Administrative Core

拟议的项目包括杀微生物剂产品开发与三个方面的复杂相互作用。 新型杀微生物剂候选物的类别，以及杀微生物剂科学的进展，其中三个 活性杀微生物剂的种类将被用作更好地理解有效杀微生物剂必须 法产品开发组件包括三类化合物， 可开发为利用凝胶和/或阴道内的单一或组合药剂的杀微生物剂潜力 环，这将允许长效杀微生物剂的开发和部署。我们相信 产品开发方面的进展（新制剂、长效输送技术）和杀微生物剂 科学（药效学，体外和离体建模，精液和阴道液的影响， 持久和组合产品的可接受性测试方法）使该建议既固有地 新的和重要的领域的杀微生物剂科学方面的发展，下一代的 杀菌剂产品。总体而言，本项目也为核心职能的履行提供了新的模式 通过增加重要的测定开发目标，以提高有效优先考虑杀微生物剂的能力 发展 行政核心将在确保顺利整合方面发挥关键而重要的作用 本合作协议研究计划中包含的各种项目和核心。成功 本项目的实施需要各方面之间的高度沟通和互动， 项目、核心和企业合作伙伴。行政核心将负责管理 并加强参与的科学团体之间的这种建设性和协同作用。

The proposed Project includes a complex interplay of both microbicide product development with three classes of novel microbicide candidates, as well as microbicide science advancement in which the three classes of active microbicides will be utilized as tools to better understand how an effective microbicide must act. The product development components consist of three classes of compounds with well documented microbicide potential that may be developed as single or combination agents utilizing gels and/or intravaginal rings that will allow long lasting microbicides to be developed and deployed. We believe the potential advancements in product development (new agents, long lasting delivery technology) and microbicide science (pharmacodynamics, in vitro and ex vivo modeling, effects of seminal and vaginal fluids, acceptability testing methods for long lasting and combination products) make this proposal both inherently novel and important to the field of microbicide science in regard to the development of the next generation of microbicide products. In whole, the Project also provides a new model for the performance of Core functions by adding important assay development objectives to improve the ability to effectively prioritize microbicide development. The Administrative Core will play a critical and essential role in ensuring the smooth integration of the various Projects and Cores included in this cooperative agreement research program. The successful performance of this Project requires a high degree of communication and interaction between the various Projects, the Cores, and the Corporate Partner. The Administrative Core will be responsible for managing and enhancing this constructive and synergistic interplay between the participating scientific groups.