Sleep Loss, Trait Anxiety and Emotional Brain Reactivity

睡眠不足、特质焦虑和大脑情绪反应

• 批准号: 8338270
• 负责人: Andrea Goldstein-Piekarski
• 金额: $ 3.45万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2014-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8338270
• 关键词: Acute; Affect; Affective; Amygdaloid structure; Anxiety; Anxiety Disorders; Aversive Stimulus; Behavior assessment; Brain; Brain imaging; Clinical; Comorbidity; Crossover Design; Development; Electroencephalography; Emotional; Emotions; Equilibrium; Evaluation; Event; Exhibits; Frequencies; Functional Magnetic Resonance Imaging; High Prevalence; Impairment; Individual; MRI Scans; Measures; Medial; Mood Disorders; Participant; Population; Prefrontal Cortex; Public Health; REM Sleep; Recovery; Regulation; Relative (related person); Research; Rest; Role; Signal Transduction; Sleep; Sleep Deprivation; Societies; Stimulus; Testing; Therapeutic; Time; cost; density; deprivation; effective therapy; expectation; experience; frontal lobe; innovation; prevent; relating to nervous system; research study; response; restoration; sleep abnormalities; trait

DESCRIPTION (provided by applicant): Anxiety disorders are among the most frequently occurring psychiatric conditions in the population, and are associated with serious personal and societal costs. While anxiety has independently been associated with significant sleep disruption and dysfunctional emotional brain regulation, the interaction amongst these three factors is poorly understood. Characterizing this interactive association may offer the potential not only to gain a deeper understanding of the pathophysiological mechanisms underlying anxiety, but also aid in the development of preventative strategies and effective treatments for the amelioration of anxiety. These proposed experiments combine functional MRI (fMRI), high-density sleep EEG recordings and behavioural assessments to test the hypotheses that high anxiety status (a) predisposes individuals to the deleterious effects of sleep deprivation and (b) subsequently negates the restorative benefit of recovery sleep on emotional brain reactivity, following deprivation. Considering the continued erosion of sleep time across society and the high prevalence of anxiety disorders, understanding the causal associations between anxiety, sleep impairment, and emotional brain reactivity has considerable therapeutic, clinical and public health ramifications.

描述（由申请人提供）：焦虑症是人群中最常见的精神疾病之一，与严重的个人和社会成本相关。虽然焦虑与严重的睡眠中断和情绪大脑调节功能障碍有关，但这三个因素之间的相互作用却知之甚少。表征这种交互关联可能不仅提供了对焦虑潜在的病理生理机制的更深入理解，而且还有助于制定预防策略和改善焦虑的有效治疗方法。这些拟议的实验联合收割机了功能性磁共振成像（fMRI），高密度睡眠脑电图记录和行为评估，以测试以下假设：高度焦虑状态（a）使个体容易受到睡眠剥夺的有害影响，（B）随后否定了恢复睡眠对情绪大脑反应的恢复性益处。考虑到整个社会睡眠时间的持续侵蚀和焦虑症的高患病率，了解焦虑，睡眠障碍和情绪大脑反应之间的因果关系具有相当大的治疗，临床和公共卫生影响。