NEURO-COGNITIVE SELF-REGULATION MECHANISMS AND THEIR RELATION TOOBESITY

神经认知自我调节机制及其与肥胖的关系

• 批准号: 8359626
• 负责人: STEVEN B MOST
• 金额: $ 10.11万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359626
• 关键词: Attention; Behavior; Behavioral; Benchmarking; Biotechnology; Characteristics; Clinical; Cognitive; Cues; Data; Delaware; Exhibits; Food; Funding; Future; Grant; Individual; Informal Social Control; Institutes; Intervention; Investigation; Life Style; Measures; Methods; National Center for Research Resources; Outcome; Pediatric Hospitals; Physiological; Population; Principal Investigator; Relative (related person); Research; Research Infrastructure; Resources; Self-control as a personality trait; Short-Term Memory; Source; Staging; Testing; Training; Treatment Efficacy; United States National Institutes of Health; Universities; Weight; Work; cognitive control; cost; graduate student; indexing; meetings; relating to nervous system; response; shift work

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Meeting benchmarks of successful weight management intervention requires that individuals make difficult choices, often involving challenging and sustained efforts of self-control. The proposed research will investigate whether individuals struggling with weight management exhibit characteristic neuro-cognitive indices related to attentional- and self-control and  because intervention often involves effortful implementation of sustained lifestyle changes  whether such indices might additionally predict intervention outcomes within a population of such individuals. The following are among the questions to be tested: (1) Do individuals struggling with weight management exhibit marked impulsiveness or difficulties involving attention shifting, working memory, and the inhibition of otherwise reflexive behaviors? Do such indices correlate with objective measures such as BMI and efficacy of intervention over the course of treatment? (2) Are weight management problems accompanied by exaggerated affectively-driven neural responses to food cues and/or by a relative inability to regulate such responses? (3) Do common food cues, such as appetitive aromas generally negatively impact cognitive control functions? These issues will be investigated through the use of objective and proven neuro-physiological and behavioral methods. It is anticipated that data obtained in the initial stages of investigation will set the stage for future funding and research, as well as for building further bridges between the University of Delaware, the A.I duPont Hospital for Children, and INBRE core centers at the Delaware Biotechnology Institute. Furthermore, this project will provide a unique training opportunity for undergraduate and graduate students wishing to work at the interface between clinical and neuro-cognitive research.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 满足成功的体重管理干预的基准要求， 做出艰难的选择，通常涉及具有挑战性和持续的自我控制努力。的 一项拟议中的研究将调查那些努力控制体重的人 表现出与注意力和自我控制相关的特征性神经认知指数，  因为干预往往涉及到持续的生活方式改变的努力实施  这些指数是否可以额外预测人群中的干预结果， 这样的个人。 以下是要测试的问题：（1）个人是否 体重管理的挣扎表现出明显的冲动或困难， 注意力转移、工作记忆和对其他反射行为的抑制？ 做这样 指数与客观指标相关，如BMI和干预的有效性。 治疗过程？ (2)体重管理问题是否伴随着夸张的 对食物线索的情感驱动的神经反应和/或相对无法调节这种反应 回应？ (3)常见的食物线索，如食欲的香味，通常会产生负面影响， 认知控制功能 这些问题将通过使用客观和 经过验证的神经生理学和行为学方法。 预计， 调查的初始阶段将为未来的资金和研究奠定基础， 在特拉华州大学、A.I杜邦医院之间建立更多的桥梁， 儿童和特拉华州生物技术研究所的INBRE核心中心。 而且这 该项目将为本科生和研究生提供一个独特的培训机会 希望在临床和神经认知研究之间的接口工作。