Melanoma Stem Cells, Vasculogenesis and Neoplastic Progression
黑色素瘤干细胞、血管生成和肿瘤进展
基本信息
- 批准号:8307737
- 负责人:
- 金额:$ 33.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-24 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdultBindingBreslow ThicknessCell LineCellsClinicalDiagnosisDisease ProgressionDisseminated Malignant NeoplasmDrug resistanceEarly DiagnosisEmbryoExcisionExperimental NeoplasmsFailureFamilyGene ExpressionGenesGrowthHumanHumpback DolphinsIn VitroInfiltrationKnowledgeLaboratoriesMalignant NeoplasmsMediator of activation proteinMelanoma CellMinorityModelingMolecularMolecular ProfilingMulti-Drug ResistanceNeoplasm MetastasisOperative Surgical ProceduresPathway interactionsPatientsPatternPopulationProcessRadial Growth PhaseResistanceRoleStem cellsSurvival RateSystemic TherapyTherapeuticTreatment ProtocolsTumor Stem CellsUndifferentiatedVisceralWorkXenograft procedureabstractingbasecancer stem cellcancer therapychemotherapyconventional therapyimprovedlifetime risklymph nodesmelanomamembermimicrymortalitynovelnovel strategiesnovel therapeuticsoutcome forecastself-renewaltherapy resistanttumortumor growthtumor initiationtumor progressiontumorigenesisvasculogenesis
项目摘要
Abstract:
Human melanoma is a highly aggressive and drug resistant cancer and resistant to systemic therapy once
disseminated. Findings of undifferentiated subpopulations with embryonic-like plasticity within this malignancy
have pointed to the presence of melanoma stem cells. Recently our laboratory has identified melanoma stem
cells characterized by expression of the chemoresistance mediator ABCBS, which are responsible for
melanoma progression and can be therapeutically targeted in experimental tumor xenotransplantation models.
The molecular and cellular mechanisms by which melanoma stem cells trigger tumorigenesis and promote
neoplastic progression are currently unknown. Vasculogenesis and metastasis are phenomena recognized to
be critical for tumor growth and neoplastic progression. Despite the significant knowledge about the molecular
pathways involved, a specific relationship of cancer stem cells to these processes has not been demonstrated
to date. We hypothesize that melanoma stem cells capable of self-renewal and differentiation, which are
responsible for tumor growth, may coincide with cancer subpopulations critically involved in tumor
vasculogenesis and metastasis and that specific targeting of this cell population and of related molecular
pathways could thus provide for novel strategies to eradicate cancers currently resistant to conventional
therapy. The specific aims of this proposal are the following: (1) Investigate the relationship between ABCBS+
melanoma stem cells and tumor vasculogenesis and define the molecular mechanisms involved; (2) Define the
role of ABCBS+ melanoma stem cells in metastatic neoplastic progression; and (3) Develop novel melanoma
stem cell-targeted therapies. Thus, the proposal is highly relevant to efforts directed at developing novel
therapeutic strategies to cancer therapy based on selectively targeting vital molecular pathways in cancer stem
cells.
文摘:
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of Malignant Melanoma Initiating Cells on T-Cell Activation.
