Comprehensive Sickle Cell Center Composite:Basic & Translational Research Program

描述(由申请人提供)： 根据RFA-HL-06-008号文件，圣裘德综合镰刀细胞中心自豪地提出了其竞争性续签拨款申请，题为“综合镰刀细胞中心”。在过去的5年里，圣裘德儿童研究医院(SJCRH)建立了一流的综合镰状细胞中心，该中心开展尖端的基础和临床研究，提供最先进的临床护理和患者服务，并提供与镰状细胞病(SCD)相关的卓越教育和培训。作为NHLBI CSCC网络的一员，圣裘德经常是由综合镰刀细胞中心组成的，在批准的中心间网络项目中，圣裘德以出色的登记、参与和领导而脱颖而出。在即将到来的5年资助周期中，圣裘德将继续保持这一卓越的良好记录，但将扩大努力，将SCD翻译和患者服务成果研究包括在内，并将通过与田纳西大学(UT)在Diggs-Kraus镰刀细胞中心和UT癌症研究所新建立的合作，为SCD成人提供强有力的医疗护理和研究承诺。圣裘德综合镰刀细胞中心仍然致力于促进对疾病病理生理学的了解，改进医疗管理模式，并开发SCD的治疗方法。

DESCRIPTION (provided by applicant): The St. Jude Comprehensive Sickle Cell Center proudly presents its competitive renewal grant application in response to RFA-HL-06-008 entitled, "Comprehensive Sickle Cell Centers". Over the past 5 years, St. Jude Children's Research Hospital (SJCRH) has established a premier Comprehensive Sickle Cell Center that conducts cutting-edge basic and clinical research, provides state-of-the art clinical care and patient services, and offers outstanding education and training related to sickle cell disease (SCD). As a member of the NHLBI CSCC network comprised often Comprehensive Sickle Cell Centers, St. Jude has distinguished itself with outstanding enrollment, participation, and leadership for approved inter-Center network projects. For the upcoming 5-year funding cycle, St. Jude will continue this strong track record of excellence, but will expand efforts to include SCD translational and patient services outcomes research, and also will offer a robust commitment to medical care and research for adults with SCD through newly established collaborations with the University of Tennessee (UT) at both the Diggs-Kraus Sickle Cell Center and the UT Cancer Institute. The St. Jude Comprehensive Sickle Cell Center remains committed to advancing understanding of disease pathophysiology, to improving medical management modalities, and to developing cures for SCD.