Comprehensive Sickle Cell Center Composite:Basic & Translational Research Program

综合镰状细胞中心复合物：基本

• 批准号: 7821232
• 负责人: DEREK A PERSONS
• 金额: $ 75.29万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7821232
• 关键词: Comprehensive; Sickle; Cell; Center; Composite

DESCRIPTION (provided by applicant): The St. Jude Comprehensive Sickle Cell Center proudly presents its competitive renewal grant application in response to RFA-HL-06-008 entitled, "Comprehensive Sickle Cell Centers". Over the past 5 years, St. Jude Children's Research Hospital (SJCRH) has established a premier Comprehensive Sickle Cell Center that conducts cutting-edge basic and clinical research, provides state-of-the art clinical care and patient services, and offers outstanding education and training related to sickle cell disease (SCD). As a member of the NHLBI CSCC network comprised often Comprehensive Sickle Cell Centers, St. Jude has distinguished itself with outstanding enrollment, participation, and leadership for approved inter-Center network projects. For the upcoming 5-year funding cycle, St. Jude will continue this strong track record of excellence, but will expand efforts to include SCD translational and patient services outcomes research, and also will offer a robust commitment to medical care and research for adults with SCD through newly established collaborations with the University of Tennessee (UT) at both the Diggs-Kraus Sickle Cell Center and the UT Cancer Institute. The St. Jude Comprehensive Sickle Cell Center remains committed to advancing understanding of disease pathophysiology, to improving medical management modalities, and to developing cures for SCD.

描述（由申请人提供）： 圣裘德综合镰状细胞中心自豪地提出其竞争性更新赠款申请，以回应RFA-HL-06-008题为“综合镰状细胞中心”。在过去的5年里，圣裘德儿童研究医院（SJCRH）建立了一个首屈一指的综合性镰状细胞中心，进行尖端的基础和临床研究，提供最先进的临床护理和患者服务，并提供与镰状细胞病（SCD）相关的优秀教育和培训。作为NHLBI CSCC网络的成员，通常包括综合性镰状细胞中心，圣裘德以出色的招生，参与和领导批准的中心间网络项目而闻名。在即将到来的5年资助周期中，圣裘德将继续保持这一卓越的良好记录，但将扩大努力，包括SCD转化和患者服务结果研究，并将通过与田纳西大学（UT）在Diggs-Kraus镰状细胞中心和UT癌症研究所新建立的合作，为SCD成人提供强有力的医疗保健和研究承诺。圣裘德综合镰状细胞中心仍然致力于推进疾病病理生理学的理解，以改善医疗管理模式，并开发治疗SCD。

项目成果

Improved renal perfusion measurement with a dual navigator-gated Q2TIPS fair technique.

使用双导航器门控 Q2TIPS fair 技术改进了肾灌注测量。

• DOI: 10.1002/mrm.22532
• 发表时间: 2010
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Song,Ruitian;Loeffler,RalfB;Hillenbrand,ClaudiaM
• 通讯作者: Hillenbrand,ClaudiaM

QUIPSS II with window-sliding saturation sequence (Q2WISE).

具有窗口滑动饱和序列 (Q2WISE) 的 QUIPSS II。

• DOI: 10.1002/mrm.23093
• 发表时间: 2012
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Song,Ruitian;Loeffler,RalfB;Hillenbrand,ClaudiaM
• 通讯作者: Hillenbrand,ClaudiaM

Pharmacotherapy in sickle cell disease--state of the art and future prospects.

• DOI: 10.1111/j.1365-2141.2009.07602.x
• 发表时间: 2009-05
• 期刊: British journal of haematology
• 影响因子: 6.5
• 作者: Hankins J;Aygun B
• 通讯作者: Aygun B

Hemodynamic responses to visual stimulation in children with sickle cell anemia.

镰状细胞性贫血儿童对视觉刺激的血流动力学反应。

• DOI: 10.1007/s11682-011-9133-4
• 发表时间: 2011
• 期刊: Brain imaging and behavior
• 影响因子: 3.2
• 作者: Zou,Ping;Helton,KathleenJ;Smeltzer,Matthew;Li,Chin-Shang;Conklin,HeatherM;Gajjar,Amar;Wang,WinfredC;Ware,RussellE;Ogg,RobertJ
• 通讯作者: Ogg,RobertJ

The painful face of poverty.

• DOI: 10.1002/pbc.21856
• 发表时间: 2009-02
• 期刊: Pediatric blood & cancer
• 影响因子: 3.2
• 作者: Hankins J;Wang W
• 通讯作者: Wang W