CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8365032
• 负责人: ROBERT A. RIZZA
• 金额: $ 10.69万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365032
• 关键词: Acquired Immunodeficiency Syndrome; Center for Translational Science Activities; Clinic; Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The overall goal of the Mayo Clinic CTSA is to continue to build a broad-based and integrated home for clinical and translational science (CTS) at Mayo Clinic that will ultimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same time a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal: Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both investigators and support staff. Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) continued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatistics, and ethics support for investigators, and c) further integration of support services. Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, community- engaged research and translating comparative effectiveness research into clinical practice. Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quotient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigation. Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies. Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informatics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultation and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformatics services and capabilities that will help facilitate the application of the "new biology" to clinical and translational investigation. This vision is entirely consistent with the stated mission of Mayo Clinic: "To provide the best care to every patient every day through integrated clinical practice, education, and research." PUBLIC HEALTH RELEVANCE (provided by applicant): Mayo Clinic Center for Translational Science Activities will bring together all the resources of the five schools within the Mayo Clinic College of Medicine and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools, and patient care practices that impact both our local and national communities by improving their health.

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 描述（由申请人提供）：马约诊所CTSA的总体目标是继续在马约诊所建立一个基础广泛的综合性临床和转化科学（CTS）之家，最终改善人类健康。在这种情况下，我们寻求使马约CTSA及其利用的资源成为临床和转化研究的效率引擎，同时成为创新的驱动力。我们还寻求将我们的地方活动与旨在协调和统一的整个财团的努力相结合。为了实现我们的目标，我们有六个首要的具体目标，为这次更新：目标1 -培训和保持优秀的多学科临床和转化科学的劳动力。这支队伍包括调查员和支助人员。目标2 -消除翻译工作的障碍。这将通过以下方式实现：a）继续努力精简监管和合规性，B）为研究者提供出色的设计、生物统计学和伦理支持，以及c）进一步整合支持服务。目标3 -与提供者和社区合作，改善医疗服务和社区健康。这包括对基于实践的研究、社区参与的研究以及将比较有效性研究转化为临床实践的实质性承诺。目标4 -部署先进的设施和其他核心资源，以提高临床研究的价值。在这种情况下，价值被定义为质量和成本的商数，目标是提高质量，降低成本，并为临床和转化研究的全方位提供资源。目标5 -通过有针对性地支持创新试点和可行性研究，促进新方法的发展，激励新的研究方向和方法。目的6 -利用信息学整合和促进临床和翻译研究。这包括信息学的广泛观点，包括：a）为CTS开发标准化的电子数据采集和分析工具，B）利用马约对电子临床系统的承诺，为医学信息学提供强大的咨询和工具，以及c）有助于促进“新生物学”应用于临床和转化研究的生物信息学服务和能力。这一愿景完全符合马约诊所的既定使命：“通过综合临床实践、教育和研究，每天为每位患者提供最好的护理。" 公共卫生相关性（申请人提供）：马约诊所转化科学活动中心将汇集马约诊所医学院内五所学校的所有资源和100多年的科学和医学研究专业知识，以发现创新的新方法，加快将研究成果转化为治疗，工具，和病人护理实践，通过改善他们的健康来影响我们的地方和国家社区。