Language in Primary Progressive Aphasia

原发性进行性失语症的语言

• 批准号: 7850270
• 负责人: MAREK-MARSEL M MESULAM
• 金额: $ 20.63万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850270
• 关键词: Address; Adult; Alzheimer' s Disease; Aphasia; Area; Attention; Autopsy; Behavior; Biometry; Brain; Brain Injuries; Catchment Area; Categories; Cerebrum; Classification; Clinic; Clinic Visits; Clinical; Cognitive; Collaborations; Collection; Complex; Country; DNA; Data Base Management; Degenerative Disorder; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Electrophysiology (science); Event-Related Potentials; Funding; Future; Goals; Image; Investigation; Knowledge; Language; Language Disorders; Letters; Linguistics; Literature; Memory impairment; Methods; Modality; Molecular; Molecular Genetics; Names; Neuroanatomy; Neurobiology; Neurocognitive; Neurodegenerative Disorders; Neurologic; Neurology; Neurons; Neuropsychology; Onset of illness; Participant; Patients; Primary Progressive Aphasia; Process; Psycholinguistics; Qualifying; Recruitment Activity; Relative (related person); Reporting; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Schedule; Semantics; Seminal; Services; Source; Specialized Center; Specificity; Speech Pathology; Staging; Stroke; Structure; Symptoms; Syndrome; Therapeutic; Therapeutic Intervention; Travel; Visit; Word Processing; Work; aphasic; base; cerebrovascular lesion; interdisciplinary approach; lexical retrieval; morphometry; neurobehavior; neuroimaging; neuron loss; novel; phonology; programs; research study

DESCRIPTION (provided by applicant): The goal of the project is to investigate the language disorder and treatment modalities in primary progressive aphasia (PPA). The approach is multidiscipiinary and will include experts in neurology, speech pathology, neuropsychology, electrophysiology and imaging. The methods will include chronometric neurolinguistic investigations, event-related potentials, voxel based morphometry and diffusion tensor imaging. Several reasons justify a research program focusing on PPA. First, PPA constitutes the only adult-onset disease that selectively attacks the language network in the brain. Second, PPA patients suffer from aphasic disturbances that deserve to be characterized more fully, especially since the early stages of the disease are compatible with effective therapeutic interventions. Third, the slow dissolution of language abilities in PPA offers a unique setting, not duplicated by any other aphasic disturbance, for investigating the neurocognitive organization of language. Fourth, the relative scarcity of PPA patients, the temporal progression of the disease, and the wide catchment area needed to recruit a sufficient number of patients create a situation where the integrated work of a multidiscipiinary team is the most efficient way to conduct a research program focusing on this syndrome. The proposal comes from a team of investigators who have worked on PPA for many years and have collaborated extensively. The patients will be recruited from a clinic that is one of the world's most readily recognized referral centers for PPA. The work will use the resources of the Northwestern Alzheimer's Disease Center in a way that will enhance economy of effort.

描述(由申请人提供)：该项目的目标是调查原发性进行性失语症(PPA)的语言障碍和治疗方式。这种方法是多学科的，将包括神经学、言语病理学、神经心理学、电生理学和成像方面的专家。这些方法将包括计时神经语言学调查、事件相关电位、基于体素的形态测量和扩散张量成像。有几个理由证明了专注于PPA的研究计划是合理的。首先，PPA是唯一一种选择性攻击大脑语言网络的成人发病疾病。其次，PPA患者患有失语障碍，应该更充分地描述这些障碍的特征，特别是因为疾病的早期阶段与有效的治疗干预是兼容的。第三，PPA中语言能力的缓慢分解为研究语言的神经认知组织提供了一个独特的环境，这是任何其他失语症都无法比拟的。第四，PPA患者的相对稀缺性，疾病的时间进展，以及招募足够数量的患者所需的广泛收集区域，创造了这样一种情况，即多学科团队的综合工作是实施专注于这种综合征的研究计划的最有效方式。该提案来自一组调查人员，他们在PPA方面工作多年，并进行了广泛的合作。这些患者将从一家诊所招募，该诊所是世界上最容易被认可的PPA转诊中心之一。这项工作将以一种提高工作经济性的方式使用西北阿尔茨海默病中心的资源。