The JAK2 V617F mutation within B cells and T cells leads to a pro-tumor microenvironment
The JAK2 V617F mutation within B cells and T cells leads to a pro-tumor microenvironment
批准号:
9903606
负责人:
KENNETH J. PIENTA
金额:
$7.38万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-08-29 至 2021-07-31
关键词:
AddressAdhesivesArizonaB-LymphocytesBiologicalBiomedical EngineeringBiophysicsCancer BiologyCancer CenterCancer PatientCell AdhesionCellsCessation of lifeClinicalClinical MedicineCollaborationsCollagenCuesDNA Sequence AlterationDisseminated Malignant NeoplasmDistantDrug resistanceEcologyEngineeringEpigenetic ProcessHypoxiaIndividualJAK2 geneLaboratoriesLeadershipLifeMediatingMethodsModificationMolecularMutationNeoplasm MetastasisOrganOxygenPennsylvaniaPhysicsPilot ProjectsPrimary NeoplasmPublishingRoleScientistT-LymphocyteTherapeuticTumor Cell InvasionUniversitiesWashingtonanticancer researchbiophysical techniquescancer cellepigenomicsextracellularinnovationinsightmechanical forcemedical schoolsmigrationoncologyoutcome forecastphysical sciencepreventsarcomastemsuccess
中文摘要
在与华盛顿大学医学院的癌细胞生物学家和
宾夕法尼亚州艾布拉姆森癌症中心的科学家,以及亚利桑那大学的计算生物药理学家,
约翰霍普金斯大学的生物工程师和临床医生建议创建约翰霍普金斯物理
肿瘤科学中心(PSOC)。该方案支助业务委员会将制定一种综合办法,
定量了解介导缺氧原发性肿瘤局部侵袭到远处的力
器官,通过单个和集体侵入基质基质和局限迁移沿着局限
跟踪,一些早期的关键步骤,在转移级联。为了解决复杂的组合
缺氧,基质微结构和限制对肿瘤细胞侵袭的影响,我们已经开发了三个
相关项目。计算生物药理学家将建立一个计算核心,
对转移级联中的力的定量理解。PSOC项目将分享创新
生物物理方法和专家。该PSOC采用跨学科的综合方法,将
物理学,生物医学工程,癌症生物学,生态学和临床医学领域,以改变我们的
了解转移性癌症,为预后和治疗开辟新的范例。
英文摘要
In collaboration with cancer cell biologists at the Washington University School of Medicine and the University
of Pennsylvania Abramson Cancer Center, as well as computational biophysicists at the University of Arizona,
bioengineers and clinicians at Johns Hopkins University propose to create the Johns Hopkins Physical
Sciences Oncology Center (PSOC). This PSOC will develop an integrated approach for a systematic,
quantitative understanding of the forces mediating local invasion from the hypoxic primary tumor to distant
organs, through single and collective invasion into the stromal matrix and confined migration along confining
tracks, some of the early critical step in the metastatic cascade. To address the complexity of the combined
effects of hypoxia, matrix microstructure and confinement on tumor cell invasion, we have developed three
inter-related projects. Computational biophysicists will establish a computational core to systematically develop
a quantitative understanding of forces in the metastatic cascade. PSOC projects will share innovative
biophysical methods and experts. This PSOC takes a trans-disciplinary, integrated approach, combining the
fields of physics, biomedical engineering, cancer biology, ecology, and clinical medicine, to transform our
understanding of metastatic cancer, opening new paradigms for prognosis and treatment.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The Johns Hopkins Physical Sciences Oncology Center
-
批准号:9753736
-
项目类别:
-
资助金额:$174.51万
-
财政年份:2016
-
负责人:KENNETH J. PIENTA
-
依托单位:
The Johns Hopkins Physical Sciences Oncology Center
-
批准号:9339630
-
项目类别:
-
资助金额:$211.84万
-
财政年份:2016
-
负责人:KENNETH J. PIENTA
-
依托单位:
The Johns Hopkins Physical Sciences Oncology Center
-
批准号:10016193
-
项目类别:
-
资助金额:$202.01万
-
财政年份:2016
-
负责人:KENNETH J. PIENTA
-
依托单位:
Human Sample Acquisition Core (HSAC)
-
批准号:8555284
-
项目类别:
-
资助金额:$13.78万
-
财政年份:2011
-
负责人:KENNETH J. PIENTA
-
依托单位:
Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression
-
批准号:8139125
-
项目类别:
-
资助金额:$55.23万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
-
批准号:8173854
-
项目类别:
-
资助金额:$99.71万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression
-
批准号:7978318
-
项目类别:
-
资助金额:$57.39万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
-
批准号:8173853
-
项目类别:
-
资助金额:$99.71万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression
-
批准号:8537843
-
项目类别:
-
资助金额:$52.45万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
Annual Meeting for the Clinical Research Ethics Key Function Committee
-
批准号:7916113
-
项目类别:
-
资助金额:$2.5万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1)
-
批准号:8173855
-
项目类别:
-
资助金额:$802.71万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
-
批准号:8173852
-
项目类别:
-
资助金额:$9.97万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression
-
批准号:8320749
-
项目类别:
-
资助金额:$30.77万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
-
批准号:8173856
-
项目类别:
-
资助金额:$9.97万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression
-
批准号:8658562
-
项目类别:
-
资助金额:$21.46万
-
财政年份:2010
-
负责人:KENNETH J. PIENTA
-
依托单位:
MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)
-
批准号:7961844
-
项目类别:
-
资助金额:$50.73万
-
财政年份:2009
-
负责人:KENNETH J. PIENTA
-
依托单位:
SPORE in Prostate Cancer
-
批准号:7845920
-
项目类别:
-
资助金额:$16.35万
-
财政年份:2009
-
负责人:KENNETH J. PIENTA
-
依托单位:
Carryover from year -09 for Phase II Evaluation of EMD 12194
-
批准号:7680672
-
项目类别:
-
资助金额:$5.92万
-
财政年份:2008
-
负责人:KENNETH J. PIENTA
-
依托单位:
Administration Core
-
批准号:7468647
-
项目类别:
-
资助金额:$26.97万
-
财政年份:2008
-
负责人:KENNETH J. PIENTA
-
依托单位:
Michigan Institute for Clinical and Health Research (MICHR) (TL1)
-
批准号:7675407
-
项目类别:
-
资助金额:$63.06万
-
财政年份:2007
-
负责人:KENNETH J. PIENTA
-
依托单位:
海外基金