NANOSTRUCTURED CARBON NANOTUBE/HYDROXYAPATITE AND CARBON NANOTUBE/TITANIA (TIO2)

纳米结构碳纳米管/羟基磷灰石和碳纳米管/二氧化钛 (TIO2)

• 批准号: 8359821
• 负责人: FRANKLIN HARDCASTLE
• 金额: $ 2.06万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359821
• 关键词: Area; Arkansas; Biomedical Research; Calcium; Carbon Nanotubes; Chemicals; Deposition; Exhibits; Film; Funding; Grant; HA coating; High temperature of physical object; Human; Hydroxyapatites; Implant; Metals; Methods; National Center for Research Resources; Particle Size; Phase; Plasma; Potentiometry; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Resources; Scanning Electron Microscopy; Solutions; Source; Surface; Techniques; Thick; Titania; Titanium; United States National Institutes of Health; X ray diffraction analysis; X-Ray Diffraction; anatase titanium dioxide; biomaterial compatibility; bone; cost; improved; inorganic phosphate; nanoparticle; nanostructured; repaired; rutile; sample fixation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Nanostructured Carbon Nanotube / Hydroxyapatite and Carbon Nanotube / Titania (TiO2) Composite Films by Electrophoretic Deposition (EPD) Metallic implants have been used for many years to repair and replace bone. More recently, studies have been directed at improving implant fixation by using physical as well as chemical methods. Calcium hydroxy phosphate (better known as hydroxyapatite, or HAP), as a deposited thin layer on titanium implants, exhibits excellent biocompatibility because of its similarity to human bone. However, HAP coatings are currently deposited by high-temperature plasma spraying techniques that result in unpredictable films consisting of undefined phases (chemical composition unknown) and undesirable thick films (causing micro-cracking). We propose using the solution-phase technique of electrophoretic deposition (EPD) to produce high-quality and reproducible coatings on titanium metal substrates. The coatings will consist of nanoparticles of hydroxyapatite (HAP), rutile and anatase forms of TiO2, and carbon nanotubes (CNT). The nanoparticles will be characterized using particle-size analysis, zeta potentiometry, BET surface-area, and spectroscopic techniques. The composite coatings that will be produced consist of HAP/CNT, rutile/CNT, anatase/CNT, and HAP/TiO2/CNT. These coatings will be examined using Raman spectroscopy, FT-IR, X-ray diffraction, and scanning electron microscopy (SEM).

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 电泳沉积纳米结构碳纳米管/羟基磷灰石和碳纳米管/二氧化钛复合薄膜 金属植入物已用于修复和替换骨多年。最近，研究已经针对通过使用物理和化学方法来改善植入物固定。羟基磷酸钙（更好地称为羟基磷灰石，或HAP），作为钛植入物上的沉积薄层，由于其与人骨的相似性而表现出优异的生物相容性。然而，HAP涂层目前是通过高温等离子喷涂技术沉积的，这导致由不确定的相（化学成分未知）和不期望的厚膜（导致微裂纹）组成的不可预测的膜。 我们建议使用电泳沉积（EPD）的溶液相技术在钛金属基材上生产高质量和可重复的涂层。涂层将由纳米羟基磷灰石（HAP），金红石和金红石型TiO 2和碳纳米管（CNT）组成。纳米颗粒将使用粒度分析、zeta电位测定法、BET表面积和光谱技术进行表征。制备的复合涂层包括HAP/CNT、金红石/CNT、TiO 2/CNT和HAP/TiO 2/CNT。将使用拉曼光谱、FT-IR、X射线衍射和扫描电子显微镜（SEM）检查这些涂层。