Developmental Core

发展核心

• 批准号: 8327840
• 负责人: KAREN HUBBARD
• 金额: $ 143.54万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-02 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8327840
• 关键词: Action Research; Adult; Advisory Committees; Algorithms; Area; Arts; Behavior Therapy; Behavioral Sciences; Belief; Bioinformatics; Biological Markers; Biology; Biomedical Engineering; Biomedical Research; Biometry; Brain; Cancer Center; Caring; Chronic; Clinical Trials; Cohort Studies; Communication; Communications Media; Communities; Community Health Education; Community Outreach; Computer Simulation; Data; Decision Making; Development; Education and Outreach; Epidemiologist; Epidemiology; Faculty; Gastroenterology; Gene Expression; Genetic Risk; Goals; Health; Housing; Human; Impaired cognition; Improve Access; Incidence; Individual Differences; Institution; Intervention; Intervention Studies; Lead; Life Style; Malignant Neoplasms; Maps; Medical Ethics; Medicine; Memorial Sloan-Kettering Cancer Center; Methodology; Minority; Modeling; Molecular; Molecular Biology; Molecular Genetics; Morbidity - disease rate; National Institute of Drug Abuse; Neurocognitive; Neurosciences; Outcome; Patients; Pattern; Pharmaceutical Preparations; Pilot Projects; Policies; Population; Population Genetics; Primary Health Care; Process; Provider; Psychiatry; Psychologist; Psychology; Recommendation; Recruitment Activity; Research; Research Personnel; Risk; Role; Services; Social Medicine; Specialist; Stress; Stress and Coping; System; Target Populations; Therapeutic; To specify; Work; base; biopsychosocial; cancer risk; chemotherapy; cohort; community intervention; dissemination research; falls; genetic epidemiology; health disparity; health economics; improved; interest; meetings; member; oncology; psychosocial; resilience; response; senescence; simulation; smoking cessation; sociologist; symposium

Developmental Core The following sections describe our major developmental activities over the next five years. 8.a. Faculty Recruitment Establishing Priorities for Faculty Recruitment: Early in our U54 Planning Process, we formed a Task Force to begin to map out topics that we would include in our Transdisciplinary Health Disparities Research Focus. The Task Force on Transdisciplinary Health Disparities Research that met in the summer and fall of 2006 included: Timothy Ahles, MSKCC Psychiatry Mary Alpaugh, CCNY Biology Carol Brown, MSKCC Gynecological Oncology Jack Burkhalter, MSKCC Behavioral Sciences Karen Hubbard, CCNY Biology Edward Keller, CCNY Media and Communication Arts Yuelin Li, MSKCC Psychiatry and Biostatistics David Lounsbury, MSKCC Behavioral Sciences Sara Olson, MSKCC Epidemiology Lucas Parra, CCNY Biomedical Engineering Bruce Rapkin, MSKCC Behavioral Sciences Manish Shah, MSKCC Gastroenterology Ann Marie Yali, CCNY Psychology Anne Zauber, MSKCC Epidemiology This Task Force generated themes described below. Each of these themes was identified as an area of priority by investigators at one or both institutions. In some instances, we do not have faculty partners identified who are working in a given area at both institutions. However, through regular symposia and on-going planning, we will develop recommendations for continuing development in each of these areas: Community-Based Intervention and Dissemination Research Rationale: We plan to recruit additional faculty with expertise in community intervention research. Investigators may be housed in MSKCC Departments of Psychiatry and Behavioral Science, Medicine, Epidemiology, or other area appropriate to their expertise. Additional faculty in community intervention is also a priority at CCNY in departments including Psychology, Adult Education, and Community Health & Social Medicine. Next Steps: We will seek scholars interested in working with diverse underserved communities, to improve standards of care, promote access, and encourage healthy lifestyles. Neurocognitive Impacts of Cancer Therapeutics Rationale: Drug induced senescence in the brain may lead to cognitive dysfunction. In their pilot project, Drs. Hubbard, Alhes and Ragnauth propose to identify gene expression patterns correlated with cognitive decline following chemotherapy. Faculty Recruitment Needs: Additional expertise in ^ molecular biology, neuroscience and gerontological oncology would help to advance this work. Participatory Research and the Identification of Biomarkers and Genetic Risks Rationale: As biomedical research seeks to identify more indicators of risk for cancer incidence or morbidity, it is necessary to maintain and follow cohorts representing distinct populations at different apparent risk. Participatory action research may be a promising way to engage and retain cohorts. Faculty Recruitment Needs: Specialists in molecular genetics, population genetics/epidemiology, bioinformatics/biostatisticians as well as and community-based participatory researchers. Increasing the Diversity of Patients on Cancer Clinical Trials Rationale: This goal is a central area of concern at MSKCC. CCNY scholars who study communications, decision-making, cultural beliefs, health economics and medical ethics could all contribute to this focus. In this application, Drs. Weiss and Binz-Sharf propose a pilot study examine primary care providers' role in improving access to trials. Faculty Recruitment Needs: CCNY is presently recruiting scholars in health economics and medical ethics that could contribute to this line of research. Biopsychosocial Research on Stress Rationale: Faculty expressed interest in examining the impact of chronic minority stress at the cellular level. Research would encompass biology of different cellular mechanisms as well as psychology of stress, coping and resilience. Many Task Force members saw ways to get involved in this area, including epidemiologist Olson and psychologists Burkhalter, Rosario and Yali. Faculty Recruitment Needs: The Task Force discussed the need for cohort studies in this area, involving molecular physiologists, epidemiologists, psychologists, and sociologists, and neuroendocrinologists. Next steps would be to specify target populations to consider, as well as ways to define minority stress. Mathematical Modeling and Simulation of Psychosocial and Behavioral Interventions Rationale: Psychosocial interventions often demonstrate substantial individual differences in responses. It may be possible to model intervention outcomes more accurately using algorithms to identify patterns in data. Co-Pi of the PCOP Lounsbury recently received an NIDA RO3 to conduct system dynamics modeling of smoking cessation in primary care. Systems dynamics is a simulation methodology valuable for assessing health and human services policies. Li and Rapkin at MSKCC are also highly interested in this area. Faculty Recruitment Needs: There may be potential to add faculty to the CCNY Center for Advanced Computing Algorithms.

