Accelerated Neuro-MRA Using Compressed Sensing and Constrained Reconstruction

使用压缩感知和约束重建加速神经 MRA

• 批准号: 7987640
• 负责人: Charles A. Mistretta
• 金额: $ 32.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7987640
• 关键词: Acceleration; Algorithms; Aneurysm; Angiography; Arteries; Arteriovenous malformation; Arts; Back; Blood Vessels; Bolus Infusion; Brain; Brain Aneurysms; Catheters; Cerebral Aneurysm; Cerebrovascular system; Clinical; Data; Development; Diagnosis; Diagnostic; Digital Subtraction Angiography; Disease; Drainage procedure; Early Diagnosis; Economics; Evaluation; Family; Funding; Generations; Grant; Head; Hemorrhage; Image; Imaging Device; Imaging Techniques; Imaging technology; Individual; Injection of therapeutic agent; Intravenous Bolus; Ischemic Stroke; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Morphologic artifacts; Neurologic; Noise; Patients; Performance; Physiological; Pilot Projects; Process; Protocols documentation; Radial; Resolution; Risk Factors; Roentgen Rays; Sampling; Scanning; Scheme; Series; Signal Transduction; Speed; Spin Labels; Stenosis; Stroke; Structure; Sudden Death; Techniques; Technology; Time; Veins; Venous; Venous Malformation; X-Ray Computed Tomography; base; density; human subject; image reconstruction; improved; innovation; malformation; minimal risk; nervous system disorder; next generation; novel; older patient; public health relevance; reconstruction; simulation; social; standard of care; time use; tool; volunteer

DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) is the standard of care for most diagnostic neurological imaging, but with certain notable shortcomings. Cerebral aneurysms, still first often diagnosed either by sudden death or catastrophic hemorrhage, are best visualized with the resolution provided by computed tomography or digital subtraction angiography (DSA). The speed of MRI is often not enough to visualize the arterial inputs and venous drainage of arterial-venous malformations (AVM). Ischemic stroke is the most common neurological disorder worldwide and intracranial arterial stenosis is a major risk factor for ischemic stroke. In order to improve confidence of diagnosis and provide early detection of the pathological changes in the cerebrovascular system, significant advances should be made towards spatial and temporal resolutions currently unavailable even with state-of-art MRA techniques. We have been developing acquisition and reconstruction methods that circumvent MRI shortcomings in speed and resolution to provide multi-dimensional physiological and anatomical information for neurovascular imaging. We have recognized that in order to achieve the required combinations of spatial and temporal resolution and signal-to-noise ratio we need to exploit the synergy of complementary advanced image acquisition and reconstruction techniques. Image estimation methods developed in our labs combine constrained reconstruction algorithms with non-Cartesian radial trajectories whose variable sampling density allows for both high quality extended scans and time-resolved imaging. We have already successfully developed the first generation of this technology known as the HYPR (HighlY constrained back Projection) family of imaging techniques, delivering substantial acceleration to the acquisition of serially acquired images. This proposal suggests a next generation of accelerated imaging technology for the comprehensive evaluation of vessel stenoses, aneurysms, and AVMs that will rival and surpass CT through the development of new image acquisition and reconstruction methods. These methods will utilize independent and symbiotic acceleration mechanisms of optimized radial trajectories, parallel imaging, and constrained reconstruction, including HYPR and advanced compressed sensing algorithms. These algorithms will also be supplied with data from novel highly accelerated acquisition methods: 1) a contrast-free inflow technique that eliminates the dispersion of contrast-enhanced bolus to provide superb arterial isolation, high resolution, and coverage; and 2) high quality time-averaged vascular image volumes to constrain reconstruction of time-resolved contrast- enhanced data. These methods will be evaluated in the treatment and tracking of AVMs, the evaluation of vascular stenoses and the evaluation of cerebral aneurysms. Successful completion would supplement the arsenal of tools used in stroke management as well. PUBLIC HEALTH RELEVANCE: The enormous economic and social burden of stroke demands better imaging tools to assess the cerebrovascular system. Our proposal entitled "Accelerated Neuro MRA using Compressed Sensing and Constrained Reconstruction" introduces innovative methods to safely visualize the vascular structures of the brain. Our proposed techniques have benefits over current MRA methods in that they provides greater temporal information, high spatial resolution and flow information. The techniques are of minimal risk compared to conventional catheter based X-ray angiography and are thus better suited for the evaluation of atherosclerotic disease in elderly patients. The MRA methods described in this proposal are major advances in the evaluation of patients with atherosclerotic disease, brain aneurysms and vascular malformations, which are the leading causes of stoke in the US.

描述（由申请人提供）：磁共振成像（MRI）是大多数诊断神经系统成像的护理标准，但具有某些显着的缺点。脑动脉瘤通常首先通过猝死或灾难性出血诊断，最好通过计算机断层扫描或数字减法血管造影（DSA）提供的分辨率来可视化。 MRI的速度通常不足以使动脉输入和动脉畸形（AVM）的静脉排水量不足。缺血性中风是全球最常见的神经系统障碍，颅内动脉狭窄是缺血性中风的主要危险因素。为了提高诊断的信心并提供脑血管系统病理变化的早期检测，即使使用最先进的MRA技术，也应在当前无法使用的空间和时间分辨率方面取得重大进展。我们一直在开发采集和重建方法，以绕过速度和解决方案的MRI缺点，以提供神经血管成像的多维生理和解剖学信息。我们已经认识到，为了实现空间和时间分辨率和信噪比的所需组合，我们需要利用互补的高级图像采集和重建技术的协同作用。在我们的实验室中开发的图像估计方法将受约束的重建算法与非属性径向轨迹相结合，其可变采样密度允许高质量的扩展扫描和时间分辨成像。我们已经成功地开发了该技术的第一代，即HYPR（高度受约束的背部投影）的成像技术家族，从而为获取串行获取的图像提供了实质性的加速。该提案提出了下一代加速成像技术，以全面评估血管促损，动脉瘤和AVM，通过开发新的图像采集和重建方法，该技术将与CT竞争和超越CT。这些方法将利用优化的径向轨迹，并行成像和约束重建的独立和共生加速机制，包括HYPR和高级压缩感测算法。这些算法还将提供来自新型高度加速采集方法的数据：1）一种无对比度的流入技术，消除了对比度增强的推注的分散，以提供出色的动脉隔离，高分辨率和覆盖范围； 2）高质量的时间平均的血管图像量，以限制时间分辨对比度增强数据的重建。这些方法将在AVM的治疗和跟踪，血管狭窄的评估和脑动脉瘤的评估中进行评估。成功完成将补充中风管理中使用的工具的武器库。 公共卫生相关性：中风的巨大经济和社会负担需要更好的成像工具来评估脑血管系统。我们的建议名为“使用压缩感应和约束重建的“加速神经MRA”引入了创新方法，以安全地可视化大脑的血管结构。我们提出的技术比当前的MRA方法具有好处，因为它们提供了更大的时间信息，高空间分辨率和流量信息。与传统的基于导管的X射线血管造影相比，这些技术的风险很小，因此更适合评估老年患者的动脉粥样硬化疾病。该提案中描述的MRA方法是评估动脉粥样硬化疾病，脑动脉瘤和血管畸形的患者的主要进步，这是美国斯托克的主要原因。