The Utility of Threat Detection in Generalized Social Anxiety Disorder

威胁检测在广泛性社交焦虑症中的效用

• 批准号: 8309931
• 负责人: Spencer Lynn
• 金额: $ 38.67万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8309931
• 关键词: Affective; Age; Anger; Anxiety; Anxiety Disorders; Behavior; Behavioral; Behavioral Symptoms; Brain; Classification; Clinical Research; Cognitive; Cognitive Therapy; Conflict (Psychology); Costs and Benefits; Decision Making; Detection; Development; Disease; Distress; Economics; Emotional; Emotions; Evaluation; Event; Exhibits; Face; Facial Expression; Failure; Fright; Gender; Generalized Anxiety Disorder; Impairment; Individual; Instruction; Intervention; Judgment; Laboratories; Lead; Learning; Left; Measures; Methods; Modeling; Mood Disorders; Nature; Noise; Participant; Pathway interactions; Patients; Pattern; Perception; Perceptual learning; Performance; Persons; Population; Process; Recruitment Activity; Relative (related person); Reporting; Research; Research Personnel; Risk; Sensory; Series; Signal Detection Analysis; Signal Transduction; Social Interaction; Stimulus; Symptoms; Therapeutic Intervention; Uncertainty; base; classical conditioning; disorder control; follow-up; heuristics; improved; insight; mathematical model; novel; novel strategies; research study; social; stem; theories

DESCRIPTION (provided by applicant): During social interactions, we look into the face of another person and in the blink of an eye infer that person's emotional state and their intentions. These perceptions inform decisions about what to do or say next. Generalized Social Anxiety Disorder (GSAD) is characterized by exaggerated concerns about negative evaluation and rejection in social situations. These symptoms have been quantified with signal detection theory (SDT). The application of SDT has led to novel approaches within anxiety research; a primary hypothesis, supported by several studies, has been that the "over-reactive" nature of the anxious state can be characterized as a bias to respond to or remember situations as more threatening than they in fact are. In spite of SDT's power, its conventional use has been limited to simply quantifying differences in sensitivity, bias, and accuracy among perceivers. Left unanswered are questions of particular relevance to research and treatment: what causes the observed differences in bias and sensitivity? A critical barrier to answering this question is the current understanding of SDT in clinical research, which lacks a framework to predict or explain behavior, or in which to pose experimental questions about how mood and anxiety disorders influence the underlying mechanisms involved in threat perception. To bridge this barrier, we introduce a mathematical model of perceptual decision making that incorporates key insights from behavioral economics-utility and optimality- into a signal detection framework. Our primary objective is to use this novel framework to explain differences in threat perception among individuals with GSAD, anxious controls with generalized anxiety disorder (GAD), and non-psychiatrically-ill participants. Our secondary objective is to assess whether our framework could be used to improve interventions to reduce misperceptions of threat in GSAD. Our model is a unique conceptualization of perception (e.g., optimal detection, subjective miscalibration to underlying environmental parameters that influence overt behavior) that could eventually lead to improvements in cognitive-behavioral therapies by tailoring them to a patient's individual perceptual decision-making impairment. To achieve our aims, we will recruit 100 individuals with GSAD and 100 individuals each from age- and gender-matched GAD and healthy populations. Participants will complete a suite of perceptual tasks to isolate which of several perceptual decision parameters cause misperceptions of social threat in GSAD. Successful characterization of GSAD along such lines will take the field in new directions by framing social threat perception as a decision made by attempting to optimize detection in the presence ambiguous sensory information and conflicting, risky consequences. As well, the novel theoretical developments represented by our model will broaden SDT's usefulness deepening the insights it affords into the nature of cognitive processes.

描述（由申请人提供）：在社会交往中，我们看着另一个人的脸，一眨眼的功夫就推断出那个人的情绪状态和他们的意图。这些感知为下一步做什么或说什么的决定提供了信息。广泛性社交焦虑症（GSAD）的特征是对社交场合中的负面评价和拒绝的过度关注。这些症状已经用信号检测理论（SDT）量化。SDT的应用导致了焦虑研究中的新方法;几项研究支持的一个主要假设是，焦虑状态的“过度反应”性质可以被描述为对比实际情况更具威胁性的情况做出反应或记住的偏见。尽管SDT的权力，其传统的使用已被限制在简单地量化感知器之间的灵敏度，偏差和准确性的差异。与研究和治疗特别相关的问题没有得到回答：是什么导致了观察到的偏倚和敏感性的差异？回答这个问题的一个关键障碍是目前临床研究中对SDT的理解，它缺乏一个框架来预测或解释行为，或者在其中提出有关情绪和焦虑症如何影响威胁感知所涉及的潜在机制的实验问题。为了弥合这一障碍，我们引入了一个数学模型的感知决策，结合了关键的见解，从行为经济学的效用和最优性到信号检测框架。我们的主要目标是使用这个新的框架来解释GSAD个体，广泛性焦虑症（GAD）焦虑控制者和非精神病患者之间的威胁感知差异。我们的次要目标是评估我们的框架是否可以用来改善干预措施，以减少对GSAD威胁的误解。我们的模型是感知的独特概念化（例如，最佳检测、对影响明显行为的潜在环境参数的主观误校准），这可能最终通过使认知行为疗法适应患者的个体感知决策障碍而导致认知行为疗法的改进。为了实现我们的目标，我们将招募100名GSAD患者，并从年龄和性别匹配的GAD和健康人群中各招募100名患者。参与者将完成一套感知任务，以隔离几个感知决策参数导致GSAD中的社会威胁的误解。沿着这样的路线成功的GSAD的表征将采取新的方向，通过框架的社会威胁感知作为一个决定，试图优化检测存在模糊的感官信息和冲突，危险的后果。此外，我们的模型所代表的新的理论发展将扩大SDT的有用性，深化它提供的认知过程的性质的见解。