms based on collateral status for definitive treatment of ischemic stroke, rapid dissemination of expert methods and transformative advances, and the urgent need to leverage networking opportunities for stroke education and science related to hemodynamics of collaterals to the brain. The aims of this conference will convene faculty from around the world to connect on-site participants at the state-of-the-art facility with remote audiences in more than 75 countries and regions. Detailed presentation topics have been arranged around themes relating to the basic science, translational, clinical research, routine clinical aspects, imaging, endovascular therapy, and systems of care issues of collaterals in the brain. The confirmed program of this 3-day conference is structured into 40-minute sessions devoted to key issues in translating the collaterome in stroke therapy across the globe. Of particular importance is the interval progress on the use of hemodynamics in stroke that will be presented based on the annual country-based surveys. The dedicated sessions for debates, solutions, and the early career and basic science moderated poster session, hands-on neurovascular device workshop and interspersed networking opportunities will enhance collaborative initiatives in this burgeoning field. Rapid dissemination of electronic posters, proceedings, and other publications, as in past meetings, will intensify the impact of this unique and esteemed annual Symposium. Dedicated efforts for appropriate representation have already been delineated to have parity in the numbers of women, recruit underrepresented minorities and persons with disabilities, culminating in an extremely diverse spectrum of participants. Trainee awards for underrepresented minorities from the local region will markedly enhance the educational impact of this meeting. Measurable outcomes will quantify the impact of this symposium on the NINDS mission to enhance knowledge of collaterals and reduce the burden of neurological disease due to stroke. This unique forum of expertise extending from a state-of-the-art venue across the world emphasizes the timely impact of collaterals on a monumental scale, encouraging maximal participation, rapid diffusion, and added value of networking resources.