课题基金 / 基金详情

Basal forebrain and cognitive aging: Novel experimental and theraptutic avenues

Basal forebrain and cognitive aging: Novel experimental and theraptutic avenues
基底前脑和认知衰老：新的实验和治疗途径
批准号：
8231356
负责人：
JENNIFER Lynn BIZON
金额：
$27.75万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-08-01 至 2013-05-31
来源：
https://reporter.nih.gov/project-details/8231356
关键词：
AcetylcholineAdoptedAffectAgeAge-associated memory impairmentAgingAging-Related ProcessAlzheimer&aposs DiseaseAttenuatedBiochemicalButyric AcidsCessation of lifeCholinergic AgentsCholinergic ReceptorsClinicalClinical TreatmentCognitionCognitiveCognitive agingCognitive deficitsConfocal MicroscopyDataDiagnosisDiscriminationDiscrimination LearningDiseaseEarly DiagnosisElderlyExhibitsExperimental DesignsFunctional disorderGABA AgentsGABA-B ReceptorHippocampus (Brain)HomeostasisHumanImpaired cognitionImpairmentIndividualIndividual DifferencesInvestigationLaboratoriesLearningLongevityMeasuresMedialMemoryMemory LossModelingMorphologyMuscarinic Acetylcholine ReceptorMuscarinicsNeurobiologyNeuronal DysfunctionNeuronsOdorsPathway interactionsPerformancePharmaceutical PreparationsPhenotypePopulationPreparationProcessPropertyProteinsQuality of lifeRattusReceptor SignalingRegimenReportingReproducibilityResearchResearch PersonnelRodentRodent ModelShort-Term MemorySignal TransductionSliceStagingStructureSynapsesSynaptic TransmissionSystemTechniquesTemporal LobeTestingTimeTrainingUnited Statesage relatedagedbasal forebraincholinergiccholinergic neuroncognitive functioncohorteffective therapyefficacy testingexpectationgamma-Aminobutyric Acidimprovedinhibitor/antagonistinterestmalemiddle agemild neurocognitive impairmentneural circuitnovelprogramsreceptorreceptor expressionreceptor functiontransmission processyoung adult

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