Developmental Core

发展核心 以下各节介绍了我们今后五年的主要发展活动。 8.a.教师招聘 确定教师招聘的优先顺序： 在我们的U54规划过程的早期，我们成立了一个特别工作组，开始制定我们将 包括在我们的跨学科健康差异研究重点中。跨学科问题特别工作组 2006年夏秋两季召开的健康差距研究包括： Timothy Ahles，MSKCC精神病学 玛丽·阿尔波，CCNY生物学 卡罗尔·布朗，MSKCC妇科肿瘤科 杰克·伯克哈尔特，MSKCC行为科学 凯伦·哈伯德，CCNY生物学 爱德华·凯勒，CCNY Media和 传播艺术 李月林，MSKCC精神病学和生物统计学 David Lounsbury，MSKCC行为科学 萨拉·奥尔森，MSKCC流行病学 卢卡斯·帕拉，CCNY生物医学工程 布鲁斯·拉普金，MSKCC行为科学 MSKCC胃肠病学博士Manish Shah 安·玛丽·亚利，CCNY心理学 Anne Zauber，MSKCC流行病学 该工作队产生了下文所述主题。其中每一个主题都被确定为 一家或两家机构的调查人员优先考虑。在某些情况下，我们没有教员合作伙伴 确定在两个机构的特定领域工作的人员。然而，通过定期研讨会和 在持续的规划过程中，我们会就以下每一个范畴的持续发展提出建议： 社区干预与传播研究 理由：我们计划招聘更多具有社区干预研究专业知识的教师。 调查人员可被安置在MSKCC精神病学和行为科学、医学、 流行病学，或其他与他们的专长相适应的领域。社区干预方面的额外教师 也是CCNY心理学、成人教育和社区卫生等部门的优先事项 和社会医学。下一步：我们将寻找有兴趣研究不同弱势群体的学者 改善护理标准，促进无障碍和鼓励健康的生活方式。 癌症治疗对神经认知的影响 理由：药物引起的大脑衰老可能会导致认知功能障碍。在他们的试行中 项目中，哈伯德博士、阿利斯博士和拉格诺特博士建议识别与 化疗后认知功能下降。教师招聘需求：^方面的其他专业知识 分子生物学、神经科学和老年肿瘤学将有助于推进这项工作。 生物标志物和遗传风险的参与性研究和识别 理论基础：随着生物医学研究寻求确定更多的癌症发病率或风险指标 发病率方面，有必要保持和跟踪代表不同人群的队列 明显的风险。参与性行动研究可能是吸引和留住队列的一种有前途的方式。 教师招聘需求：分子遗传学、群体遗传学/流行病学专家， 生物信息学/生物统计学家以及社区参与性研究人员。 增加癌症临床试验患者的多样性 理由：这一目标是MSKCC关注的中心领域。CCNY研究传播的学者， 决策、文化信仰、卫生经济学和医学伦理都可能有助于这一重点。 在这项申请中，Weiss博士和Binz-Sharf博士提议进行一项先导性研究，考察初级保健提供者的角色 在改善获得试验的机会方面。教师招聘需求：CCNY目前正在招聘学者 健康经济学和医学伦理学可以为这一研究做出贡献。 应激的生物心理社会学研究 理论基础：教职员工表示有兴趣研究慢性少数民族应激对细胞的影响 水平。研究将包括不同细胞机制的生物学以及 压力、应对和韧性。许多工作队成员找到了参与这一领域的方法，包括 流行病学家奥尔森和心理学家伯克哈尔特、罗萨里奥和雅利。教师招聘需求： 特别工作组讨论了在这一领域进行队列研究的必要性，包括分子生理学家， 流行病学家、心理学家、社会学家和神经内分泌学家。下一步将是 具体说明要考虑的目标人群，以及定义少数族裔压力的方法。 心理社会和行为干预的数学建模与仿真 理由：心理社会干预往往显示出个体在反应上的显著差异。 使用识别模式的算法来更准确地模拟干预结果是可能的 在数据方面。PCOP Lounsbury的Co-PI最近收到了一个NIDA RO3来进行系统动力学 初级保健中的戒烟模式。系统动力学是一种很有价值的仿真方法 用于评估卫生和公共服务政策。MSKCC的Li和Rapkin也对 这片区域。教师招聘需求：可能会为CCNY中心增加教师 高级计算算法。

Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: Timothy Ahles, MSKCC Psychiatry Mary Alpaugh, CCNY Biology Carol Brown, MSKCC Gynecological Oncology Jack Burkhalter, MSKCC Behavioral Sciences Karen Hubbard, CCNY Biology Edward Keller, CCNY Media and Communication Arts Yuelin Li, MSKCC Psychiatry and Biostatistics David Lounsbury, MSKCC Behavioral Sciences Sara Olson, MSKCC Epidemiology Lucas Parra, CCNY Biomedical Engineering Bruce Rapkin, MSKCC Behavioral Sciences Manish Shah, MSKCC Gastroenterology Ann Marie Yali, CCNY Psychology Anne Zauber, MSKCC Epidemiology This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Rationale: We plan to recruit additional faculty with expertise in community intervention research. Investigators may be housed in MSKCC Departments of Psychiatry and Behavioral Science, Medicine, Epidemiology, or other area appropriate to their expertise. Additional faculty in community intervention is also a priority at CCNY in departments including Psychology, Adult Education, and Community Health & Social Medicine. Next Steps: We will seek scholars interested in working with diverse underserved communities, to improve standards of care, promote access, and encourage healthy lifestyles. Neurocognitive Impacts of Cancer Therapeutics