Language in Primary Progressive Aphasia

原发性进行性失语症的语言

• 批准号: 8656321
• 负责人: MAREK-MARSEL M MESULAM
• 金额: $ 62.3万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-05 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8656321
• 关键词: Address; Alzheimer' s Disease; American; Anomia; Anterior; Aphasia; Architecture; Area; Atrophic; Attention; Biological Markers; Biometry; Brain Diseases; Broca' s area; Cerebrum; Characteristics; Collaborations; Competence; Comprehension; Dementia; Deposition; Development; Diagnosis; Disease; Enrollment; Event-Related Potentials; Evolution; Eye Movements; Fostering; Frequencies; Frontotemporal Lobar Degenerations; Funding; Geographic Distribution; Goals; Grant; Heterogeneity; Impairment; International; Investigation; Language; Language Disorders; Learning; Left; Longitudinal Studies; Magnetic Resonance; Memory; Methodology; Modality; Names; Neurobiology; Neurodegenerative Disorders; Neuropsychology; Participant; Pathology; Patients; Phenotype; Physics; Primary Progressive Aphasia; Process; Productivity; Recovery; Recruitment Activity; Registries; Reporting; Research; Research Personnel; Resources; Retrieval; Risk Factors; Schedule; Semantics; Services; Site; Staging; Structure; Syndrome; Tauopathies; Temporal Lobe; Travel; Universities; Variant; Visit; base; cerebral atrophy; cohort; data sharing; design; follow-up; interdisciplinary approach; interest; international center; multidisciplinary; neurobehavior; neuroimaging; neuropathology; novel; programs; protein TDP-43; research study; web site

DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a brain disease that causes a gradual and increasingly more debilitating impairment of word usage and comprehension. Although it is being recognized with increasing frequency, PPA remains underserved with respect to research and patient services. This application seeks continued funding for a project that is the centerpiece of a comprehensive PPA Research Program at Northwestern University. The goal is to make maximal use of a unique cohort that has been recruited during the first 5 years of the project and to enroll new patients for hypothesis-driven investigations of naming, word comprehension, incidental memory and sentence processing with novel tasks designed by a multidisciplinary team of investigators with a track record of close collaboration and high productivity in PPA. We believe that this type of research program can best be achieved within the structure of a multidisciplinary approach such as the one we have established for this purpose, led by researchers in neuroimaging (Dr. Emily Rogalski), neurolinguistics (Dr. Cynthia Thompson), event-related potentials (Dr. Ken Paller), neuropsychology (Dr. Sandra Weintraub), neurobehavior (Dr. Marsel Mesulam), biostatistics (Dr. Alfred Rademaker) and Magnetic Resonance physics (Dr. Todd Parrish). For the next cycle, we chose specific aims that address the four core themes of this project: subtyping and temporal evolution of PPA, mechanisms of naming and semantic distortions, characteristics of fluency and grammatical competence, and anatomical substrates of language as inferred from the distribution of peak atrophy sites in patients. Within this framework, our primary aims will be 1. To complete a longitudinal study of a select subset of current participants in order to delineat the natural course of PPA and to characterize the evolution of its initial stages (Experiment 1). 2 To clarify the mechanisms of anomia with a cross-modal ERP experiment (Experiment 2). 3. To investigate dynamic perturbations of verb and sentence processing with on-line tasks using the methodology of ERP and eye movement recording (Experiments 3 and 4). 4. To identify the anatomical basis of material- and modality-specific distortions of learning in PPA (Experiment 5). 5. To foster the continued development of the International PPA Connection (IMPPACT) website, launched through the American Recovery and Reinvestment Act (ARRA), as an international collaborative patient and resource registry (ppaconnection.org).

描述（由申请人提供）：原发性进行性失语症（PPA）是一种脑部疾病，会导致词汇使用和理解能力逐渐减弱。尽管越来越多的人认识到PPA，但在研究和患者服务方面仍然服务不足。本申请为西北大学PPA综合研究项目的核心项目寻求持续资助。目标是最大限度地利用项目前5年招募的独特队列，并招募新患者进行假设驱动的命名，单词理解，偶然记忆和句子处理研究，这些研究任务由多学科研究小组设计，具有密切合作和高生产力的PPA记录。我们相信，这种类型的研究项目可以在多学科方法的结构中最好地实现，比如我们为此目的建立的多学科方法，由神经影像学（艾米丽·罗加斯基博士）、神经语言学（辛西娅·汤普森博士）、事件相关潜能学（肯·帕勒博士）、神经心理学（桑德拉·温特劳布博士）、神经行为学（马塞尔·梅苏拉姆博士）、生物统计学（阿尔弗雷德·拉德梅克博士）和磁共振物理学（托德·派瑞什博士）的研究人员领导。对于下一个周期，我们选择了具体的目标来解决这个项目的四个核心主题：PPA的亚型和时间演变，命名和语义扭曲的机制，流畅性和语法能力的特征，以及从患者峰值萎缩部位的分布推断的语言的解剖学基础。在这个框架内，我们的主要目标是1。为了描述PPA的自然过程并描述其初始阶段的演变特征（实验1），完成一项选择当前参与者的纵向研究。2通过跨模态ERP实验阐明异常的机制（实验2）。使用ERP和眼动记录的方法研究在线任务中动词和句子加工的动态扰动（实验3和4）。目的：确定PPA中材料和模式特异性学习扭曲的解剖学基础（实验5）。促进国际PPA连接（IMPPACT）网站的持续发展，该网站通过美国复苏和再投资法案（ARRA）启动，作为一个国际合作的患者和资源登记处（ppaconnection.org）。