Human Sample Acquisition Core (HSAC)

人体样本采集核心 (HSAC)

• 批准号: 8555284
• 负责人: KENNETH J. PIENTA
• 金额: $ 13.78万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555284
• 关键词: Address; Aspirate substance; Autopsy; Biopsy; Blood; Bone Marrow; Cells; Clinic; Clinical; Collection; Consent; Ensure; Human; Individual; Informatics; Leukocytes; Malignant neoplasm of prostate; Mesenchymal; Metastatic Neoplasm to the Bone; Michigan; Pathologist; Pathology; Patient Participation; Process; Prostate; Research Infrastructure; Resources; Sampling; Serum; Tissue Banking; Tissue Banks; Tissues; Translational Research; Universities; human biological material; neoplastic cell; operation; programs; quality assurance

The aim of the TMEN Human Sample Acquisition Core (HSAC) is the collection of human biological material with associated clinical information to facilitate translational research of the individual projects. This core will build on the already existing resources of the University of Michigan Prostate SPORE to make the best use of available resources. Quality assurance is maintained through the staff of the Prostate SPORE pathologists. Clinical consent and patient participation is conducted by Dr. Pienta through the Prostate Cancer Clinic at the University of Michigan. The informatics infrastructure of the Human Sample Acquisition Core is provided by an instance of caTissue as hosted by the Prostate SPORE and is coordinated by the Directors of the Division of Pathology Informatics. Specifically, the aim of the HSAC is to (i) collect blood for circulating tumor cells, white blood cells, and serum, (Ii) to collect bone marrow from aspirates and biopsies for mesenchymal cells, disseminated tumor cells and serum, and (iii) collect metastatic tissue from the University of Michigan Rapid Autopsy Program (RAP). Support for tissue banking and collection of tissue from the RAP is provided by the SPORE. Support is only being requested to collect and process blood and bone marrow.

TMEN 人类样本采集核心 (HSAC) 的目的是收集人类生物样本 具有相关临床信息的材料，以促进各个项目的转化研究。 该核心将建立在密歇根大学前列腺 SPORE 现有资源的基础上 充分利用可用资源。质量保证是通过员工来维持的 前列腺孢子病理学家。临床同意和患者参与由 Pienta 博士进行 通过密歇根大学前列腺癌诊所。信息学基础设施 人类样本采集核心由前列腺托管的 caTissue 实例提供 SPORE 并由病理信息学部门主任协调。 具体来说，HSAC 的目的是 (i) 收集血液以获取循环肿瘤细胞、白细胞和 血清，(Ii) 从抽吸物和活检中收集骨髓以获取间充质细胞，并进行传播 肿瘤细胞和血清，以及（iii）从密歇根大学快速尸检收集转移组织 计划（RAP）。对组织库和从 RAP 收集组织的支持由 孢子。仅请求支持收集和处理血液和骨髓。