SNRP Program at UCC

UCC 的 SNRP 项目

• 批准号: 8485965
• 负责人: MARIA BYKHOVSKAIA
• 金额: $ 13.45万
• 依托单位: UNIVERSIDAD CENTRAL DEL CARIBE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8485965
• 关键词: Address; Biological Factors; Cocaine; Collaborations; Funding; Hippocampus (Brain); Huntington Disease; Institutes; Institution; Journals; Manuscripts; Marines; Mediating; N-Methylaspartate; Nicotine; Nicotinic Antagonists; Nicotinic Receptors; Norepinephrine; Peer Review; Positioning Attribute; Potassium Channel; Prefrontal Cortex; Process; Publishing; Puerto Rican; Reporting; Research; Research Personnel; Scientist; Signal Transduction Pathway; Slice; Spermine; Synapses; Thyroid Hormones; Tobacco; Travel; United States National Institutes of Health; Universities; Washington; excitotoxicity; neuroprotection; noradrenergic; oxidative damage; programs; receptor; transmission process

DESCRIPTION (provided by applicant): The SNRP-1 Program at UCC is centered around three research topics: norepinephrine modulation of sensitization to cocaine, neuroprotection by nicotine and tobacco cembranoids, and cembranoid mechanism of action on nicotinic receptors. A Natural Products Core provides tobacco and marine cembranoids, both known and new. Each project is performed in collaboration with a collaborator from a research-intensive institution: UCLA, Cornell U. (Ithaca) and the Vollum Institute (OHSU). SNRP-1 was funded since October 1999. Four RO1 proposals were presented to the NIH during the third year, three of which are now in the process of re-submission. Thirty nine manuscripts were published in peer-reviewed journals. Among the scientific discoveries reported, we would like to mention the following: 1) Noradrenergic transmission through alpha-2 receptors mediates some of the inhibitory effects of cocaine in the prefrontal cortex. 2) Both nicotine and tobacco cembranoids protect the hippocampal slice from NMDA-induced excitotoxicity, but the signal transduction pathways are different. 3) Cembranoids are nicotinic antagonists whose inhibitory action can be released by certain cocaine derivatives. We now propose to continue this successful program for a second cycle of five years. Three new scientists will address the issues of oxidative damage in Huntington disease, direct effects of thyroid hormones on the nAChR and on synapse remodelling, and modulation of potassium channels by spermine. Collaborators are from Washington University and UCLA. Program activities include seminars, courses, travel, etc. A transition plan from SNRP-1 to RO1 funding, is proposed for the present investigators. A plan to attract Puerto Rican Ph.Ds to postdoctoral positions with SNRP scientists at UCC is also presented.

描述（由申请人提供）：UCC 的 SNRP-1 项目围绕三个研究主题：去甲肾上腺素对可卡因致敏的调节、尼古丁和烟草西松烷的神经保护作用以及西松烷对烟碱受体的作用机制。 天然产品核心提供烟草和海洋西松烷内酯，包括已知的和新的。 每个项目都是与来自研究密集型机构的合作者合作执行的：加州大学洛杉矶分校、康奈尔大学（伊萨卡）和沃勒姆研究所（OHSU）。 SNRP-1 自 1999 年 10 月起获得资助。第三年向 NIH 提交了四份 RO1 提案，其中三份目前正在重新提交过程中。 三十九篇手稿发表在同行评审期刊上。 在所报告的科学发现中，我们想提及以下内容：1) 通过 α-2 受体的去甲肾上腺素能传递介导可卡因在前额皮质中的一些抑制作用。 2）尼古丁和烟草西松烷类化合物都能保护海马片免受NMDA诱导的兴奋性毒性，但信号转导途径不同。 3)西松烷类是烟碱拮抗剂，其抑制作用可由某些可卡因衍生物释放。我们现在建议将这一成功的计划继续进行第二个五年周期。 三位新科学家将解决亨廷顿病中的氧化损伤、甲状腺激素对 nAChR 和突触重塑的直接影响以及精胺对钾通道的调节等问题。 合作者来自华盛顿大学和加州大学洛杉矶分校。 计划活动包括研讨会、课程、旅行等。为目前的研究人员提出了从 SNRP-1 到 RO1 资助的过渡计划。 还提出了一项吸引波多黎各博士到 UCC SNRP 科学家担任博士后职位的计划。

项目成果

Horseradish peroxidase as a reporter gene and as a cell-organelle-specific marker in correlative light-electron microscopy.

辣根过氧化物酶作为报告基因和相关光电子显微镜中的细胞器特异性标记。

• DOI: 10.1007/978-1-60761-783-9_25
• 发表时间: 2010
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Schikorski,Thomas

Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia.

• DOI: 10.1016/j.neuroscience.2015.02.001
• 发表时间: 2015-04-16
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Martins, A. H.;Hu, J.;Xu, Z.;Mu, C.;Alvarez, P.;Ford, B. D.;El Sayed, K.;Eterovic, V. A.;Ferchmin, P. A.;Hao, J.
• 通讯作者: Hao, J.