RAPID FIELD TEST FOR IODINE LEVELS IN SALT

盐中碘含量的快速现场测试

• 批准号: 8904051
• 负责人: BIKAS VAIDYA
• 金额: $ 48.54万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8904051
• 关键词: Address; Adopted; Africa; Asia; Back; Biological Markers; Calibration; Chemicals; Child; Collaborations; Color; Community Health; Consumption; Country; County; Detection; Developed Countries; Developing Countries; Devices; Disease; Ensure; Evaluation; Face; Far East; Feedback; Fetus; Film; Health; Housing; Hypothyroidism; Individual; Infant; International; International Agencies; Intervention; Interview; Iodides; Iodine; Laboratories; Latin America; Letters; Liquid substance; Logistics; Mental Retardation; Methods; Monitor; Optical Readers; Optics; Performance; Persons; Phase; Population; Pregnant Women; Procedures; Production; Program Development; Property; Reader; Reading; Reagent; Research; Research Infrastructure; Resources; Risk; Rural; Shipping; Ships; Site; Small Business Innovation Research Grant; Sodium Chloride; Solutions; South Africa; Staging; Testing; Training; UNICEF; United States National Institutes of Health; Validation; Work; chemical reaction; combat; commercialization; cost; design; dietary salt; fortification; hazard; intervention program; iodine deficiency syndrome; iodized salt; member; mental development; nutrition; operation; prevent; programs; prototype; reagent testing; rural area

DESCRIPTION (provided by applicant): Nearly 2 billion people (mostly in Africa, South East Asia and Latin America) have inadequate iodine nutrition. Pregnant women and children are most at risk from iodine deficiency disorders (IDD), which occur as a range of abnormalities including hypothyroidism which impairs mental development in the fetus and in infants. Iodine deficiency disorders have been greatly reduced in industrialized countries through routine addition of iodine to table salt, a practice that started in the 1920's. Recently, the internationa health community has been striving to implement salt iodization programs in the rural areas of developing counties where the populations remain at risk from IDD. There are many challenges. Developing countries are typically served by a network of individual artisanal salt producers using low tech production methods and poorly administered distribution channels. In these situations international and regional health agencies need viable methods to check salt iodine levels in the field at multiple salt production sites and at points along the distribution chain. Laboratory test methods cannot be used in these situations and existing test kits for iodine have significant limitations. Lacking critical information whether their efforts to introduce iodine int salt at the prescribed levels are succeeding, IDD intervention programs can become ineffective or breakdown entirely. Working with coordinators from the International Council for the Control of Iodine Deficiency Disorders (ICCIDD) we have devised a salt iodine test kit specifically for low resource (rural) settings in developing countries. The test kit uses dry (stable) test reagents tha are incorporated into a uniquely layered multi- reagent cartridge. A chemical reaction sequence is essentially "programmed" into the cartridge eliminating user intervention and the need to handle liquid reagents. Additional merits include: detection of both iodine and iodate over the required range (5-100 ppm), the cartridges and associated reader are low cost items and easy to produce on a large scale. This Phase II proposal describes research necessary to transition the test kit into a functional prototype and includes provision for independent evaluation and feedback from international experts on iodine deficiency disorders.

描述（由申请人提供）：近20亿人（主要在非洲、东南亚和拉丁美洲）碘营养不足。孕妇和儿童最容易患缺碘症，缺碘症表现为一系列异常，包括甲状腺功能减退，损害胎儿和婴儿的智力发育。在工业化国家，通过在食盐中常规添加碘，碘缺乏症已大大减少，这种做法始于1920年代。近年来，国际卫生界一直在努力在发展中国家的农村地区实施食盐加碘计划，这些地区的人口仍然面临碘缺乏病的危险。有许多挑战。发展中国家通常由个体手工盐生产商网络提供服务，这些个体手工盐生产商使用低技术生产方法和管理不善的分销渠道。在这些情况下，国际和区域卫生机构需要可行的方法来检查多个盐生产地点和分销链沿着点的盐碘水平。在这些情况下不能使用实验室检测方法，现有的碘检测试剂盒有很大的局限性。由于缺乏关键信息，他们在规定水平的盐中引入碘的努力是否成功，碘缺乏病干预计划可能变得无效或完全崩溃。我们与控制碘缺乏病国际理事会的协调员合作，设计了一种专门用于低碘人群的盐碘检测试剂盒。 发展中国家的资源（农村）环境。该检测试剂盒使用干燥（稳定）的检测试剂，这些试剂被纳入一个独特的多层试剂盒中。化学反应序列基本上被“编程”到盒中，从而消除了用户干预和处理液体试剂的需要。其他优点包括：检测所需范围（5-100 ppm）内的碘和碘酸盐，盒和相关的读出器是低成本的物品并且易于大规模生产。这一第二阶段的建议说明了将测试包转变为功能原型所需的研究，并包括由国际缺碘症专家进行独立评价和反馈的规定。