Developmental Core

发展核心

基本信息

批准号：
8327840
负责人：
KAREN HUBBARD
金额：
$ 143.54万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-02 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8327840
关键词：
Action Research Adult Advisory Committees Algorithms Area Arts Behavior Therapy Behavioral Sciences Belief Bioinformatics Biological Markers Biology Biomedical Engineering Biomedical Research Biometry Brain Cancer Center Caring Chronic Clinical Trials Cohort Studies Communication Communications Media Communities Community Health Education Community Outreach Computer Simulation Data Decision Making Development Education and Outreach Epidemiologist Epidemiology Faculty Gastroenterology Gene Expression Genetic Risk Goals Health Housing Human Impaired cognition Improve Access Incidence Individual Differences Institution Intervention Intervention Studies Lead Life Style Malignant Neoplasms Maps Medical Ethics Medicine Memorial Sloan-Kettering Cancer Center Methodology Minority Modeling Molecular Molecular Biology Molecular Genetics Morbidity - disease rate National Institute of Drug Abuse Neurocognitive Neurosciences Outcome Patients Pattern Pharmaceutical Preparations Pilot Projects Policies Population Population Genetics Primary Health Care Process Provider Psychiatry Psychologist Psychology Recommendation Recruitment Activity Research Research Personnel Risk Role Services Social Medicine Specialist Stress Stress and Coping System Target Populations Therapeutic To specify Work base biopsychosocial cancer risk chemotherapy cohort community intervention dissemination research falls genetic epidemiology health disparity health economics improved interest meetings member oncology psychosocial resilience response senescence simulation smoking cessation sociologist symposium

项目摘要

Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: Timothy Ahles, MSKCC Psychiatry Mary Alpaugh, CCNY Biology Carol Brown, MSKCC Gynecological Oncology Jack Burkhalter, MSKCC Behavioral Sciences Karen Hubbard, CCNY Biology Edward Keller, CCNY Media and Communication Arts Yuelin Li, MSKCC Psychiatry and Biostatistics David Lounsbury, MSKCC Behavioral Sciences Sara Olson, MSKCC Epidemiology Lucas Parra, CCNY Biomedical Engineering Bruce Rapkin, MSKCC Behavioral Sciences Manish Shah, MSKCC Gastroenterology Ann Marie Yali, CCNY Psychology Anne Zauber, MSKCC Epidemiology This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Rationale: We plan to recruit additional faculty with expertise in community intervention research. Investigators may be housed in MSKCC Departments of Psychiatry and Behavioral Science, Medicine, Epidemiology, or other area appropriate to their expertise. Additional faculty in community intervention is also a priority at CCNY in departments including Psychology, Adult Education, and Community Health & Social Medicine. Next Steps: We will seek scholars interested in working with diverse underserved communities, to improve standards of care, promote access, and encourage healthy lifestyles. Neurocognitive Impacts of Cancer Therapeutics Rationale: Drug induced senescence in the brain may lead to cognitive dysfunction. In their pilot project, Drs. Hubbard, Alhes and Ragnauth propose to identify gene expression patterns correlated with cognitive decline following chemotherapy. Faculty Recruitment Needs: Additional expertise in ^ molecular biology, neuroscience and gerontological oncology would help to advance this work. Participatory Research and the Identification of Biomarkers and Genetic Risks Rationale: As biomedical research seeks to identify more indicators of risk for cancer incidence or morbidity, it is necessary to maintain and follow cohorts representing distinct populations at different apparent risk. Participatory action research may be a promising way to engage and retain cohorts. Faculty Recruitment Needs: Specialists in molecular genetics, population genetics/epidemiology, bioinformatics/biostatisticians as well as and community-based participatory researchers. Increasing the Diversity of Patients on Cancer Clinical Trials Rationale: This goal is a central area of concern at MSKCC. CCNY scholars who study communications, decision-making, cultural beliefs, health economics and medical ethics could all contribute to this focus. In this application, Drs. Weiss and Binz-Sharf propose a pilot study examine primary care providers' role in improving access to trials. Faculty Recruitment Needs: CCNY is presently recruiting scholars in health economics and medical ethics that could contribute to this line of research. Biopsychosocial Research on Stress Rationale: Faculty expressed interest in examining the impact of chronic minority stress at the cellular level. Research would encompass biology of different cellular mechanisms as well as psychology of stress, coping and resilience. Many Task Force members saw ways to get involved in this area, including epidemiologist Olson and psychologists Burkhalter, Rosario and Yali. Faculty Recruitment Needs: The Task Force discussed the need for cohort studies in this area, involving molecular physiologists, epidemiologists, psychologists, and sociologists, and neuroendocrinologists. Next steps would be to specify target populations to consider, as well as ways to define minority stress. Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions Rationale: Psychosocial interventions often demonstrate substantial individual differences in responses. It may be possible to model intervention outcomes more accurately using algorithms to identify patterns in data. Co-Pi of the PCOP Lounsbury recently received an NIDA RO3 to conduct system dynamics modeling of smoking cessation in primary care. Systems dynamics is a simulation methodology valuable for assessing health and human services policies. Li and Rapkin at MSKCC are also highly interested in this area. Faculty Recruitment Needs: There may be potential to add faculty to the CCNY Center for Advanced Computing Algorithms.

