Multi-Scale Bio-Simulations

多尺度生物模拟

基本信息

批准号：
8564200
负责人：
Vittorio Cristini
金额：
$ 35.01万
依托单位：
METHODIST HOSPITAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-28 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8564200
关键词：
Accounting Adhesives Antineoplastic Agents Behavior Biomedical Engineering Blood Vessels Calibration Cardiology Cells Chairperson Chemical Engineering Collaborations Computer Simulation Development Discontinuous Capillary Doctor of Philosophy Endothelium Engineering Environment Epithelial Extravasation Generations Health Health Sciences Heating Information Sciences Injectable Internal Medicine Intracellular Transport Italy Lead Lesion Liver Mathematics Mechanics Medicine Modeling Nanotechnology Particulate Patients Physics Plasma Property Protocols documentation Research Simulate Solid Neoplasm System Techniques Texas Therapeutic Therapeutic Agents Tissues Universities Vascular Endothelium bioimaging biological systems biomathematics cell injury design improved macrophage mathematical model model design multi-scale modeling nanomedicine nanoscale nanosized professor response simulation small molecule tool transcytosis tumor tumor growth tumor microenvironment vascular endothelium permeability

项目摘要

Core 1 will provide an In silico framework (i) for modeling the systemic administration of therapeutic agents to solid tumors, their transport properties, and their efficacy in controlling tumor growth and (ii) for the 'rational design' of injectable nano-sized particulate systems (nPSs). The mathematical tools will be multi-scale and multi-physics spanning from the analysis of particulate transport within the vascular compartment (sovracellular level, > 10 um), to the adhesive interactions with the vascular walls and macrophages/Kuppfer cells within the liver sinusoids (cellular level, >1 um and <10 um); to the passive translocation across the vascular endothelium and Gl epithelial layers (sub-cellular level, < 1 um), down to the cellular internalization and intracellular transport (sub-cellular level, ¿ 1 um). This core is composed by modules, highly integrated one with the other the other core. Core 1 is co-lead by Drs. Cristini and Decuzzi with the collaboration of Dr. Ferrari and Dr. Macklin. Dr. Cristini (Ph.D. Chemical Engineering, FAAN) is an Associate Professor of Biomedical Engineering and Health Information Sciences at the University of Texas Health Science Center and provides multiscale modeling expertise. Dr. Decuzzi (Ph.D. Mechanical Engineering) is an Associate Professor of Mechanical and Biomedical Engineering at the University of Texas Health Science Center and the Center for Bio/Nanotechnology and Engineering for Medicine at the University of Magna Graecia (In Italy). Dr. Ferrari (Ph.D. Mechanical Engineering) is professor of Professor and Director of the Division of Nanomedicine and Professor of Internal Medicine in the Cardiology Division of The University of Texas Health Science Center, Deputy Chairman of the Department of Biomedical Engineering at the University of Texas. Dr. Macl<lin (Ph.D. Applied Mathematics) is an Assistant Professor of Health Information Sciences at the University of Texas Health Science Center and has researched mathematical modeling of tunnors and their local environment [120-123] and provides expertise in applied mathematics.

CORE 1将提供一个在计算机框架中（i），用于建模对实体瘤的治疗剂，其运输特性以及它们在控制肿瘤生长方面的效率以及（ii）的效率以及（ii）的“理性设计”。数学工具将是多尺度和多物理学，跨越了对血管隔室内特定传输的分析（Sovracellular 水平> 10 um），与肝正正弦体内的血管壁和巨噬细胞/kuppfer细胞的粘合剂相互作用（细胞水平，> 1 UM和<10 UM）；到跨血管内皮和GL上皮层（细胞下水平，<1 um）的被动易位，直至细胞内部化和细胞内转运（亚细胞水平，€1 UM）。该核心由模块组成，高度集成一个与另一个核心。核心1是Drs共同领导的。克里斯蒂尼（Cristini）和decuzzi与法拉利（Ferrari）博士和麦克林（Macklin）博士的合作。克里斯蒂尼（Cristini）博士（FAAN化学工程博士学位）是德克萨斯大学健康科学中心生物医学工程和健康信息科学副教授，并提供了多尺度建模专业知识。 Decuzzi博士（博士机械工程博士）是一名助理德克萨斯大学健康科学中心的机械与生物医学工程教授，麦格纳·格雷西亚大学（意大利）的生物/纳米技术与工程中心（在意大利）。 Ferrari博士（机械工程博士学位）是德克萨斯大学健康科学中心心脏病学系教授兼纳米医学系教授兼内科教授，生物医学工程系副主席德克萨斯州。 MACL <lin博士（应用数学博士学位）是德克萨斯大学健康科学中心健康信息科学助理教授，并研究了隧道及其当地环境的数学建模[120-123]，并提供了应用数学的专业知识。