COBRE Center for Evolutionary and Theoretical Immunology

COBRE 进化和理论免疫学中心

• 批准号: 8268361
• 负责人: ERIC SAMUEL LOKER
• 金额: $ 217.37万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268361
• 关键词: Animals; Awareness; Benchmarking; Biology; Biomedical Research; Biophysics; Centers of Research Excellence; Collaborations; Communities; Comparative Study; Controlled Environment; Core Facility; Development; Disease susceptibility; Effectiveness; Ensure; Epidemic; Equipment; Evolution; Faculty; Funding; Funding Opportunities; Goals; Grant; Home environment; Human; Human Resources; Immune; Immune response; Immune system; Immunology; Invertebrates; Journals; Laboratories; Lead; Logistics; Mass Spectrum Analysis; Medicine; Mentors; Mission; Modeling; Molecular Biology; National Center for Research Resources; New Mexico; Parasitic Diseases; Participant; Phase; Preparation; Production; Program Development; Proteomics; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientific Advances and Accomplishments; Seeds; Structure; Theoretical Biology; Time; Training; United States National Institutes of Health; Universities; Vector-transmitted infectious disease; Virus Diseases; Work; base; career; career development; catalyst; computer science; cost; design; flexibility; improved; innovation; interest; member; novel; novel therapeutics; pathogen; programs; success; transmission process

Building on the critical mass of expertise and infrastructure assembled during our first funding period, this proposal seeks five more years of support through NCRR's COBRE program to enable us to further strengthen and consolidate a self-sustaining and flourishing Center for Evolutionary and Theoretical Immunology (CETI). Once again, both junior and senior faculty scholars from the Biology and Computer Science Departments at the University of New Mexico and the Los Alamos National Labs will undertake research projects that seek to reveal basic design principles of immune systems, that model the interactions between pathogens and immune systems, and that explore the evolution of immune responses across animal phyla. Consequently, we will better understand how invertebrate vectors transmit infectious diseases, how pathogens defend themselves from immune attack and how the comparative study of immune systems can lead to exciting new conceptual frameworks and paradigms. We will also improve our mentoring program to develop independently-funded junior investigators, provide our members logistical support in grant preparation and management and at every opportunity strive to improve their long-term career prospects. We will hire additional CETI-related tenure track faculty and continue to partner with other NCRR-programs and the UNM administration to support and improve CETI's core facilities in molecular biology, controlled environments and mass spectrometry/proteomics. We will also expand and improve the physical home of CETI by moving into new facilities that CETI has leveraged through productive partnerships with the UNM administration, and we will initiate a new seed grant program to increase the breadth and impact of CETI. We will develop multi-investigator proposals to mark CETI's graduation from NCRR funding and continue to seek new ways to promote integration and collaborations among our members and with the New Mexico research community. Lastly, CETI will increasingly serve as a catalyst to develop new training and biomedical research opportunities in our state and will use our critical mass to undertake initiatives and favor research enabling us to achieve world class recognition and prominence.

该提案以我们在第一个资助期间积累的关键专业知识和基础设施为基础，寻求通过 NCRR 的 COBRE 计划再提供五年的支持，使我们能够进一步加强和巩固一个自我维持和蓬勃发展的进化和理论免疫学中心 (CETI)。来自新墨西哥大学和洛斯阿拉莫斯国家实验室生物学和计算机科学系的初级和高级教师学者将再次开展研究项目，旨在揭示免疫系统的基本设计原理，模拟病原体和免疫系统之间的相互作用，并探索跨动物门的免疫反应的进化。因此，我们将更好地了解无脊椎动物媒介如何传播传染病、病原体如何防御免疫攻击以及免疫系统的比较研究如何产生令人兴奋的新概念框架和范式。我们还将改进我们的指导计划，以培养独立资助的初级研究人员，为我们的会员提供资助准备和管理方面的后勤支持，并利用一切机会努力改善他们的长期职业前景。我们将聘请更多与 CETI 相关的终身教授，并继续与其他 NCRR 项目和 UNM 行政部门合作，支持和改进 CETI 在分子生物学、受控环境和质谱/蛋白质组学方面的核心设施。我们还将通过迁入 CETI 通过与 UNM 行政部门富有成效的合作关系而利用的新设施来扩大和改善 CETI 的实际所在地，并且我们将启动一项新的种子拨款计划，以扩大 CETI 的广度和影响力。我们将制定多研究者提案，以纪念 CETI 从 NCRR 资助中毕业，并继续寻求新的方法来促进我们的成员之间以及与新墨西哥研究界的融合与合作。最后，CETI 将越来越多地成为在我们州开发新的培训和生物医学研究机会的催化剂，并将利用我们的关键力量来采取举措和支持研究，使我们能够获得世界级的认可和突出。