多巴哥尼亚人前列腺癌的分子流行病学-猫眼课题宝

多巴哥尼亚人前列腺癌的分子流行病学

批准号：

7926191

负责人：

CLAREANN H. BUNKER

金额：

$21.06万

依托单位：

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-09-30 至 2011-09-29

来源：

https://reporter.nih.gov/project-details/7926191

关键词：

Address African African American Age Androgens Antigens Archives Arts Biological Bone Density Cancer Etiology Cancer-Predisposing Gene Caribbean region Caucasians Caucasoid Race Chronic Collaborations DNA Data Data Set Databases Development Disease ESR1 gene ESR2 gene Employee Strikes Environmental Risk Factor Estrogen Receptors Estrogens Etiology Exposure to Funding Future Genes Genetic Polymorphism Genetic Predisposition to Disease Genotype Gonadal Steroid Hormones Growth Factor Haplotypes Herpesviridae Hormonal Hormones Human Human Herpes Virus 8 Infection IL6 gene Incidence Infection Interleukin-2 Interleukin-6 International Intervention Island Lead Libraries Link Malignant neoplasm of prostate Measurement Mining Modeling Molecular Molecular Biology Molecular Epidemiology of Prostate Cancer NCOA3 gene Nuclear Participant Play Population Population Group Predisposition Prevalence Prevention strategy Prospective Studies Prostate Public Health Research Infrastructure Response Elements Risk Risk Factors Role Sampling Screening procedure Series Serologic tests Serum Signal Transduction Specimen Structure of base of prostate Surveys Susceptibility Gene Testing Tissues Tobago Transcription Coactivator Unsafe Sex Urine Vaccines Variant Viral Virus Work aged base biobank cancer risk case control caucasian American cohort fascinate follow-up high risk high risk men human IL6ST protein insight interest men novel population based prospective therapy development

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Higher prostate cancer risk is well established in African Americans compared with Caucasian Americans, but little is known about factors contributing to this high risk. In our Tobago Prostate Survey, we have documented an extraordinarily high rate of prostate cancer, 16% among Tobago men aged 50-79, in the Afro-Caribbean population on the island of Tobago. We have discovered three risk domains which may contribute to the excess prostate cancer risk in this population: 1) indicators of high cumulative exposure to mitogenic factors (e.g., sex steroid hormones, growth factors) as assessed by bone mineral density; 2) host susceptibility (molecular variation in genes related to sex steroid hormone and interleukin 6 signaling); and 3) infection (most likely chronic) with human herpes virus 8 (HHV8). Moreover, our studies suggest biologically plausible interactions among these risk domains. Specific aims. 1. Continue screening to increase the case control series to 550 cases, 1100 non-cases. 2. To evaluate the association of molecular variation in major hormonal signaling genes and susceptibility to prostate cancer among Afro-Caribbean men. 3. To test the hypotheses that HHV8 exposure and molecular variation in the hormonal signaling genes are each independently related to prostate cancer risk, and test the hypothesis that interactions among these factors are a major determinant of risk. Data from other studies suggest that African Americans share the high risk sex hormone related genotypes observed in the Tobago population. HHV8 seropositivity is not rare in the US population. Confirmation of the association of HHV8 infection with prostate cancer risk, and further definition of sex hormone related genetic susceptibility, will identify a high risk group which may warrant development of interventions, such as hormone modulation, or HHV8 vaccine or anti-viral therapy, which could reduce risk for prostate cancer among Afro-Caribbeans, African Americans and other populations.

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