Administrative

行政的

基本信息

  • 批准号:
    8405107
  • 负责人:
  • 金额:
    $ 9.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-06-22 至 2017-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY (See instructions): The proposed Project includes a complex interplay of both microbicide product development with single agent and combination microbicide products uniquely delivered to both the vaginal and rectal compartments, as well as microbicide science advancement in which the active microbicides will be utilized as tools to better understand microbicide dosing, pharmacokinetics and pharmacodynamics in explants, nonhuman primates and humans, and acceptability/user perception. The product development components consist of the dual acting entry and nonnucleoside reverse transcriptase inhibitor IQP-0528 (a pyrimidinedione with subnanomolar activity against clinical strains of HIV-1) used alone and in combination with tenofovir in dual compartment (DuoGels) gels and smart suppository/pessary (Smart Suppository) delivery vehicles that will enable dosing in both vaginal and rectal compartments. We believe the potential advancements in product development (new microbicide agents, combination products, long lasting delivery technology, dual compartment delivery technology) and microbicide science (dosing estimation, pharmacokinetics, pharmacodynamics, in vitro, ex vivo, and in vivo modeling, effects of seminal and vaginal fluids, acceptability testing methods) make this proposal both inherently novel and important to the field of microbicide science in regard to the development of the next generation of microbicide products. In whole, the Project also provides for the development of novel PK/PD assays, novel single and combination products, novel delivery strategies, and novel microbicide development advancements to better understand and prioritize the development and use of microbicide products. The Administrative Core will play a critical and essential role in ensuring the smooth integration of the various Projects and Cores included in this cooperative agreement research program. The successful performance of this Project requires a high degree of communication and interaction between the various Projects, the Cores, and the Corporate Partner. The Administrative Core will be responsible for managing and enhancing this constructive and synergistic interplay between the participating scientific groups.
项目概述(见说明):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Robert Walter Buckheit其他文献

Robert Walter Buckheit的其他文献

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{{ truncateString('Robert Walter Buckheit', 18)}}的其他基金

Critical Path IND-enabling Studies, Regulatory, and Product Development
关键路径 IND 支持研究、监管和产品开发
  • 批准号:
    8405106
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Determination of Dosing Concentrations of Formulated APIs using the MTSA
使用 MTSA 确定配方 API 的剂量浓度
  • 批准号:
    8404125
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Development and Evaluation of Dual Compartment Combination Microbicides
双室组合杀菌剂的开发与评价
  • 批准号:
    8699496
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Development and Evaluation of Dual Compartment Combination Microbicides
双室组合杀菌剂的开发与评价
  • 批准号:
    8862358
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Development and Evaluation of Dual Compartment Combination Microbicides
双室组合杀菌剂的开发与评价
  • 批准号:
    8374028
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Development and Evaluation of Dual Compartment Combination Microbicides
双室组合杀菌剂的开发与评价
  • 批准号:
    8494567
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Development and Evaluation of Dual Compartment Combination Microbicides
双室组合杀菌剂的开发与评价
  • 批准号:
    9060880
  • 财政年份:
    2012
  • 资助金额:
    $ 9.54万
  • 项目类别:
Discovery of drugs for use in the treatment and prevention of HIV infection using
发现用于治疗和预防 HIV 感染的药物
  • 批准号:
    7932473
  • 财政年份:
    2010
  • 资助金额:
    $ 9.54万
  • 项目类别:
Advanced Preclinical and Clinical Development and Regulatory Evaluations
先进的临床前和临床开发以及监管评估
  • 批准号:
    8132428
  • 财政年份:
    2010
  • 资助金额:
    $ 9.54万
  • 项目类别:
Development of Antimicrobial Peptides as Topical Microbicides
抗菌肽作为局部杀菌剂的开发
  • 批准号:
    8092553
  • 财政年份:
    2010
  • 资助金额:
    $ 9.54万
  • 项目类别:

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