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Neuropsychopharmacology Training for Drug Abuse Research

药物滥用研究的神经精神药理学培训

基本信息

批准号：
8532565
负责人：
Paul R Vezina
金额：
$ 17.85万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-09-30 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8532565
关键词：
Drug abuse Research Training

项目摘要

DESCRIPTION (provided by applicant): The overall objective of the NIDA Training Program in Drug Abuse Research at The University of Chicago is to provide both pre- and postdoctoral trainees with comprehensive educational and research experiences that will enable them to pursue distinguished research careers in areas impacting drug abuse. Drug abuse poses a serious threat to the health and well being of both individuals and society. Mental status, physical health, social function and economic productivity are compromised. Such factors can lead to an increase in crime and violence. To the credit of NIDA-sponsored research programs, considerable gains have been made over the last two decades. However, much more remains to be learned from the molecular to the social realm, especially if knowledge is to be translated into effective treatment. Existing programs in the area of drug abuse at The University of Chicago are designed to acquire knowledge about the social, behavioral, neuropharmacological, molecular and genetic factors relevant to the abuse of drugs. The aim is to increase our understanding of the etiology of and our ability to intervene in the treatment and prevention of drug abuse. Specific strengths of this program relate to the neuropharmacology, psychopharmacology, electrophysiology, genetics and molecular biology of drug abuse as well as the behavioral and subjective effects of drugs in humans. Several factors place the faculty submitting this application in an excellent position to continue to offer an outstanding training program. These factors include the strength of current interests and ongoing research into the problems of drug abuse, the diversity of approaches employed by individual faculty, the presence of a critical mass of creative scientists working on drug abuse related problems in a multidisciplinary setting as well as a curriculum that addresses the broad aspects of drug abuse ranging from the molecular bases of drug action to the consideration of ethical and social issues related to drug taking.

描述（由申请人提供）：NIDA药物滥用研究培训计划在芝加哥大学的总体目标是提供前和博士后学员全面的教育和研究经验，使他们能够追求杰出的研究事业在影响药物滥用的领域。药物滥用对个人和社会的健康和福祉构成严重威胁。精神状况、身体健康、社会功能和经济生产力受到损害。这些因素可能导致犯罪和暴力增加。由于NIDA赞助的研究项目，在过去的二十年里取得了相当大的进展。然而，从分子到社会领域还有更多的东西要学，特别是如果知识要转化为有效的治疗。芝加哥大学药物滥用领域的现有方案旨在获得与药物滥用有关的社会，行为，神经药理学，分子和遗传因素的知识。其目的是提高我们对药物滥用病因的认识和我们干预治疗和预防药物滥用的能力。该计划的具体优势涉及药物滥用的神经药理学，精神药理学，电生理学，遗传学和分子生物学以及药物对人类的行为和主观影响。有几个因素使提交此申请的教师处于有利地位，可以继续提供出色的培训计划。这些因素包括对药物滥用问题的当前兴趣和正在进行的研究的力量，个别教师采用的方法的多样性，有足够数量的富有创造力的科学家在多学科环境中研究药物滥用相关问题，课程涉及药物滥用的广泛方面，从药物作用的分子基础到对伦理和社会问题的考虑，与吸毒有关的问题。

项目成果

期刊论文数量（112）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition.

通过瞬态CAMKII抑制作用持续逆转苯丙胺摄入量。

DOI：
10.1523/jneurosci.4386-13.2013
发表时间：
2013-01-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Loweth JA;Li D;Cortright JJ;Wilke G;Jeyifous O;Neve RL;Bayer KU;Vezina P
通讯作者：
Vezina P

Mice selectively bred for High and Low fear behavior show differences in the number of pMAPK (p44/42 ERK) expressing neurons in lateral amygdala following Pavlovian fear conditioning.

选择性培育高恐惧行为和低恐惧行为的小鼠在巴甫洛夫恐惧条件反射后，外侧杏仁核中表达 pMAPK (p44/42 ERK) 的神经元数量存在差异。

DOI：
10.1016/j.nlm.2013.06.010
发表时间：
2014
期刊：
Neurobiology of learning and memory
影响因子：
2.7
作者：
Coyner,Jennifer;McGuire,JenniferL;Parker,ClarissaC;Ursano,RobertJ;Palmer,AbrahamA;Johnson,LukeR
通讯作者：
Johnson,LukeR

Btbd3 expression regulates compulsive-like and exploratory behaviors in mice.

Btbd3 表达调节小鼠的强迫样行为和探索行为。

DOI：
10.1038/s41398-019-0558-7
发表时间：
2019
期刊：
Translational psychiatry
影响因子：
6.8
作者：
Thompson,SummerL;Welch,AmandaC;Ho,EmilyV;Bessa,JoãoM;Portugal-Nunes,Carlos;Morais,Mónica;Young,JaredW;Knowles,JamesA;Dulawa,StephanieC
通讯作者：
Dulawa,StephanieC

Chimeric GABAA/glycine receptors: expression and barbiturate pharmacology.

嵌合 GABAA/甘氨酸受体：表达和巴比妥药理学。