权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Multi-Scale Bio-Simulations

多尺度生物模拟

基本信息

批准号：
8325728
负责人：
Vittorio Cristini
金额：
$ 14.01万
依托单位：
METHODIST HOSPITAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8325728
关键词：
Accounting Adhesives Antineoplastic Agents Behavior Biomedical Engineering Blood Vessels Calibration Cardiology Cells Chairperson Chemical Engineering Collaborations Computer Simulation Development Discontinuous Capillary Doctor of Philosophy Endothelium Engineering Environment Epithelial Extravasation Generations Health Health Sciences Heating Information Sciences Injectable Internal Medicine Intracellular Transport Italy Lead Lesion Liver Mathematics Mechanics Medicine Modeling Nanotechnology Particulate Patients Physics Plasma Property Protocols documentation Research Simulate Solid Neoplasm System Techniques Texas Therapeutic Therapeutic Agents Tissues Universities Vascular Endothelium bioimaging biological systems biomathematics cell injury design improved macrophage mathematical model model design multi-scale modeling nanomedicine nanoscale nanosized professor response simulation small molecule tool transcytosis tumor tumor growth vascular endothelium permeability

项目摘要

Core 1 will provide an In silico framework (i) for modeling the systemic administration of therapeutic agents to solid tumors, their transport properties, and their efficacy in controlling tumor growth and (ii) for the 'rational design' of injectable nano-sized particulate systems (nPSs). The mathematical tools will be multi-scale and multi-physics spanning from the analysis of particulate transport within the vascular compartment (sovracellular level, > 10 um), to the adhesive interactions with the vascular walls and macrophages/Kuppfer cells within the liver sinusoids (cellular level, >1 um and <10 um); to the passive translocation across the vascular endothelium and Gl epithelial layers (sub-cellular level, < 1 um), down to the cellular internalization and intracellular transport (sub-cellular level, ¿ 1 um). This core is composed by modules, highly integrated one with the other the other core. Core 1 is co-lead by Drs. Cristini and Decuzzi with the collaboration of Dr. Ferrari and Dr. Macklin. Dr. Cristini (Ph.D. Chemical Engineering, FAAN) is an Associate Professor of Biomedical Engineering and Health Information Sciences at the University of Texas Health Science Center and provides multiscale modeling expertise. Dr. Decuzzi (Ph.D. Mechanical Engineering) is an Associate Professor of Mechanical and Biomedical Engineering at the University of Texas Health Science Center and the Center for Bio/Nanotechnology and Engineering for Medicine at the University of Magna Graecia (In Italy). Dr. Ferrari (Ph.D. Mechanical Engineering) is professor of Professor and Director of the Division of Nanomedicine and Professor of Internal Medicine in the Cardiology Division of The University of Texas Health Science Center, Deputy Chairman of the Department of Biomedical Engineering at the University of Texas. Dr. Macl<lin (Ph.D. Applied Mathematics) is an Assistant Professor of Health Information Sciences at the University of Texas Health Science Center and has researched mathematical modeling of tunnors and their local environment [120-123] and provides expertise in applied mathematics.

核心1将提供一个硅框架(i)用于模拟治疗药物对实体肿瘤的系统给药，它们的运输特性，以及它们在控制肿瘤生长方面的功效；（ii）用于可注射纳米颗粒系统（nps）的“合理设计”。数学工具将是多尺度和多物理跨越分析颗粒运输在血管室（索细胞）