International Herpesvirus Workshop

描述（由申请人提供）：本提案要求资金用于支持参加2012年在加拿大阿尔伯塔省卡尔加里举行的第37届国际疱疹病毒研讨会（IHW）的博士后和研究生的旅费和注册费。IHW是研究所有疱疹病毒的科学家的主要年度会议，已经举办了37年。这次会议非常成功，部分原因是世界主要疱疹病毒研究人员的热情参与。讲习班的优势在于通过比较不同疱疹病毒、解决关键问题的不同方法而产生的相互作用，以及该领域主要研究人员的支持和参与，最重要的是包括有前途的年轻研究人员和正在接受培训的学生。此外，该论坛是真正的国际性论坛，有广泛的世界范围的与会者。现已确认的八种人类疱疹病毒引起的疾病种类繁多，这清楚地表明了这次会议在医学上的重要性。这些疾病包括皮肤和眼睛溃疡（1型单纯疱疹病毒）、生殖器病变（2型单纯疱疹病毒）、脑膜炎和脑炎（1型单纯疱疹病毒和2型单纯疱疹病毒）、传染性单核细胞增多症（EBV）、水痘和带状疱疹（VZV）。巨细胞病毒是先天性传播导致智力迟钝、失明和耳聋等出生缺陷的主要原因，也是艾滋病患者和器官移植受者的重要机会性病原体。最近，巨细胞病毒被认为是动脉粥样硬化发生的致病因子。癌症也与疱疹病毒感染有关。EBV与伯基特淋巴瘤、其他B细胞瘤和鼻咽癌相关。最近发现的人类疱疹病毒（HHV-8或KSHV）与艾滋病患者和其他免疫抑制者以及其他群体中的卡波西肉瘤有关。所有的疱疹病毒都是终身存在的，因此对免疫功能受损的个体的治疗构成了重大问题。大多数人类疱疹病毒再激活引起的疾病是各种免疫患者群体发病率和死亡率的重要原因。研讨会将采取跨学科的方法，讨论以下主题：病毒结构，病毒进入和细胞-细胞传播的机制，膜蛋白，发病机制和潜伏期，DNA复制，疫苗接种和免疫反应，转录控制，基因表达调节，化疗靶点和病毒基因治疗。

Description (as provided by the applicant): This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 37th International Herpesvirus Workshop (IHW) in Calgary, Alberta, Canada, in 2012. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well-established in its 37th year. This meeting has been very successful, in part, because of the enthusiastic participation of the world's leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV has been implicated as pathogenic contributors in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy. Public Health Relevance: The International Herpesvirus Workshop is the premier scientific meeting for herpesvirus researchers, and the only meeting with an interdisciplinary focus on all the major subfamilies of herpesviruses and all aspects of research from molecular biology to clinical studies.