10th International Catecholamine Symposium (XICS)

第十届国际儿茶酚胺研讨会（XICS）

• 批准号: 8386777
• 负责人: DANIEL T O'CONNOR
• 金额: $ 1.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8386777
• 关键词: Alcohol abuse; Ally; Anabolism; Animal Model; Basic Science; Bioinformatics; Biology; Cardiovascular Diseases; Cardiovascular system; Catecholamines; Cells; Cellular biology; Chemicals; Clinical; Clinical Medicine; Diabetes Mellitus; Diagnosis; Discipline; Disease; Dopamine; Drug Addiction; Drug abuse; Endocrine System Diseases; Ensure; Epinephrine; Family; Fostering; Functional disorder; Gene Delivery; Genetic; Genomics; Goals; Image; Institutes; Integrative Medicine; International; Internet; Mental disorders; Metabolism; Minority; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Drug Abuse; National Institute of Neurological Disorders and Stroke; Neurologic; Neurology; Neurons; Neuropharmacology; Norepinephrine; Optics; Oral; Parkinson Disease; Participant; Pathogenesis; Patients; Peripheral; Pharmaceutical Preparations; Physiology; Play; Postdoctoral Fellow; Prevention; Psychiatry; Psychology; Public Health; Research; Research Personnel; Role; Scientist; Series; Site; Stress; Students; Subcellular Fractions; Support Groups; System; Time; United States National Institutes of Health; Update; Women Status; clinical practice; design; graduate student; innovation; interest; meetings; member; minority trainee; multidisciplinary; nervous system disorder; neurochemistry; new technology; patient oriented; posters; pre-doctoral; professor; programs; receptor; reuptake; symposium; trafficking; web site

DESCRIPTION (provided by applicant): 10th International Catecholamine Symposium (XICS), Asilomar Conference Grounds, September 8-13, 2012. The XICS will bring together about 400 basic, disease-oriented, and patient-oriented researchers to present and discuss advances in understanding of catecholamine-related disorders. Catecholamines are well known to play crucial roles in a wide variety of conditions that impact public health, including drug and alcohol abuse and neurologic, psychiatric, cardiovascular, and endocrine disorders. Since catecholamine research formats span from subcellular fractions to cells and neurons to animal models and patients, research on this small chemical family is truly translational. The general field of catecholamine research has not undergone comprehensive review for 10 years. During this interval, a tremendous amount of new information has accrued about the important involvement of catecholamine systems in a host of topics of direct interest to multiple Institutes of the NIH, such as NIDA, NINDS, and NIDDK. The XICS will emphasize integration of basic science with clinical pathophysiology, by a program centering on disease- oriented research about catecholamine systems. The ten carefully selected Themes of the XICS are synthesis and storage, release and reuptake, metabolism, receptors, neurology, psychiatry and psychology, drug abuse, peripheral catecholamine systems, integrative medicine, and interactions with other transmitters. Participants in the XICS will include an international, diverse mixture of senior and junior scientists, pre- and post-doctoral trainees, minorities and students, and patients with catecholamine-related disorders. A specific minority action program is in place. This application conveys five Specific Aims designed to implement our goals in the practical setting of the meeting. PUBLIC HEALTH RELEVANCE: Members of the catecholamine chemical family-dopamine, norepinephrine, and adrenaline-play many key roles in normal physiology, drug effects, stress, and a variety of important neurological, cardiovascular, psychiatric, and endocrine disorders. The overall goal of the XICS is to provide a comprehensive update of advances in understanding of catecholamine biosynthesis, trafficking, storage, release, metabolism, actions, and involvement in the pathophysiology, pathogenesis, diagnosis, treatment, and prevention of catecholamine-related disorders, such as Parkinson disease, drug addiction, and diabetes. The XICS will continue a remarkably successful series that began at the NIH in Bethesda about a half century ago.

描述(申请人提供)：第十届国际儿茶酚胺研讨会(XICS)，Asilomar会议场地，2012年9月8-13日。XICS将汇集大约400名基础的、以疾病为导向和以患者为导向的研究人员，介绍和讨论对儿茶酚胺相关疾病的理解进展。众所周知，儿茶酚胺在影响公众健康的各种情况下发挥着关键作用，包括毒品和酒精。 虐待和神经学、精神病学、心血管和内分泌紊乱。由于儿茶酚胺的研究形式从亚细胞组分到细胞和神经元，再到动物模型和患者，对这个小化学家族的研究真正是翻译的。儿茶酚胺的一般研究领域已经10年没有进行过全面的综述了。在此期间，积累了大量关于儿茶酚胺系统在NIH多个研究所直接感兴趣的主题中的重要参与的新信息，如NIDA、NINDS和NIDDK。XICS将通过一个以疾病为中心的对儿茶酚胺系统的研究计划，强调基础科学与临床病理生理学的结合。XICS精心挑选的十个主题是合成和储存、释放和再摄取、新陈代谢、受体、神经学、精神病学和心理学、药物滥用、外周儿茶酚胺系统、综合医学以及与其他递质的相互作用。XICS的参与者将包括国际上不同的高级和 初级科学家、博士后和博士后实习生、少数民族和学生，以及儿茶酚胺相关疾病患者。已经制定了一个具体的少数群体行动计划。这个应用程序传达了五个具体目标，旨在在会议的实际环境中实现我们的目标。 与公共健康相关：儿茶酚胺化学家族的成员--多巴胺、去甲肾上腺素和肾上腺素--在正常生理、药物效应、应激以及各种重要的神经、心血管、精神和内分泌疾病中发挥着许多关键作用。XICS的总体目标是全面了解儿茶酚胺的生物合成、贩运、储存、释放、代谢、作用以及参与儿茶酚胺相关疾病的病理生理、发病机制、诊断、治疗和预防的最新进展，如帕金森病、药物成瘾和糖尿病。XICS将继续大约半个世纪前在贝塞斯达的NIH开始的一个非常成功的系列。