Accelerated Neuro-MRA Using Compressed Sensing and Constrained Reconstruction

使用压缩感知和约束重建加速神经 MRA

• 批准号: 8252164
• 负责人: Charles A. Mistretta
• 金额: $ 34.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252164
• 关键词: Acceleration; Algorithms; Aneurysm; Angiography; Arteries; Arteriovenous malformation; Arts; Back; Blood Vessels; Bolus Infusion; Brain; Brain Aneurysms; Catheters; Cerebral Aneurysm; Cerebrovascular system; Clinical; Data; Development; Diagnosis; Diagnostic; Digital Subtraction Angiography; Disease; Drainage procedure; Early Diagnosis; Economics; Evaluation; Family; Funding; Generations; Grant; Head; Hemorrhage; Image; Imaging Device; Imaging Techniques; Imaging technology; Individual; Injection of therapeutic agent; Intravenous Bolus; Ischemic Stroke; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Morphologic artifacts; Neurologic; Noise; Patients; Performance; Physiological; Pilot Projects; Process; Protocols documentation; Radial; Resolution; Risk Factors; Roentgen Rays; Sampling; Scanning; Scheme; Series; Signal Transduction; Speed; Spin Labels; Stenosis; Stroke; Structure; Sudden Death; Techniques; Technology; Time; Veins; Venous; Venous Malformation; X-Ray Computed Tomography; abstracting; base; density; digital; human subject; image reconstruction; improved; innovation; malformation; minimal risk; nervous system disorder; next generation; novel; older patient; reconstruction; simulation; social; standard of care; time use; tool; volunteer

Abstract Magnetic resonance imaging (MRI) is the standard of care for most diagnostic neurological imaging, but with certain notable shortcomings. Cerebral aneurysms, still first often diagnosed either by sudden death or catastrophic hemorrhage, are best visualized with the resolution provided by computed tomography or digital substraction angiography (DSA). The speed of MRI is often not enough to visualize the arterial inputs and venous drainage of arterial-venous malformations (AVM). Ischemic stroke is the most common neurological disorder worldwide and intracranial arterial stenosis is a major risk factor for ischemic stroke. In order to improve confidence of diagnosis and provide early detection of the pathological changes in the cerebrovascular system, significant advances should be made towards spatial and temporal resolutions currently unavailable even with state-of-art MRA techniques. We have been developing acquisition and reconstruction methods that circumvent MRI shortcomings in speed and resolution to provide multi-dimensional physiological and anatomical information for neurovascular imaging. We have recognized that in order to achieve the required combinations of spatial and temporal resolution and signal-to-noise ratio we need to exploit the synergy of complementary advanced image acquisition and reconstruction techniques. Image estimation methods developed in our labs combine constrained reconstruction algorithms with non-Cartesian radial trajectories whose variable sampling density allows for both high quality extended scans and time-resolved imaging. We have already successfully developed the first generation of this technology known as the HYPR (HighlY constrained back Projection) family of imaging techniques, delivering substantial acceleration to the acquisition of serially acquired images. This proposal suggests a next generation of accelerated imaging technology for the comprehensive evaluation of vessel stenoses, aneurysms, and AVMs that will rival and surpass CT through the development of new image acquisition and reconstruction methods. These methods will utilize independent and symbiotic acceleration mechanisms of optimized radial trajectories, parallel imaging, and constrained reconstruction, including HYPR and advanced compressed sensing algorithms. These algorithms will also be supplied with data from novel highly accelerated acquisition methods: 1) a contrast-free inflow technique that eliminates the dispersion of contrast-enhanced bolus to provide superb arterial isolation, high resolution, and coverage; and 2) high quality time-averaged vascular image volumes to constrain reconstruction of time-resolved contrast- enhanced data. These methods will be evaluated in the treatment and tracking of AVMs, the evaluation of vascular stenoses and the evaluation of cerebral aneurysms. Successful completion would supplement the arsenal of tools used in stroke management as well.

摘要 磁共振成像(MRI)是大多数诊断神经成像的标准护理，但 一些值得注意的缺点。脑动脉瘤，仍然是第一个经常被诊断为猝死或 灾难性出血，最好用计算机断层扫描或数字成像提供的分辨率进行可视化 减影血管造影(DSA)。磁共振成像的速度通常不足以显示动脉的输入和 动静脉畸形的静脉引流。缺血性中风是最常见的神经系统疾病。 全球范围内的疾病和颅内动脉狭窄是缺血性中风的主要危险因素。为了 提高诊断的信心，及早发现本病的病变 脑血管系统，应在空间和时间分辨率方面取得重大进展 目前即使使用最先进的MRA技术也无法获得。 我们一直在开发采集和重建方法，以绕过MRI在速度上的缺点 和分辨率，为神经血管提供多维生理和解剖信息 成像。我们认识到，为了实现所需的空间和时间组合 分辨率和信噪比需要利用互补高级图像的协同作用 获取和重建技术。我们实验室开发的图像估计方法结合了 采样密度可变的非笛卡儿径向轨迹约束重建算法 支持高质量的扩展扫描和时间分辨率成像。我们已经成功地 开发了这种技术的第一代，称为HYPR(高度约束反投影) 一系列成像技术，大大加快了连续采集图像的获取速度。 这一建议为综合评估提供了下一代加速成像技术 血管狭窄、动脉瘤和动静脉畸形将通过新的开发与CT竞争并超过CT 图像采集与重建方法。这些方法将利用独立和共生 优化径向轨迹、并行成像和约束重建的加速机制， 包括HYPR和高级压缩传感算法。这些算法还将提供 来自新的高速加速采集方法的数据：1)无对比度流入技术，消除了 弥散增强对比剂，以提供极佳的动脉隔离、高分辨率和覆盖率； 2)高质量的时间平均血管图像体积，以限制时间分辨对比度的重建 增强的数据。这些方法将在动静脉畸形的治疗和跟踪中进行评估，评估 血管狭窄和脑动脉瘤的评估。成功完成将补充 阿森纳也是中风管理中使用的工具。