Rationale: Drug induced senescence in the brain may lead to cognitive dysfunction. In their pilot project, Drs. Hubbard, Alhes and Ragnauth propose to identify gene expression patterns correlated with cognitive decline following chemotherapy. Faculty Recruitment Needs: Additional expertise in ^ molecular biology, neuroscience and gerontological oncology would help to advance this work. Participatory Research and the Identification of Biomarkers and Genetic Risks Rationale: As biomedical research seeks to identify more indicators of risk for cancer incidence or morbidity, it is necessary to maintain and follow cohorts representing distinct populations at different apparent risk. Participatory action research may be a promising way to engage and retain cohorts. Faculty Recruitment Needs: Specialists in molecular genetics, population genetics/epidemiology, bioinformatics/biostatisticians as well as and community-based participatory researchers. Increasing the Diversity of Patients on Cancer Clinical Trials Rationale: This goal is a central area of concern at MSKCC. CCNY scholars who study communications, decision-making, cultural beliefs, health economics and medical ethics could all contribute to this focus. In this application, Drs. Weiss and Binz-Sharf propose a pilot study examine primary care providers' role in improving access to trials. Faculty Recruitment Needs: CCNY is presently recruiting scholars in health economics and medical ethics that could contribute to this line of research. Biopsychosocial Research on Stress Rationale: Faculty expressed interest in examining the impact of chronic minority stress at the cellular level. Research would encompass biology of different cellular mechanisms as well as psychology of stress, coping and resilience. Many Task Force members saw ways to get involved in this area, including epidemiologist Olson and psychologists Burkhalter, Rosario and Yali. Faculty Recruitment Needs: The Task Force discussed the need for cohort studies in this area, involving molecular physiologists, epidemiologists, psychologists, and sociologists, and neuroendocrinologists. Next steps would be to specify target populations to consider, as well as ways to define minority stress. Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions Rationale: Psychosocial interventions often demonstrate substantial individual differences in responses. It may be possible to model intervention outcomes more accurately using algorithms to identify patterns in data. Co-Pi of the PCOP Lounsbury recently received an NIDA RO3 to conduct system dynamics modeling of smoking cessation in primary care. Systems dynamics is a simulation methodology valuable for assessing health and human services policies. Li and Rapkin at MSKCC are also highly interested in this area. Faculty Recruitment Needs: There may be potential to add faculty to the CCNY Center for Advanced Computing Algorithms.