Mayo Clinic Center for Translational Science Activities

梅奥诊所转化科学活动中心

• 批准号: 8233598
• 负责人: ROBERT A. RIZZA
• 金额: $ 170.73万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8233598
• 关键词: Address; Advisory Committees; Basic Science; Behavioral; Benchmarking; Bioinformatics; Biology; Biometry; Caring; Center for Translational Science Activities; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Commit; Communities; Community Health; Consultations; Development; Education; Educational Curriculum; Electronics; Ensure; Ethics; Evaluation; Feasibility Studies; Fostering; Goals; Health; Health Services Research; Home environment; Human; Informatics; Instruction; Interdisciplinary Study; Investigation; Knowledge; Learning; Measures; Medical Informatics; Medical Research; Medicine; Mentors; Methodology; Methods; Mission; Outcome; Patient Care; Patients; Phase; Pilot Projects; Practice based research; Process; Program Evaluation; Provider; Research; Research Design; Research Ethics; Research Personnel; Resources; Schools; Services; Speed; Staging; Structure; Students; System; Time; Training; Training and Education; Translating; Translational Research; Translations; Vision; Work; base; behavioral/social science; biomedical informatics; career development; clinical epidemiology; clinical practice; college; comparative effectiveness; cost; design; effectiveness research; electronic data; experience; health care delivery; health disparity; improved; innovation; multidisciplinary; next generation; novel; programs; skills; social; social science research; tool

The overall goal of the Mayo Clinic CTSA is to continue to build a broad-based and integrated home for clinical and translational science (CTS) at Mayo Clinic that will ultimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same time a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal: Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both investigators and support staff. Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) continued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatistics, and ethics support for investigators, and c) further integration of support services. Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, communityengaged research and translating comparative effectiveness research into clinical practice. Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quotient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigation. Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies. Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informatics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultation and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformatics services and capabilities that will help facilitate the application of the "new biology" to clinical and translational investigation. This vision is entirely consistent with the stated mission of Mayo Clinic: "To provide the best care to every patient every day through integrated clinical practice, education, and research."

梅奥诊所CTSA的总体目标是继续建立一个基础广泛的综合家庭

项目成果

Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial.

• DOI: 10.1089/acm.2008.0402
• 发表时间: 2009-05
• 期刊: Journal of alternative and complementary medicine (New York, N.Y.)
• 作者: Thompson MA;Bauer BA;Loehrer LL;Cha SS;Mandrekar JN;Sood A;Wahner-Roedler DL
• 通讯作者: Wahner-Roedler DL

Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study.

• DOI: 10.1186/s12891-016-1375-2
• 发表时间: 2017-01-14
• 期刊: BMC musculoskeletal disorders
• 影响因子: 2.3
• 作者: Singh JA;Noorbaloochi S;Knutson KL
• 通讯作者: Knutson KL

Cardiac and thromboembolic complications and mortality in patients undergoing total hip and total knee arthroplasty.

• DOI: 10.1136/ard.2010.148726
• 发表时间: 2011-12
• 期刊: Annals of the rheumatic diseases
• 影响因子: 27.4
• 作者: Singh JA;Jensen MR;Harmsen WS;Gabriel SE;Lewallen DG
• 通讯作者: Lewallen DG

A report of the autonomic symptom profile in patients with fibromyalgia.

纤维肌痛患者自主神经症状的报告。

• DOI: 10.1097/rhu.0b013e3182a225dd
• 发表时间: 2014
• 期刊: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
• 作者: Vincent,Ann;McAllister,SamanthaJ;Singer,Wolfgang;Toussaint,LorenL;Sletten,DavidM;Whipple,MaryO;Low,PhillipA
• 通讯作者: Low,PhillipA

Getting physicians to open the survey: little evidence that an envelope teaser increases response rates.

让医生打开调查：几乎没有证据表明信封预告片可以提高回复率。

• DOI: 10.1186/1471-2288-12-41
• 发表时间: 2012
• 期刊: BMC medical research methodology
• 影响因子: 4
• 作者: Ziegenfuss,JeanetteY;Burmeister,Kelly;James,KatherineM;Haas,Lindsey;Tilburt,JonC;Beebe,TimothyJ
• 通讯作者: Beebe,TimothyJ