恶性黑色素瘤起始细胞对 T 细胞激活的影响。
- DOI:10.1007/7651_2015_299
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Schatton,Tobias;Schütte,Ute;Frank,MarkusH
- 通讯作者:Frank,MarkusH
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Markus H. Frank其他文献
Méthodes diagnostiques et thérapeutiques se rapportant à des cellules souches cancéreuses
癌症细胞的诊断和治疗方法
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
Markus H. Frank;Natasha Y. Frank - 通讯作者:
Natasha Y. Frank
Utilisation de polynucléotides de la subtilisine (RNR9) pour obtenir une résistance à un pathogène dans les plantes
利用枯草杆菌多核苷酸 (RNR9) 获得植物病原体的抗性
- DOI:
- 发表时间:
2008 - 期刊:
- 影响因子:0
- 作者:
Markus H. Frank;P. Schweizer;Dimitar Douchkov - 通讯作者:
Dimitar Douchkov
Caveolin 1 and 2 enhance the proliferative capacity of BCAM-positive corneal progenitors
- DOI:
10.1038/s41598-024-81283-4 - 发表时间:
2025-02-24 - 期刊:
- 影响因子:3.900
- 作者:
Yuzuru Sasamoto;Shoko Kiritoshi;Catherine A. A. Lee;Yoshiko Fukuda;Gabrielle Martin;Bruce R. Ksander;Markus H. Frank;Natasha Y. Frank - 通讯作者:
Natasha Y. Frank
Procédé d'augmentation de la résistance aux champignons dans les plantes
植物中香菇抵抗力的增强过程
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
Holger Schultheiss;Markus H. Frank;Caroline Höfle - 通讯作者:
Caroline Höfle
Angiogenin Released from ABCB5sup+/sup Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis
ABCB5 阳性基质前体细胞释放的血管生成素通过促进血管生成改善糖尿病伤口愈合
- DOI:
10.1016/j.jid.2021.10.026 - 发表时间:
2022-06-01 - 期刊:
- 影响因子:5.700
- 作者:
Karmveer Singh;Pallab Maity;Albert Kallon Koroma;Abhijit Basu;Rajeev Kumar Pandey;Seppe Vander Beken;Philipp Haas;Linda Krug;Adelheid Hainzl;Anca Sindrilaru;Christiane Pfeiffer;Meinhard Wlaschek;Natasha Y. Frank;Markus H. Frank;Christoph Ganss;András Bánvölgyi;Norbert Wikonkál;Sabine Eming;Irena Pastar;Marjana Tomic-Canic;Karin Scharffetter-Kochanek - 通讯作者:
Karin Scharffetter-Kochanek
Markus H. Frank的其他文献
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{{ truncateString('Markus H. Frank', 18)}}的其他基金
Multicomponent Therapy for Age-related Skin Stem Cell Deficiency
治疗与年龄相关的皮肤干细胞缺乏症的多成分疗法
- 批准号:
10707346 - 财政年份:2022
- 资助金额:
$ 33.66万 - 项目类别:
Multicomponent Therapy for Age-related Skin Stem Cell Deficiency
治疗与年龄相关的皮肤干细胞缺乏症的多成分疗法
- 批准号:
10494654 - 财政年份:2022
- 资助金额:
$ 33.66万 - 项目类别:
Stem Cell Integral Membrane Transporter ABCB5 and Dermal Regeneration
干细胞整体膜转运蛋白 ABCB5 和真皮再生
- 批准号:
10494660 - 财政年份:2022
- 资助金额:
$ 33.66万 - 项目类别:
Stem Cell Integral Membrane Transporter ABCB5 and Dermal Regeneration
干细胞整体膜转运蛋白 ABCB5 和真皮再生
- 批准号:
10707397 - 财政年份:2022
- 资助金额:
$ 33.66万 - 项目类别:
Immunology of human malignant melanoma initiating cells
人类恶性黑色素瘤起始细胞的免疫学
- 批准号:
8532856 - 财政年份:2012
- 资助金额:
$ 33.66万 - 项目类别:
Immunology of human malignant melanoma initiating cells
人类恶性黑色素瘤起始细胞的免疫学
- 批准号:
8239174 - 财政年份:2012
- 资助金额:
$ 33.66万 - 项目类别:
Immunology of human malignant melanoma initiating cells
人类恶性黑色素瘤起始细胞的免疫学
- 批准号:
8685190 - 财政年份:2012
- 资助金额:
$ 33.66万 - 项目类别:
Immunology of human malignant melanoma initiating cells
人类恶性黑色素瘤起始细胞的免疫学
- 批准号:
9112874 - 财政年份:2012
- 资助金额:
$ 33.66万 - 项目类别:
Melanoma Stem Cells, Vasculogenesis and Neoplastic Progression
黑色素瘤干细胞、血管生成和肿瘤进展
- 批准号:
8109826 - 财政年份:2008
- 资助金额:
$ 33.66万 - 项目类别:
Melanoma Stem Cells, Vasculogenesis and Neoplastic Progression
黑色素瘤干细胞、血管生成和肿瘤进展
- 批准号:
7692241 - 财政年份:2008
- 资助金额:
$ 33.66万 - 项目类别:
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