Biomechanical characterization of vocal fold tissues

声带组织的生物力学特征

• 批准号: 8284428
• 负责人: ROGER W CHAN
• 金额: $ 40.36万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8284428
• 关键词: Address; American; Area; Biomechanics; Characteristics; Cicatrix; Clinical; Communication; Computer Simulation; Data; Data Set; Diagnosis; Extracellular Matrix; Fatigue; Frequencies; Goals; Guidelines; Health; Health Care Costs; Human; Human Characteristics; Image; Injection of therapeutic agent; Lamina Propria; Laryngeal muscle structure; Larynx; Literature; Mechanics; Mental Health; Modeling; Occupations; Pathogenesis; Patients; Phonation; Posture; Prevention; Procedures; Production; Property; Quality of life; Regulation; Research; Safety; Social Functioning; Societies; Tissues; Trauma; Voice; Voice Disorders; economic impact; improved; response; tool; vibration; vocal cord

DESCRIPTION (provided by applicant): This project represents a continual effort to quantify the key biomechanical characteristics of human laryngeal tissues, so as to better understand the tissue mechanics of voice production, the potential mechanical factors responsible for voice disorders related to vocal overuse and trauma, and the mechanical manifestations of vocal fold scarring. The long-term goal is to provide mechanics-motivated guidelines for improving the prevention, diagnosis and management of voice disorders. To achieve this goal, the specific aims of this application include: (1) To quantify the linear and nonlinear viscoelastic response of the vocal fold lamina propria extracellular matrix (ECM), including to quantify the tissue fatigue response contributing to the safety limits of accumulated vibration exposure in the vocal fold ECM, and to quantify the viscoelastic shear properties of human vocal fold scar tissues; (2) To characterize the active contractile properties and passive viscoelastic properties of human intrinsic laryngeal muscles; (3) To develop new constitutive models of the vocal fold lamina propria and the intrinsic laryngeal muscles for more accurate descriptions of their tissue mechanics; and (4) To develop new biomechanical models for fundamental frequency regulation and prediction; as well as to integrate the new empirical data and new constitutive models with existing computational biomechanical models of vocal fold posturing and phonation. A major benefit of this research will be an improvement in the computer models of vocal fold posturing and phonation, such that they will become more accurate, more consistent and more representative of human voice production. Such models can potentially become a powerful clinical tool for maximizing the vocal function of patients undergoing phonosurgical procedures, such as thyroplasty, injection laryngoplasty and minithyrotomy for the treatment of a variety of voice disorders. PUBLIC HEALTH RELEVANCE: Up to 9% of Americans suffer from some kind of voice disorders annually. The economic impact of voice disorders cannot be overstated, as up to around 20% of the U.S. workforce relies on a healthy, functional voice as a major tool for their occupations (Titze et al., 1997). It has also been well documented that voice disorders have a significant negative impact on the quality of life in the areas of communication, social function and psychological health. By improving our understanding of the tissue mechanics of voice production, the potential mechanical factors responsible for voice disorders related to vocal overuse and trauma, and the mechanical manifestations of vocal fold scarring, this research may contribute findings that could improve the prevention, diagnosis and management of voice disorders, reducing the burden of excessive healthcare costs on society.

描述（由申请人提供）：该项目代表了量化人类喉部组织关键生物力学特征的持续努力，以便更好地了解发声的组织力学、与声音过度使用和创伤相关的声音障碍的潜在机械因素，以及声带疤痕的机械表现。长期目标是提供力学驱动的指南，以改善嗓音疾病的预防、诊断和管理。为了实现这一目标，本申请的具体目标包括：（1）量化声带固有层细胞外基质（ECM）的线性和非线性粘弹性响应，包括量化声带ECM中累积振动暴露的安全极限的组织疲劳响应，以及量化人类声带疤痕组织的粘弹性剪切特性； (2)表征人体喉固有肌的主动收缩特性和被动粘弹特性； (3) 开发新的声带固有层和喉固有肌的本构模型，以更准确地描述其组织力学； (4) 开发用于基频调节和预测的新生物力学模型；以及将新的经验数据和新的本构模型与现有的声带姿势和发声的计算生物力学模型相结合。这项研究的一个主要好处是改进声带姿势和发声的计算机模型，使它们变得更准确、更一致、更能代表人类的声音产生。这种模型有可能成为一种强大的临床工具，用于最大限度地提高接受语音外科手术的患者的发声功能，例如用于治疗各种声音障碍的甲状软骨成形术、注射喉成形术和小型甲状腺切开术。公共卫生相关性：每年有高达 9% 的美国人患有某种嗓音疾病。嗓音障碍的经济影响怎么强调都不为过，因为多达 20% 左右的美国劳动力依赖健康、功能性的嗓音作为其职业的主要工具（Titze 等，1997）。还有充分证据表明，嗓音障碍对沟通、社会功能和心理健康领域的生活质量具有显着的负面影响。通过提高我们对发声组织力学、与发声过度使用和创伤相关的发声障碍的潜在机械因素以及声带疤痕的机械表现的理解，这项研究可能会提供改善发声障碍的预防、诊断和管理的发现，从而减轻社会过度医疗费用的负担。

项目成果

The anisotropic hyperelastic biomechanical response of the vocal ligament and implications for frequency regulation: a case study.

声带韧带的各向异性超弹性生物力学响应及其对频率调节的影响：案例研究。

• DOI: 10.1121/1.4776204
• 发表时间: 2013
• 期刊: The Journal of the Acoustical Society of America
• 作者: Kelleher,JordanE;Siegmund,Thomas;Du,Mindy;Naseri,Elhum;Chan,RogerW
• 通讯作者: Chan,RogerW

A bovine acellular scaffold for vocal fold reconstruction in a rat model.

用于大鼠模型声带重建的牛脱细胞支架。

• DOI: 10.1002/jbm.a.32279
• 发表时间: 2010
• 期刊: Journal of biomedical materials research. Part A
• 作者: Xu,ChetC;Chan,RogerW;Weinberger,DebraG;Efune,Guy;Pawlowski,KarenS
• 通讯作者: Pawlowski,KarenS

Three-dimensional conformation of the injected bolus in vocal fold injections in a cadaver model.

尸体模型声带注射中注射团的三维构象。

• DOI: 10.1177/0194599810395107
• 发表时间: 2011
• 期刊: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
• 作者: Mau,Ted;Brewer,JacquelynM;Gatzert,SamuelT;Courey,MarkS
• 通讯作者: Courey,MarkS

Viscoelastic properties of human aryepiglottic fold and ventricular fold tissues at phonatory frequencies.

• DOI: 10.1002/lary.27049
• 发表时间: 2018-08
• 期刊: The Laryngoscope
• 作者: Kimura M;Chan RW
• 通讯作者: Chan RW

Collagen Injection as a Supplement to Arytenoid Adduction for Vocal Fold Paralysis

胶原注射作为杓状腱内收的补充治疗声带麻痹

• DOI: 10.1177/000348940811700605
• 发表时间: 2008
• 期刊: Annals of Otology, Rhinology & Laryngology
• 作者: M. Kimura;T. Nito;H. Imagawa;N. Tayama;R. Chan
• 通讯作者: R. Chan