Multi-Scale Bio-Simulations

多尺度生物模拟

• 批准号: 8564200
• 负责人: Vittorio Cristini
• 金额: $ 35.01万
• 依托单位: METHODIST HOSPITAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8564200
• 关键词: Accounting; Adhesives; Antineoplastic Agents; Behavior; Biomedical Engineering; Blood Vessels; Calibration; Cardiology; Cells; Chairperson; Chemical Engineering; Collaborations; Computer Simulation; Development; Discontinuous Capillary; Doctor of Philosophy; Endothelium; Engineering; Environment; Epithelial; Extravasation; Generations; Health; Health Sciences; Heating; Information Sciences; Injectable; Internal Medicine; Intracellular Transport; Italy; Lead; Lesion; Liver; Mathematics; Mechanics; Medicine; Modeling; Nanotechnology; Particulate; Patients; Physics; Plasma; Property; Protocols documentation; Research; Simulate; Solid Neoplasm; System; Techniques; Texas; Therapeutic; Therapeutic Agents; Tissues; Universities; Vascular Endothelium; bioimaging; biological systems; biomathematics; cell injury; design; improved; macrophage; mathematical model; model design; multi-scale modeling; nanomedicine; nanoscale; nanosized; professor; response; simulation; small molecule; tool; transcytosis; tumor; tumor growth; tumor microenvironment; vascular endothelium permeability

Core 1 will provide an In silico framework (i) for modeling the systemic administration of therapeutic agents to solid tumors, their transport properties, and their efficacy in controlling tumor growth and (ii) for the 'rational design' of injectable nano-sized particulate systems (nPSs). The mathematical tools will be multi-scale and multi-physics spanning from the analysis of particulate transport within the vascular compartment (sovracellular level, > 10 um), to the adhesive interactions with the vascular walls and macrophages/Kuppfer cells within the liver sinusoids (cellular level, >1 um and <10 um); to the passive translocation across the vascular endothelium and Gl epithelial layers (sub-cellular level, < 1 um), down to the cellular internalization and intracellular transport (sub-cellular level, ¿ 1 um). This core is composed by modules, highly integrated one with the other the other core. Core 1 is co-lead by Drs. Cristini and Decuzzi with the collaboration of Dr. Ferrari and Dr. Macklin. Dr. Cristini (Ph.D. Chemical Engineering, FAAN) is an Associate Professor of Biomedical Engineering and Health Information Sciences at the University of Texas Health Science Center and provides multiscale modeling expertise. Dr. Decuzzi (Ph.D. Mechanical Engineering) is an Associate Professor of Mechanical and Biomedical Engineering at the University of Texas Health Science Center and the Center for Bio/Nanotechnology and Engineering for Medicine at the University of Magna Graecia (In Italy). Dr. Ferrari (Ph.D. Mechanical Engineering) is professor of Professor and Director of the Division of Nanomedicine and Professor of Internal Medicine in the Cardiology Division of The University of Texas Health Science Center, Deputy Chairman of the Department of Biomedical Engineering at the University of Texas. Dr. Macl<lin (Ph.D. Applied Mathematics) is an Assistant Professor of Health Information Sciences at the University of Texas Health Science Center and has researched mathematical modeling of tunnors and their local environment [120-123] and provides expertise in applied mathematics.

核心1将提供一个计算机模拟框架（i）用于模拟治疗剂对实体瘤的全身给药、其转运特性及其控制肿瘤生长的功效，以及（ii）用于可注射纳米尺寸颗粒系统（nPS）的“合理设计”。数学工具将是多尺度和多物理学的，从血管隔室（sovracellular）内的颗粒运输的分析跨越 水平，> 10 um），与肝窦内血管壁和巨噬细胞/Kuppfer细胞的粘附相互作用（细胞水平，>1 um和<10 um）;穿过血管内皮和GI上皮层的被动易位（亚细胞水平，< 1 um），下至细胞内化和细胞内转运（亚细胞水平，<$1 um）。该核心由模块组成，高度集成 另一个是另一个核心核心1由Cristini博士和Decuzzi博士共同领导，并与Ferrari博士和Macklin博士合作。Dr. Cristini（Ph.D.化学工程，FAAN）是德克萨斯大学健康科学中心生物医学工程和健康信息科学的副教授，提供多尺度建模专业知识。Decuzzi博士（博士）机械工程）是一个准 德克萨斯大学健康科学中心机械和生物医学工程教授，麦格纳格拉古大学生物/纳米技术和医学工程中心（意大利）。Ferrari博士（Ph.D.机械工程）是教授和纳米医学部主任和内科教授在心脏病学部的得克萨斯大学健康科学中心，副主席的生物医学工程系在得克萨斯大学 德克萨斯Dr. Macl<lin（Ph.D.应用数学）是德克萨斯大学健康科学中心的健康信息科学助理教授，研究隧道及其当地环境的数学建模[120-123]，并提供应用数学方面的专业知识。