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Language in Primary Progressive Aphasia

原发性进行性失语症的语言

基本信息

批准号：
8292779
负责人：
MAREK-MARSEL M MESULAM
金额：
$ 60.95万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-05 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8292779
关键词：
Address Alzheimer&apos s Disease American Anomia Anterior Aphasia Architecture Area Atrophic Attention Biological Markers Biometry Brain Diseases Broca&apos s area Cerebrum Characteristics Collaborations Competence Comprehension Dementia Deposition Development Diagnosis Disease Enrollment Event-Related Potentials Evolution Eye Movements Fostering Frequencies Frontotemporal Lobar Degenerations Funding Geographic Distribution Goals Grant Heterogeneity Impairment International Investigation Language Language Disorders Learning Left Longitudinal Studies Magnetic Resonance Memory Methodology Modality Names Neurobiology Neurodegenerative Disorders Neuropsychology Participant Pathology Patients Phenotype Physics Primary Progressive Aphasia Process Productivity Recovery Recruitment Activity Registries Reporting Research Research Personnel Resources Retrieval Risk Factors Schedule Semantics Services Site Staging Structure Syndrome Tauopathies Temporal Lobe Travel Universities Variant Visit base cerebral atrophy cohort data sharing design follow-up interdisciplinary approach interest international center multidisciplinary neurobehavior neuroimaging neuropathology novel programs protein TDP-43 research study web site

项目摘要

DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a brain disease that causes a gradual and increasingly more debilitating impairment of word usage and comprehension. Although it is being recognized with increasing frequency, PPA remains underserved with respect to research and patient services. This application seeks continued funding for a project that is the centerpiece of a comprehensive PPA Research Program at Northwestern University. The goal is to make maximal use of a unique cohort that has been recruited during the first 5 years of the project and to enroll new patients for hypothesis-driven investigations of naming, word comprehension, incidental memory and sentence processing with novel tasks designed by a multidisciplinary team of investigators with a track record of close collaboration and high productivity in PPA. We believe that this type of research program can best be achieved within the structure of a multidisciplinary approach such as the one we have established for this purpose, led by researchers in neuroimaging (Dr. Emily Rogalski), neurolinguistics (Dr. Cynthia Thompson), event-related potentials (Dr. Ken Paller), neuropsychology (Dr. Sandra Weintraub), neurobehavior (Dr. Marsel Mesulam), biostatistics (Dr. Alfred Rademaker) and Magnetic Resonance physics (Dr. Todd Parrish). For the next cycle, we chose specific aims that address the four core themes of this project: subtyping and temporal evolution of PPA, mechanisms of naming and semantic distortions, characteristics of fluency and grammatical competence, and anatomical substrates of language as inferred from the distribution of peak atrophy sites in patients. Within this framework, our primary aims will be 1. To complete a longitudinal study of a select subset of current participants in order to delineat the natural course of PPA and to characterize the evolution of its initial stages (Experiment 1). 2 To clarify the mechanisms of anomia with a cross-modal ERP experiment (Experiment 2). 3. To investigate dynamic perturbations of verb and sentence processing with on-line tasks using the methodology of ERP and eye movement recording (Experiments 3 and 4). 4. To identify the anatomical basis of material- and modality-specific distortions of learning in PPA (Experiment 5). 5. To foster the continued development of the International PPA Connection (IMPPACT) website, launched through the American Recovery and Reinvestment Act (ARRA), as an international collaborative patient and resource registry (ppaconnection.org). PUBLIC HEALTH RELEVANCE: Primary progressive aphasia (PPA) is a brain disease that causes a gradual and increasingly more debilitating impairment of word usage and comprehension. Although it is being recognized with increasing frequency, PPA remains underserved with respect to research and patient services. This application seeks continued funding for a project that is the centerpiece of a comprehensive PPA Research Program at Northwestern University.

描述（由申请人提供）：原发性进行性失语症（PPA）是一种大脑疾病，导致逐渐和越来越衰弱的文字使用和理解障碍。虽然PPA越来越多地得到认可，但在研究和患者服务方面仍然服务不足。该申请旨在为西北大学综合PPA研究计划的核心项目提供持续资金。目标是最大限度地利用在项目前5年招募的独特队列，并招募新患者进行命名，单词理解，附带记忆和句子处理的假设驱动调查，由多学科研究人员团队设计的新任务，具有密切合作和PPA高生产力的记录。我们相信，这种类型的研究计划最好是在多学科方法的结构内实现，例如我们为此目的建立的，由神经影像学研究人员领导的方法。（艾米丽罗加尔斯基博士），神经语言学（辛西娅·汤普森博士），事件相关电位（Ken Paller博士）、神经心理学（Sandra Weintraub博士）、神经行为学（Marsel Mesulam博士）、生物统计学（Alfred Rademaker博士）和磁共振物理学（托德帕里什博士）。对于下一个周期，我们选择了具体的目标，解决这个项目的四个核心主题：PPA的亚型和时间演变，命名和语义扭曲的机制，流畅性和语法能力的特点，以及从患者峰值萎缩部位的分布推断的语言的解剖学基础。在此框架内，我们的主要目标是1。完成一个选定的子集的当前参与者的纵向研究，以描绘在PPA的自然过程，并表征其初始阶段的演变（实验1）。2.通过跨通道ERP实验（实验2）探讨命名障碍的发生机制。3.本研究采用ERP和眼动记录的方法，考察了动词和句子加工的动态扰动。4.识别PPA中学习的材料和模式特异性扭曲的解剖学基础（实验5）。5.促进通过《美国复苏和再投资法案》（ARRA）启动的国际PPA连接（IMPPACT）网站的持续发展，作为国际合作患者和资源登记处（ppaconnection.org）。公共卫生关系：原发性进行性失语症（PPA）是一种大脑疾病，它会导致词汇使用和理解能力逐渐减弱。虽然PPA越来越多地得到认可，但在研究和患者服务方面仍然服务不足。该申请旨在为西北大学综合PPA研究计划的核心项目提供持续资金。