Nuclear Receptors in Liver Health and Disease

肝脏健康和疾病中的核受体

• 批准号: 8701308
• 负责人: HARTMUT W. JAESCHKE
• 金额: $ 201.55万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701308
• 关键词: Academic Medical Centers; Achievement; Advisory Committees; Amino Acids; Applications Grants; Area; Award; Bile Acids; Biomedical Research; Centers of Research Excellence; Chemicals; Cholesterol; Coagulation Process; Core Facility; Development; Diet; Disease; Educational process of instructing; Ensure; Environment; Equipment; Evaluation Research; Faculty; Fatty acid glycerol esters; Fostering; Funding; Glucose; Goals; Grant; Health; Histopathology; Individual; Interdisciplinary Study; Kansas; Lipids; Liver; Liver Dysfunction; Manuscripts; Medical center; Mentors; Methodology; Nuclear Receptors; Peer Review; Pharmaceutical Preparations; Program Research Project Grants; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Scientist; Talents; Time; Training; United States National Institutes of Health; Universities; Vitamins; Work; Writing; absorption; cohort; experience; interest; liver function; liver repair; member; programs; statistics; sugar; symposium

Five years of funding are requested to further develop a Center of Biomedical Research Excellence at Kansas University Medical Center with a focus on Nuclear Receptors and their Role in Liver Health and Disease. Five talented new faculty who share this research interest were selected with the goal of helping them become funded, independent investigators. A PI, co-PI, an internal advisory committee of experienced senior faculty and an external advisory committee of prominent scientists have been assembled to mentor them to this goal. The Center will also help provide infrastructure and equipment to supplement the research environment. Ultimately, through the achievement of these initial goals, the final long-range goal is the submission of a program project grant application. An important feature of this Proposal is that for each initial junior faculty member, two co-mentors have been assigned and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research project by the mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing, and teaching. The first 6 junior faculty assigned to this COBRE have competed successfully for independent NIH R01-type research support. The same is expected of the present junior faculty. Once the present junior faculty are funded externally, they will financially rotate off the grant to make room for addition of new junior faculty members. Another important feature of the Proposal is to maintain 4 research Cores to provide additional research support for the Center's faculty. These cores include an administrative Core as well as Cores in the areas of biospecimen, histopathology, analytical, and sequencing. In summary, the outstanding combination of scientific talent, existing research environment, and new core facilities ensure that this proposed Center will further foster the development of a thematic multidisciplinary research center, to enhance the ability of new investigators to compete independently for complementary NIH and other external peer-reviewed support, and to strengthen existing biomedical research infrastructure at KUMC.

需要五年的资金来进一步发展堪萨斯大学医学中心的生物医学研究卓越中心，重点研究核受体及其在肝脏健康和疾病中的作用。选择了五位有共同研究兴趣的才华横溢的新教师，目的是帮助他们成为受资助的独立研究人员。 PI、联合PI、由经验丰富的高级教师组成的内部咨询委员会和由杰出科学家组成的外部咨询委员会已经成立，以指导他们实现这一目标。该中心还将帮助提供基础设施和设备来补充研究环境。最终，通过实现这些初始目标，最终的长期目标是提交计划项目拨款申请。该提案的一个重要特点是，为每位初始初级教员分配了两名共同导师，并制定了个人指导计划和时间表。指导计划的核心特征包括导师和 IAC 对研究项目的持续批判性评估、与 EAC 成员举行的半年度会议，以及统计、手稿和资助写作以及教学方面的特殊培训。分配到该 COBRE 的首批 6 名初级教师已成功竞争独立 NIH R01 型研究支持。对目前的初级教师也有同样的期望。一旦现有的初级教师获得外部资助，他们将从财务上轮流拨款，为新的初级教师的增加腾出空间。该提案的另一个重要特点是保留 4 个研究核心，为中心的教师提供额外的研究支持。这些核心包括管理核心以及生物样本、组织病理学、分析和测序领域的核心。总而言之，科学人才、现有研究环境和新核心设施的出色结合确保了该拟建中心将进一步促进专题多学科研究中心的发展，增强新研究人员独立竞争 NIH 和其他外部同行评审支持的能力，并加强 KUMC 现有的生物医学研究基础设施。