2012 DNA Damage, Mutation & Cancer GRC

2012 DNA 损伤、突变

• 批准号: 8249703
• 负责人: Karen M Vasquez
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-28 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249703
• 关键词: Address; Area; Award; Biology; Bypass; California; Cancer Etiology; Cells; Chromatin; Collaborations; DNA; DNA Damage; DNA Repair Disorder; DNA Repair Pathway; DNA Structure; DNA lesion; Funding; Future; Genetic; Genomic Instability; Goals; Human; Knowledge; Lead; Lesion; Malignant Neoplasms; Mediating; Mission; Molecular; Mutagenesis; Mutation; National Institute of Environmental Health Sciences; Oral; Participant; Pathway interactions; Process; Public Health; Research; Research Personnel; Scientist; Source; Syndrome; Thinking; Time; Underrepresented Minority; United States National Institutes of Health; Woman; Work; abstracting; anticancer research; base; cancer therapy; design; graduate student; improved; meetings; multidisciplinary; planetary Atmosphere; posters; prevent; repaired; symposium; telomere

DESCRIPTION (provided by applicant): Human cells are constantly exposed to both exogenous and endogenous sources of DNA damage that lead to mutations, which can result in cancer. The overall goal of the 2012 DNA Damage, Mutation & Cancer Gordon Research Conference is to understand how mutations lead to human cancer. This is relevant to the mission of the NIH, and in particular the NCI, and NIEHS in that we aim to understand how DNA damage leads to mutations that result in human cancer, in an effort to improve strategies to prevent and treat human cancer. This goal will be achieved by organizing and hosting a multidisciplinary conference designed to address diverse research areas focused on DNA damage, mechanisms of mutagenesis and genetic instability, and the relationships between genetic instability and human cancer. Cutting edge research will be presented on the molecular mechanisms involved in the repair and processing of DNA lesions, genome instability, and cancer etiology. Topics to be covered include DNA structure and mutagenic mechanisms, telomere biology and genetic instability, DNA repair deficiency syndromes and cancer, pathways for damage repair or tolerance through lesion bypass, chromatin-mediated genomic instability, and promising strategies for targeting DNA repair pathways in cancer therapy. Junior investigators will be afforded the opportunity to present their work both by oral presentations and poster presentations. For example, of the 32 invited speakers, 5 are junior investigators. We will select (from the abstracts) an additional 14 speakers based on the most timely, and exciting work described in the abstracts. We expect that the scientific exchange at the conference will impact cancer research in significant ways and result in establishing new multi-disciplinary collaborative efforts. The 2012 DNA Damage, Mutation & Cancer Gordon Research Conference will be held in Ventura Beach, California from March 25-30, 2012. Awarded funding support for the meeting is critically necessary in order to achieve the goals set forth for the conference. Funding priorities will be for speakers who would otherwise be unable to participate in the meeting, junior investigator speakers, and to encourage the participation of women and underrepresented minorities. PUBLIC HEALTH RELEVANCE: In human cells, the DNA is constantly under attack by DNA damaging agents that can cause DNA damage that leads to mutations, which are involved in cancer etiology. The overall goal of the 2012 DNA Damage, Mutation & Cancer Gordon Research Conference is to understand how mutations lead to human cancer. This is relevant to public health because we aim to understand how DNA damage leads to mutations that result in human cancer, in an effort to improve strategies to prevent and treat human cancer.

描述（由申请人提供）：人类细胞持续暴露于导致突变的外源性和内源性DNA损伤源，这可能导致癌症。2012年DNA损伤、突变和癌症戈登研究会议的总体目标是了解突变如何导致人类癌症。这与NIH的使命有关，特别是NCI和NIEHS，因为我们的目标是了解DNA损伤如何导致导致人类癌症的突变，以努力改善预防和治疗人类癌症的策略。这一目标将通过组织和主办一个多学科会议来实现，该会议旨在解决不同的研究领域，重点是DNA损伤，诱变和遗传不稳定性的机制，以及遗传不稳定性和人类癌症之间的关系。前沿研究将在DNA损伤，基因组不稳定性和癌症病因学的修复和处理所涉及的分子机制。将涵盖的主题包括DNA结构和诱变机制，端粒生物学和遗传不稳定性，DNA修复缺陷综合征和癌症，损伤修复或通过病变旁路耐受的途径，染色质介导的基因组不稳定性，以及针对癌症治疗中的DNA修复途径的有前途的策略。初级研究人员将有机会通过口头报告和海报展示来介绍他们的工作。例如，在32名受邀发言者中，有5名是初级调查员。我们将根据摘要中描述的最及时、最令人兴奋的工作选择（从摘要中）另外14位演讲者。 我们希望会议上的科学交流将对癌症研究产生重大影响，并导致建立新的多学科合作努力。2012年DNA损伤、突变和癌症戈登研究会议将于2012年3月25日至30日在加州文图拉海滩举行。为会议提供资金支持是实现会议目标的关键。资助的优先事项将是那些否则无法参加会议的发言者、初级调查员发言者，并鼓励妇女和代表人数不足的少数群体参加会议。 公共卫生相关性：在人类细胞中，DNA不断受到DNA损伤剂的攻击，这些DNA损伤剂可导致DNA损伤，从而导致突变，这与癌症病因学有关。2012年DNA损伤、突变和癌症戈登研究会议的总体目标是了解突变如何导致人类癌症。这与公共卫生有关，因为我们的目标是了解DNA损伤如何导致导致人类癌症的突变，以改善预防和治疗人类癌症的策略。