INBRE: COLLEGE OF CHARLESTON: FACULTY & UNDERGRADUATE RESEARCH DEVELOPMENT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 一个为期四年，150万美元的HHMI赠款，由查尔斯顿学院直接收购作为SC INBRE支持的结果，提供资金开发计算生物学，神经科学和化学生物学的新课程，聘请新的教师，并提供研究支持本科生。通过将HHMI支持与SC INBRE相结合，学院将为五名教师提供研究支持，以指导HHMI和SC INBRE项目的本科生。目标是进一步增加利用生物医学科学研究培训机会的学生人数，特别是少数民族学生。该学院将聘请两名新的教师，一个是为了增加新的神经生物学计划，该计划在很大程度上是在先前的SC INBRE支持下建立的，另一个是生物化学。此外，SC INBRE将支持阿纳斯塔西娅齐默尔曼博士，目前在生物系，作为最初的目标教师。之前的SC INBRE目标教师在学院将担任当地的导师博士齐默尔曼。 查尔斯顿学院将与当地高中建立联系，将“管道”延伸到K-12竞技场。HHMI赠款将使学院能够将其外展工作扩展到附近主要是非洲裔美国人的伯克高中。INBRE的支持将用于接触圣约翰高中，这是另一所以非洲裔美国人为主的学校，大约30分钟的路程，并与其他种族混合更均匀的高中（例如，詹姆斯岛、廷伯兰、Wando和West阿什利高中）。外展工作将通过学院的向上绑定程序，旨在产生必要的技能和动力，在高中以后的教育成功，提供学术和文化的机会选定的高中新生，小学生，初中生和高年级学生从目标高中在三县地区渠道。这些学生，主要是少数民族学生，他们的父母从未完成过四年制大学学位;家庭收入使学生有资格获得免费或减少的午餐;并且已经证明了成功所需的学术潜力。学生将参加我们的INBRE教师的演讲，并在他们的研究项目的进行中为我们的本科生提供阴影，有机会参与研究的各个方面，从计划到执行实验，文献检索和报告。 学生招募和保留学院的第一年经验学习社区，其中一批学生参加了一组配对课程，具有两个医学预科部分，学生参加大一生物学和大一化学。这将使我们能够教育新生，只要他们走进门在学院的生物医学研究机会，特别是针对少数民族学生。INBRE教师将向这些班级做演讲，并与少数民族学生直接接触。招募少数民族学生参加科学培训和职业很重要，但留住少数民族学生也很重要。学院将继续积极参与南卡罗来纳州少数民族参与联盟（SCAMP）计划，该计划通过为新生提供特殊机会，如夏桥计划，提高学习技能的特殊学年计划，以额外奖学金或津贴形式的激励奖励计划，以及适当的社会活动，增加少数民族学生成功的机会。SC INBRE的教职员工每年秋季都会在SCAMP会议上发表演讲，讨论研究机会。这种互动已经导致几个感兴趣的学生进入研究实验室的位置。我们计划每年邀请一个或多个少数民族发言人，包括我们的校友，在学院举办研讨会，为我们的少数民族学生提供榜样。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A four-year, $1.5 million HHMI grant, acquired by the College of Charleston directly as an outcome of SC INBRE support, provides funds to develop new courses in computational biology, neuroscience, and chemical biology, to hire new faculty members, and to provide research support to undergraduate students. By coupling HHMI support with SC INBRE's, the College will provide research support for five faculty members to mentor undergraduate students both from the HHMI and SC INBRE programs. The objective is to further increase the number of students who take advantage of research training opportunities in biomedical science, and in particular to do so with minority students. The College will hire two new faculty members, one to augment the new Neurobiology program established in great part with prior SC INBRE support, and the other in Biochemistry. In addition, SC INBRE will support Dr. Anastasia Zimmermann, currently in the Biology Department, as an initial Target Faculty. Prior SC INBRE Target faculty at the College will serve as local mentors to Dr. Zimmerman. Outreach to High Schools for Minority Student Recruitment The College of Charleston will establish links with local high schools to extend the "pipeline" to the K-12 arena. The HHMI grant will enable the College to extend its outreach efforts to nearby predominantly African-American Burke High School. INBRE support will be used to reach out to St. Johns High School, another predominantly African American school that is about thirty minutes away, and also to explore opportunities with other high schools that are more evenly racially mixed (e.g., James Island, Timberland, Wando, and West Ashley High Schools). Outreach efforts will be channeled through the College's Upward Bound Program, a pre-collegiate program designed to generate the skills and motivation necessary for success in education beyond high school, providing academic and cultural opportunities for selected high school freshmen, sophomores, juniors and seniors from target high schools in the Tri-county area. These students, primarily minority students, have parents that have never completed a four year college degree; a family income that qualifies the student for free or reduced lunch; and have demonstrated the academic potential needed to be successful. Students will attend presentations from our INBRE faculty and shadow our undergraduates in the conduction of their research projects, with opportunities for participating in all aspects of the research, from planning to execution of the experiments, literature searches, and reports. Student Recruitment and Retention The College's First Year Experience learning communities, where a cohort of students are enrolled in a set of paired courses, features two pre-Med sections where students are enrolled in both freshman biology and freshman chemistry. This will enable us to educate freshman as soon as they walk in the door about the biomedical research opportunities at the College and in particular to target minority students. INBRE faculty will make presentations to these classes and will make direct contact with minority students. Recruitment of minority students into scientific training and careers is important, but so is retention. The College will continue to be an active participant in the South Carolina Alliance for Minority Participation (SCAMP) program which increases the chances of success for minority students by providing special opportunities such as a summer bridge program for incoming students, special academic year programs to sharpen study skills, an incentive rewards program in the form of additional scholarships or stipends, and appropriate social activities. SC INBRE faculty members have been making presentations at a SCAMP meeting each fall to discuss research opportunities. This interaction has already resulted in the placement of several interested students into research labs. We plan to annually invite one or more minority speakers, including our alumni, to give seminars at the College, to provide role models for our minority students.