International Herpesvirus Workshop

国际疱疹病毒研讨会

• 批准号: 8593766
• 负责人: JAY A NELSON
• 金额: $ 0.4万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8593766
• 关键词: Acquired Immunodeficiency Syndrome; Animal Disease Models; Animals; Antiviral Agents; Atherosclerosis; B-Lymphocytes; Blindness; Books; Budgets; Burkitt Lymphoma; Cells; Chickenpox; Clinical Research; Communities; Congenital Abnormality; Cytomegalovirus; DNA biosynthesis; Data; Development; Disease; Educational workshop; Encephalitis; Ensure; Enzymatic Biochemistry; Eye; Fees; Fertilization; Fostering; Funding; Gene Expression Regulation; Genital system; Genome; Grant; Herpes zoster disease; Herpesviridae; Herpesviridae Infections; Herpesvirus 1; Human; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 8; Immune; Immune response; Individual; Infection; Infectious Mononucleosis; Institutes; International; Kaposi Sarcoma; Laboratories; Lesion; Life; Malignant Neoplasms; Medical; Membrane Proteins; Meningitis; Mental Retardation; Michigan; Molecular Biology; Morbidity - disease rate; Nasopharynx Carcinoma; Neoplasms; Oral; Organ Transplantation; Participant; Pathogenesis; Patients; Persons; Postdoctoral Fellow; Prevention; Publishing; Request for Proposals; Research; Research Personnel; Rest; Scientist; Skin; Structure; Students; Talents; Training; Transcriptional Regulation; Transplant Recipients; Travel; Ulcer; United States; United States National Institutes of Health; Universities; Vaccination; Viral; Viral Drug Resistance; Viral Vector; Virus; Work; abstracting; base; cost; deafness; experience; gene therapy; graduate student; immunosuppressed; interdisciplinary approach; interest; meetings; mortality; pathogen; patient population; planetary Atmosphere; posters; public health relevance; reactivation from latency; symposium; transmission process; vaccine development; virus genetics

DESCRIPTION (provided by applicant): This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 38th International Herpesvirus Workshop (IHW) in Grand Rapids, Michigan, United States, in 2013. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well-established in its 38th year. This meeting has been very successful, in part, because of the enthusiastic participation of the world's leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad- based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now-recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

描述（由申请人提供）：本提案要求资金用于支持博士后研究员和研究生参加2013年在美国密歇根州大急流城举行的第38届国际疱疹病毒研讨会（IHW）的差旅费和注册费。IHW是研究所有疱疹病毒的科学家的主要年度会议，在其第38个年头已经非常成熟。这次会议非常成功，部分原因是世界领先的疱疹病毒研究人员的热情参与。讲习班的优势在于通过比较不同的疱疹病毒、解决关键问题的不同方法以及该领域主要研究人员的支持和参与而产生的相互交流，最重要的是包括有前途的年轻研究人员和受训学生。此外，论坛是真正的国际性论坛，世界各地的与会者基础广泛。这次会议的医学重要性清楚地表明了由现在公认的八种人类疱疹病毒引起的各种疾病。这些疾病包括皮肤和眼睛溃疡（HSV-1）、生殖器病变（HSV-2）、脑膜炎和脑炎（HSV-1和HSV-2）、传染性单核细胞增多症（EBV）、水痘和带状疱疹（VZV）。巨细胞病毒是先天性传播导致的包括智力迟钝、失明和耳聋在内的出生缺陷的主要原因，但也是艾滋病患者和器官移植受者中的重要机会病原体。最近，CMV被认为是动脉粥样硬化发展中的致病因素。癌症也与疱疹病毒感染有关。EB病毒与伯基特淋巴瘤、其他B细胞肿瘤和鼻咽癌有关。最近发现的人类疱疹病毒（HHV-8或KSHV）与艾滋病患者和其他免疫抑制者以及其他人群中的卡波西肉瘤有关。所有的疱疹病毒持续存在的生活，因此造成重大问题，在治疗免疫受损的个人。由大多数人疱疹病毒的再活化引起的疾病是各种免疫患者群体中发病率和死亡率的重要原因。研讨会将采取跨学科的方法来研究以下主题：病毒结构，病毒进入和细胞-细胞传播的机制，膜蛋白，发病机制和潜伏期，DNA复制，疫苗接种和免疫反应，转录控制，基因表达调控，化疗靶点和病毒基因治疗。