RAPID FIELD TEST FOR IODINE LEVELS IN SALT

盐中碘含量的快速现场测试

基本信息

批准号：
8904051
负责人：
BIKAS VAIDYA
金额：
$ 48.54万
依托单位：
LYNNTECH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-15 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8904051
关键词：
Address Adopted Africa Asia Back Biological Markers Calibration Chemicals Child Collaborations Color Community Health Consumption Country County Detection Developed Countries Developing Countries Devices Disease Ensure Evaluation Face Far East Feedback Fetus Film Health Housing Hypothyroidism Individual Infant International International Agencies Intervention Interview Iodides Iodine Laboratories Latin America Letters Liquid substance Logistics Mental Retardation Methods Monitor Optical Readers Optics Performance Persons Phase Population Pregnant Women Procedures Production Program Development Property Reader Reading Reagent Research Research Infrastructure Resources Risk Rural Shipping Ships Site Small Business Innovation Research Grant Sodium Chloride Solutions South Africa Staging Testing Training UNICEF United States National Institutes of Health Validation Work chemical reaction combat commercialization cost design dietary salt fortification hazard intervention program iodine deficiency syndrome iodized salt member mental development nutrition operation prevent programs prototype reagent testing rural area

项目摘要

DESCRIPTION (provided by applicant): Nearly 2 billion people (mostly in Africa, South East Asia and Latin America) have inadequate iodine nutrition. Pregnant women and children are most at risk from iodine deficiency disorders (IDD), which occur as a range of abnormalities including hypothyroidism which impairs mental development in the fetus and in infants. Iodine deficiency disorders have been greatly reduced in industrialized countries through routine addition of iodine to table salt, a practice that started in the 1920's. Recently, the internationa health community has been striving to implement salt iodization programs in the rural areas of developing counties where the populations remain at risk from IDD. There are many challenges. Developing countries are typically served by a network of individual artisanal salt producers using low tech production methods and poorly administered distribution channels. In these situations international and regional health agencies need viable methods to check salt iodine levels in the field at multiple salt production sites and at points along the distribution chain. Laboratory test methods cannot be used in these situations and existing test kits for iodine have significant limitations. Lacking critical information whether their efforts to introduce iodine int salt at the prescribed levels are succeeding, IDD intervention programs can become ineffective or breakdown entirely. Working with coordinators from the International Council for the Control of Iodine Deficiency Disorders (ICCIDD) we have devised a salt iodine test kit specifically for low resource (rural) settings in developing countries. The test kit uses dry (stable) test reagents tha are incorporated into a uniquely layered multi- reagent cartridge. A chemical reaction sequence is essentially "programmed" into the cartridge eliminating user intervention and the need to handle liquid reagents. Additional merits include: detection of both iodine and iodate over the required range (5-100 ppm), the cartridges and associated reader are low cost items and easy to produce on a large scale. This Phase II proposal describes research necessary to transition the test kit into a functional prototype and includes provision for independent evaluation and feedback from international experts on iodine deficiency disorders.

描述（由申请人提供）：近20亿人（主要在非洲，东南亚和拉丁美洲）的碘营养不足。孕妇和儿童受到碘缺陷障碍（IDD）的最大风险，这些疾病是一系列异常，包括甲状腺功能减退症，这些甲状腺功能减退症会损害胎儿和婴儿的智力发育。工业化国家的碘缺陷障碍通过常规添加碘盐大大降低，这种做法始于1920年代。最近，国际卫生社区一直在努力在发展县的农村地区实施盐碘化计划，在这些县的农村地区仍处于IDD的危险中。有很多挑战。发展中国家通常使用低技术生产方法和管理较差的分销渠道的单个手工盐生产商网络提供服务。在这些情况下，国际和地区卫生机构需要可行的方法来检查多个盐生产地点和分销链沿线的盐碘水平。在这些情况下不能使用实验室测试方法，现有的碘测试套件具有重大局限性。缺乏关键信息是否成功地引入碘含量，IDD干预计划可能会变得无效或完全分解。与国际碘缺陷障碍控制委员会（ICCIDD）的协调员合作，我们设计了一个专门针对低的盐碘测试套件发展中国家的资源（农村）环境。测试套件使用干燥（稳定）测试试剂THA被掺入独特的分层多试剂盒中。化学反应序列本质上被“编程”到消除用户干预和处理液体试剂的需要中。其他优点包括：在所需范围（5-100 ppm）上碘和碘的检测，墨盒和相关的读者是低成本的项目，易于大规模生产。该第二阶段的建议描述了将测试套件转换为功能原型所必需的研究，并提供了针对国际缺乏障碍的国际专家的独立评估和反馈的规定。