Genomics Proteomics Core

基因组学蛋白质组学核心

• 批准号: 8261440
• 负责人: RICHARD A SLAYDEN
• 金额: $ 19.68万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8261440
• 关键词: Arts; Binding; Bioinformatics; Communicable Diseases; Computer Assisted; Core Facility; Custom; Data Analyses; Detection; Development; Diagnostic; Drug Design; Equipment; Experimental Designs; Facility Accesses; Fee-for-Service Plans; Genomics; Goals; Human Resources; Laboratories; Learning; Molecular; Price; Proteomics; Public Health; Research; Research Personnel; Research Support; Resources; Role; Services; Technical Expertise; Technology; Therapeutic; Vaccine Adjuvant; Viral; base; biodefense; computing resources; cost; design; drug discovery; immunoregulation; instrumentation; man; mouse genome; pathogen; research study; tool

The goal of the Genomics Proteomics Core (Core E) of the Rocky Mountain Regional Center of Excellence in Biodefense (RMRCE) is to provide post-genomic resources and materials, to provide access to state-ofthe- art post-genomic instrumentation, and to provide expert assistance in performing post-genomic experiments, and bioinformatics, resulting in enhanced research opportunities for investigators at reduced costs. The GP-Core accomplishes this goal by producing whole genome mouse and pathogen DMA arrays and other molecular detection tools and platforms, by providing and maintaining post-genomic instrumentation in a centralized facility adjacent to the BL-3 laboratories, and by performing experimentation for investigators who would otherwise not be able to perform experiments because of a lack of manpower or expertise, and providing access to bioinformatics resources, staff, and support. The GP-Core also develops technology and custom platforms for investigators for focused or more advanced post-genomic studies. Accordingly, the GP-Core (1) produces and develops post-genomic resources for investigators, (2) provides access to post-genomic equipment (3) provides genomics, proteomics, and bioinformatics assistance and technical expertise, and (4) provides bioinformatics and Computer-Aided Drug Design (CADD) services to advance diagnostic and therapeutic drug discovery, design, and development for RMRCE investigators. Together, the activities of the GP-Core support research objectives on infectious diseases important to public health by providing resources and equipment that are required for post-genomic studies, technical assistance for experimental design, data analysis and other bioinformatics-related analyses, and postgenomic services on a fee-for-services basis. Core E will support all three of the RMRCE Integrated Research Foci on Immunomodulation, Adjuvants and Vaccines (IRF 1), Bacterial Therapeutics (IRF 2), and Viral Therapeutics (IRF 3). Its resources will be utilized by RPs 1.4, 1.6, 1.7, 2.1, 2.2, 2.3, 2.4, 2.5, 2.7 and 3.4

落基山地区卓越中心基因组学蛋白质组核心(核心E)的目标 在生物防务(RMRCE)是提供后基因组资源和材料，提供访问国家-最新的- ART后基因组仪器，并在进行后基因组测试方面提供专家协助 实验和生物信息学，为减少的研究人员增加了研究机会 成本。GP-Core通过生产全基因组小鼠和病原体DMA阵列来实现这一目标 以及其他分子检测工具和平台，通过提供和维护后基因组 在BL-3实验室附近的一个中央设施中进行仪器测试，并进行实验 对于因缺乏人力或其他原因而无法进行实验的研究人员 专业知识，并提供对生物信息学资源、工作人员和支持的访问。GP-Core还开发了 为研究人员提供集中或更高级的后基因组研究的技术和定制平台。 因此，GP-Core(1)为研究人员生产和开发后基因组资源，(2)提供 获得后基因组设备(3)提供基因组学、蛋白质组学和生物信息学援助 (4)提供生物信息学和计算机辅助药物设计(CADD)服务，以 为RMRCE研究人员提供先进的诊断和治疗药物发现、设计和开发。 总而言之，GP-Core的活动支持对公众重要的传染病研究目标 通过提供后基因组研究所需的资源和设备、技术 协助实验设计、数据分析和其他与生物信息学相关的分析，以及后基因组学 以服务收费为基础的服务。 核心E将支持RMRCE关于免疫调节、佐剂和 疫苗(IRF 1)、细菌治疗(IRF 2)和病毒治疗(IRF 3)。它的资源将是 由RPS 1.4、1.6、1.7、2.1、2.2、2.3、2.4、2.5、2.7和3.4使用