Duke Comp Cancer Inst. Core Support Grant

杜克大学癌症研究所

• 批准号: 8322901
• 负责人: ANTHONY MEANS
• 金额: $ 7.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8322901
• 关键词: American Cancer Society; Basic Science; Biomedical Research; Cancer Biology; Cancer Patient; Charge; Clinical Oncology; Collaborations; Data; Department of Defense; Development; Developmental Biology; Enrollment; Funding; Future; Genomics; Goals; Grant; Institutes; Interdisciplinary Study; Journals; Laboratories; Malignant Neoplasms; National Cancer Institute; Paper; Patients; Peer Review; Pilot Projects; PubMed; Publications; Publishing; Request for Applications; Research; Research Institute; Resource Sharing; Resources; Scientific Advances and Accomplishments; Signal Pathway; Societies; Source; Testing; Therapeutic Clinical Trial; anticancer research; cancer risk; chemotherapy; improved; innovation; insight; member; oncology; operation; programs; statistical center

The recently reorganized Duke Comprehensive Cancer Institute (DCCI) is charged to serve as the center of all Duke activities in cancer, with an imperative to oversee all of the Duke cancer operations in the future. As a matrix center in one of the largest biomedical research institutes, the DCCI has been continuously supported by the National Cancer Institute (NCI) for over 36 years, by leveraging Duke's basic research strengths with significant clinical oncology research excellence which is enabled by treating 5,581 new cancer patients annually, enrolling over 1,000 patients annually onto therapeutic clinical trials, and enhanced by the presence of national oncology research resources, such as the data and statistical centers of two NCI-funded cooperative groups. Total membership in the DCCI is 285 members, with members having an increasingly prominent focus in cancer research and increased amount of NCI funding since 2004. Total funding for program members is $331,617,013, of which $269,525,804 is from peer-reviewed sources. A cancer focus is illustrated by $77,785,582 or 23.5% of funding from the NCI, the American Cancer Society or the Department of Defense. From 2004-2008, program members published 6,941 papers in peer-reviewed journals cited in PubMed. Of these publications, 10% are the result of intra-programmatic collaborations and 19% due to inter-programmatic collaborations. In this competitive renewal application, we request support our membership in 11 Research Programs supported by 17 Shared Resources. DCCI members made significant scientific advances including: the development of innovative genomic tests to predict which cancer patients would respond to specific chemotherapy, and basic insight into critical signaling pathways in cancer and developmental biology. The DCCI oversees all cancer related philanthropy at Duke, and these funds have been used to support recruitment of new members, innovative pilot projects, support of multidisciplinary research, and new laboratory and administrative space. This application for ongoing support of the DCC articulates the principles, goals and strategies for propelling the DCCI to fully leverage the enormous advances in biomedical research at Duke and beyond, to improve and extend the lives of cancer patients with cancer and at risk for cancer, and delivering these to society.

最近重组的杜克综合癌症研究所 (DCCI) 负责作为癌症研究中心 杜克大学在癌症领域的所有活动，未来有必要监督杜克大学的所有癌症手术。作为 作为最大的生物医学研究机构之一的矩阵中心，DCCI 一直在不断地 通过利用杜克大学的基础研究，获得美国国家癌症研究所 (NCI) 超过 36 年的支持 凭借卓越的临床肿瘤学研究优势，通过治疗 5,581 名新患者而得以实现 每年招募 1,000 多名癌症患者参加治疗性临床试验，并增强 国家肿瘤学研究资源的存在，例如两个国家的数据和统计中心 NCI 资助的合作团体。 DCCI 共有 285 名会员，其中会员拥有 自 2004 年以来，癌症研究的关注日益突出，NCI 资助金额不断增加。 总计 为方案成员提供的资金为 331,617,013 美元，其中 269,525,804 美元来自同行评审来源。一个 癌症重点由 NCI、美国癌症协会或美国癌症协会资助的 77,785,582 美元或 23.5% 来说明 国防部。从 2004 年到 2008 年，项目成员在同行评审中发表了 6,941 篇论文 PubMed 引用的期刊。在这些出版物中，10% 是项目内合作的结果 19% 由于项目间合作。在此竞争性续订申请中，我们请求支持 我们是 11 个研究项目的会员，并得到 17 个共享资源的支持。 DCCI会员制作 重大科学进步包括： 开发创新的基因组测试来预测哪种癌症 患者会对特定化疗产生反应，并对癌症关键信号通路有基本了解 和发育生物学。 DCCI 负责监督杜克大学所有与癌症相关的慈善事业，这些基金 已用于支持新成员的招募、创新试点项目、支持多学科 研究、新的实验室和行政空间。此应用程序持续支持 DCC 阐明了推动 DCCI 充分利用 杜克大学及其他大学在生物医学研究方面取得的巨大进步，以改善和延长癌症的寿命 癌症患者和有患癌症风险的患者，并将其传递给社会。