发展核心以下各节描述了未来五年内我们的主要发展活动。 8.A.教师招聘确立教师招聘的优先事项：在U54计划过程的早期，我们组建了一个工作组，开始绘制我们将要的主题包括我们的跨学科健康差异研究重点。跨学科工作队 2006年夏季和秋季相遇的健康差异研究包括： Timothy Ahles，MSKCC精神病学玛丽·阿尔波（Mary Alpaugh），CCNY生物学 Carol Brown，MSKCC妇科肿瘤学杰克·伯克哈特（Jack Burkhalter），MSKCC行为科学 Karen Hubbard，CCNY生物学爱德华·凯勒（Edward Keller），CCNY媒体和传播艺术 Yuelin Li，MSKCC精神病学和生物统计学 David Lounsbury，MSKCC行为科学萨拉·奥尔森（Sara Olson），MSKCC流行病学卢卡斯·帕拉（Lucas Parra），CCNY生物医学工程 Bruce Rapkin，MSKCC行为科学 Manish Shah，MSKCC胃肠病学 Ann Marie Yali，CCNY心理学 Anne Zauber，MSKCC流行病学该工作队生成了下面描述的主题。这些主题中的每一个都被确定为一个或两个机构的调查人员优先考虑。在某些情况下，我们没有教师合作伙伴确定谁在两个机构的给定领域工作。但是，通过常规研讨会和持续的计划，我们将在每个领域中开发有关持续发展的建议：基于社区的干预和传播研究理由：我们计划在社区干预研究方面招募具有专业知识的其他教师。调查人员可以安置在MSKCC精神病学和行为科学部门，医学，流行病学或其他适合其专业知识的领域。社区干预的其他教师也是CCNY部门的优先事项，包括心理学，成人教育和社区健康和社会医学。下一步：我们将寻求有兴趣与服务不足的学者社区，以提高护理标准，促进访问并鼓励健康的生活方式。癌症治疗剂的神经认知影响理由：药物引起的大脑衰老可能导致认知功能障碍。在他们的飞行员中项目，博士。 Hubbard，Alhes和Ragnauth提出识别与化疗后认知下降。教师招聘需求： ^ 分子生物学，神经科学和老年学肿瘤学将有助于推进这项工作。参与性研究以及生物标志物和遗传风险的识别基本原理：随着生物医学研究试图确定更多癌症发生率或发病率，有必要维持和遵循代表不同种群在不同的人群明显的风险。参与性行动研究可能是参与和保留队列的一种有希望的方法。教师招聘需求：分子遗传学，种群遗传学/流行病学专家，生物信息学/生物统计学家以及社区的参与研究人员。增加患者在癌症临床试验中的多样性理由：这个目标是MSKCC关注的中心领域。研究沟通的CCNY学者，决策，文化信仰，卫生经济学和医学伦理都可以促进这一重点。在此应用程序中，博士。 Weiss和Binz-Sharf提出了一项试点研究检查初级保健提供者的角色在改善访问试验的过程中。教师招聘需求：CCNY目前正在招募学者健康经济学和医学伦理学，可能有助于这一研究。关于压力的生物心理社会研究理由：教师对检查慢性少数族裔在细胞上的影响表示兴趣等级。研究将涵盖不同细胞机制的生物学以及心理学压力，应对和韧性。许多工作队成员看到了参与这一领域的方法，包括流行病学家奥尔森（Olson）和心理学家伯克哈特（Burkhalter），罗萨里奥（Rosario）和雅利（Yali）。教师招聘需求：工作队讨论了该领域的队列研究的需求，涉及分子生理学家，流行病学家，心理学家和社会学家和神经内分泌学家。下一步将是指定目标人群以及定义少数族裔压力的方法。心理和行为干预的数学建模和模拟理由：社会心理干预措施通常表现出很大的反应中个体差异。可以使用算法更准确地对干预结果进行建模，以识别模式在数据中。 PCOP Lounsbury的Co-Pi最近收到了NIDA RO3来进行系统动力学在初级保健中戒烟的建模。系统动力学是一种仿真方法，有价值用于评估健康和公共服务政策。 MSKCC的Li和Rapkin也对这个区域。教师招聘需求：可能有可能增加教职员工的CCNY中心高级计算算法。