Non-canonical olfactory and vomeronasal receptors

项目摘要 嗅觉神经回路产生数万种不同的感知和影响 先天行为，如进食，在许多哺乳动物中，信息素的反应 就像打架和交配。哺乳动物有两种主要的嗅觉组织：主要嗅觉 上皮和犁鼻器，每一个都包含大家族 专门的感官感受器并激活不同的神经元回路。我们最近 鉴定出两个非规范的哺乳动物化学感受器家族，它们是 有别于先前描述的气味和犁鼻受体。在这份提案中， 我们的目标是了解细胞的进化、细胞组织和化学感受野。 这些新的感觉受体，提供了对分子的额外洞察 哺乳动物嗅觉的基础机制。

Project Summary Olfactory neural circuits generate tens of thousands of distinct perceptions and influence innate behaviors, such as feeding, and in many mammals, pheromone responses such as fighting and mating. Mammals have two principal olfactory tissues: the main olfactory epithelium and the vomeronasal organ, each of which contains large families of dedicated sensory receptors and activates distinct neuronal circuits. We recently identified two non-canonical families of mammalian chemosensory receptors that are distinct from previously described odorant and vomeronasal receptors. In this proposal, we aim to understand the evolution, cellular organization, and chemoreceptive fields of these novel sensory receptors, to provide additional insight into the molecular mechanisms that underlie olfaction in mammals.