开发核心 以下章节描述了我们未来五年的主要发展活动。 8.a.教师招聘 确定教师招聘的优先事项： 在U 54规划过程的早期，我们成立了一个工作组，开始制定我们将 包括在我们的跨学科健康差异研究重点。跨学科工作队 2006年夏季和秋季举行的健康差距研究包括： Timothy Ahles，MSKCC精神病学 玛丽阿尔堡，CCNY生物 Carol Brown，MSKCC妇科肿瘤 Jack Burkhalter，MSKCC行为科学 凯伦·哈伯德，CCNY生物学 爱德华·凯勒，CCNY媒体和 传播艺术 Yuelin Li，MSKCC精神病学和生物统计学 大卫朗斯伯里，MSKCC行为科学 Sara Olson，MSKCC流行病学 Lucas Parra，CCNY生物医学工程 布鲁斯拉普金，MSKCC行为科学 Manish Shah，MSKCC胃肠病学 Ann玛丽·雅莉，CCNY心理学 Anne Zauber，MSKCC流行病学 该工作组产生了下文所述的主题。每一个主题都被确定为一个领域， 由一个或两个机构的研究人员优先考虑。在某些情况下，我们没有教师合作伙伴 确定了在这两个机构的特定领域工作的人员。然而，通过定期的专题讨论会和 我们会继续进行规划工作，就以下各方面的持续发展提出建议： 基于社区的干预和传播研究 理由：我们计划招聘更多的教师与社区干预研究的专业知识。 研究者可能被安置在MSKCC精神病学和行为科学，医学， 流行病学或其他适合其专业知识的领域。社区干预的额外教师 也是CCNY的一个优先部门，包括心理学，成人教育和社区卫生 社会医学。下一步：我们将寻求有兴趣与各种服务不足的学者合作 社区，以提高护理标准，促进获得，并鼓励健康的生活方式。 癌症治疗对神经认知的影响 依据：药物诱导的大脑衰老可能导致认知功能障碍。在他们的飞行员 Hubbard，Alhes和Ragnauth博士提出，要确定与基因表达相关的基因表达模式， 化疗后认知能力下降教师招聘需求：更多的专业知识^ 分子生物学、神经科学和老年肿瘤学将有助于推动这项工作。 生物标志物和遗传风险的前瞻性研究和识别 理由：由于生物医学研究试图确定更多的癌症发病率风险指标， 为了提高发病率，有必要维持和跟踪代表不同人群的队列， 明显的风险。示范性行动研究可能是吸引和留住群体的一种有前途的方式。 教师招聘需求：分子遗传学，群体遗传学/流行病学， 生物信息学/生物统计学家以及社区参与式研究人员。 增加癌症临床试验患者的多样性 理由：这一目标是微软、科索沃合作委员会的一个核心关切领域。研究通信的CCNY学者， 决策、文化信仰、卫生经济学和医学道德都有助于这一重点。 在这项申请中，韦斯和宾兹-沙夫博士提出了一项试点研究，研究初级保健提供者的作用 在改善获得试验的机会方面。学院招聘需求：CCNY目前正在招聘学者， 健康经济学和医学伦理学，可以有助于这一研究。 压力的生物心理社会研究 理由：教师们表示有兴趣研究慢性少数民族压力对细胞的影响， 水平研究将包括不同细胞机制的生物学以及 压力、应对和复原力。许多工作队成员看到了参与这一领域的方法，包括 流行病学家奥尔森和心理学家伯克哈尔特、罗萨里奥和雅莉。教师招聘需求： 工作组讨论了在这一领域进行队列研究的必要性，包括分子生理学家， 流行病学家、心理学家、社会学家和神经内分泌学家。下一步将是 具体说明要考虑的目标人群，以及界定少数群体压力的方法。 心理社会和行为干预的数学建模与仿真 理由：心理社会干预往往表现出巨大的个体差异的反应。 使用算法来识别模式， 在数据中。PCOP Lounsbury的Co-Pi最近收到了NIDA RO 3来进行系统动力学研究 在初级保健中建立戒烟模型。系统动力学是一种很有价值的仿真方法学 用于评估卫生和公共服务政策。MSKCC的李和拉普金也对以下内容非常感兴趣 这方面教师招聘需求：有可能增加教师到CCNY中心， 高级计算算法