Multi-Scale Bio-Simulations

CORE 1将提供一个电子框架(I)用于模拟治疗药物对实体肿瘤的系统给药、它们的传输特性以及它们在控制肿瘤生长方面的有效性，以及(Ii)可注射纳米颗粒系统(NPSS)的“合理设计”。数学工具将是多尺度和多物理的，从分析血管隔间内的颗粒传输(胞浆) 从与肝窦内的血管壁和巨噬细胞/Kuppfer细胞的粘附性相互作用(细胞水平，&gt；1um和&lt；10um)，到跨血管内皮细胞和Gl上皮层的被动移位(亚细胞水平，&lt；1um)，向下到细胞内化和细胞内运输(亚细胞水平，±1um)。该核心由模块组成，高度集成 另一个是另一个核心。CORE 1由克里斯蒂尼博士和德库齐博士共同领导，法拉利博士和麦克林博士合作。克里斯蒂尼博士(化学工程博士，FAAN)是德克萨斯大学健康科学中心的生物医学工程和健康信息科学副教授，提供多尺度建模专业知识。德库齐博士(机械工程学博士)是 德克萨斯大学健康科学中心和意大利麦格纳大学生物/纳米技术和医学工程中心机械和生物医学工程教授。Ferrari博士(机械工程博士)是德克萨斯大学健康科学中心心脏科教授、纳米医学部主任、内科教授，德克萨斯大学生物医学工程系副主任 德克萨斯州。Macl&lt；Lin博士(应用数学博士)是德克萨斯大学健康科学中心的健康信息科学助理教授，研究过隧道及其当地环境的数学模型[120-123]，并提供应用数学方面的专业知识。

Core 1 will provide an In silico framework (i) for modeling the systemic administration of therapeutic agents to solid tumors, their transport properties, and their efficacy in controlling tumor growth and (ii) for the 'rational design' of injectable nano-sized particulate systems (nPSs). The mathematical tools will be multi-scale and multi-physics spanning from the analysis of particulate transport within the vascular compartment (sovracellular level, > 10 um), to the adhesive interactions with the vascular walls and macrophages/Kuppfer cells within the liver sinusoids (cellular level, >1 um and <10 um); to the passive translocation across the vascular endothelium and Gl epithelial layers (sub-cellular level, < 1 um), down to the cellular internalization and intracellular transport (sub-cellular level, ¿ 1 um). This core is composed by modules, highly integrated one with the other the other core. Core 1 is co-lead by Drs. Cristini and Decuzzi with the collaboration of Dr. Ferrari and Dr. Macklin. Dr. Cristini (Ph.D. Chemical Engineering, FAAN) is an Associate Professor of Biomedical Engineering and Health Information Sciences at the University of Texas Health Science Center and provides multiscale modeling expertise. Dr. Decuzzi (Ph.D. Mechanical Engineering) is an Associate Professor of Mechanical and Biomedical Engineering at the University of Texas Health Science Center and the Center for Bio/Nanotechnology and Engineering for Medicine at the University of Magna Graecia (In Italy). Dr. Ferrari (Ph.D. Mechanical Engineering) is professor of Professor and Director of the Division of Nanomedicine and Professor of Internal Medicine in the Cardiology Division of The University of Texas Health Science Center, Deputy Chairman of the Department of Biomedical Engineering at the University of Texas. Dr. Macl<lin (Ph.D. Applied Mathematics) is an Assistant Professor of Health Information Sciences at the University of Texas Health Science Center and has researched mathematical modeling of tunnors and their local environment [120-123] and provides expertise in applied mathematics.