Language in Primary Progressive Aphasia

原发性进行性失语症的语言

• 批准号: 9916775
• 负责人: MAREK-MARSEL M MESULAM
• 金额: $ 62.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9916775
• 关键词: Achievement; Address; Adult; Alzheimer' s Disease; Anatomy; Anomia; Anterior; Autopsy; Biologic Characteristic; Biometry; Brain; Categories; Cessation of life; Clinical; Clinical Trials; Collaborations; Communication; Communities; Complex; Comprehension; Dementia; Development; Diagnosis; Diagnostic; Disease; Educational Materials; Enrollment; Experimental Designs; Family; Fingerprint; Funding; Genetic; Image; Impairment; Inferior; Inferior frontal gyrus; Intervention; Investigation; Language; Left; Lobule; Location; Magnetic Resonance Imaging; Medical; Metabolic; Modality; Names; Neuroanatomy; Neurodegenerative Disorders; Neuropsychology; Onset of illness; Parietal; Pathologist; Patients; Play; Positron-Emission Tomography; Primary Progressive Aphasia; Production; Research; Research Personnel; Rest; Risk Factors; Role; Specialized Center; Speech; Structure; Structure of middle temporal gyrus; Supervision; Syndrome; Temporal Lobe; Therapeutic Trials; Work; clinically relevant; cognitive neuroscience; cohort; design; experience; experimental study; frontotemporal degeneration; improved; insight; interest; language impairment; longitudinal course; molecular imaging; neuropathology; next generation; programs; recruit; stroke-induced aphasia; student training; visual tracking; volunteer

Primary progressive aphasia (PPA) is an adult onset disease that selectively attacks the left hemisphere language network. Despite considerable progress in this field, patients with PPA and their families remain underserved. Accurate medical diagnosis can be challenging outside of specialized centers, relevant educational materials are scarce, few speech and language pathologists in the community are equipped to provide informed interventions, and many patients tend to be excluded from clinical trials because the complex relationship to underlying neuropathology is not fully appreciated. This proposal comes from a team of investigators with a primary focus on PPA. It seeks to pursue a research program that is now in its 10th year and that has recruited nearly 150 patients for longitudinal investigation. As a consequence of the proposed work we expect to sharpen our understanding of lexicosemantic and grammatical impairments experienced by the patient, obtain new insights into the organization of the left-hemisphere language network, clarify the diagnostic fingerprints of PPA caused by Alzheimer’s disease versus frontotemporal degenerations, and increase the precision with which we can trace the temporal trajectory of the disease. The work will also continue to generate collateral benefits in the form of new educational materials for patients and families, improved recognition of the syndrome, potentially greater access of PPA patients to relevant clinical trials, and the training of students and fellows who will develop into the next generation of clinicians and investigators serving the needs of patients with PPA.

原发性进行性失语症（PPA）是一种选择性攻击左半球语言网络的成人发病疾病。尽管在这一领域取得了相当大的进展，但PPA患者及其家属仍然得不到充分的服务。在专业中心之外，准确的医学诊断可能具有挑战性，相关的教育材料稀缺，社区中很少有言语和语言病理学家能够提供知情的干预措施，许多患者往往被排除在临床试验之外，因为与潜在神经病理学的复杂关系没有得到充分认识。该提案来自一个主要关注PPA的调查团队。它寻求进行一项研究计划，该计划现已进入第10个年头，并招募了近150名患者进行纵向调查。作为拟议的工作的结果，我们希望加深我们的理解患者所经历的词汇语义和语法障碍，获得新的见解组织的左半球语言网络，澄清诊断指纹的PPA所造成的阿尔茨海默氏症与额颞叶退化，并提高精度，我们可以跟踪的时间轨迹的疾病。这项工作还将继续产生附带利益，为患者和家庭提供新的教育材料，提高对综合征的认识，可能使PPA患者更容易获得相关临床试验，并培训学生和研究员，他们将发展成为下一代临床医生和研究人员，为PPA患者的需求服务。