How lipids affect signalling efficiencies in T cells

脂质如何影响 T 细胞的信号传导效率

• 批准号: nhmrc : 1022182
• 负责人: Dr Jeremie Rossy
• 金额: $ 31.53万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipids-affect-signalling-t-cells/110171
• 关键词: How; lipids; affect; signalling; efficiencies

A high fat diet can compromise the function our immune system. This project examines how lipids affect T cells. We propose that T cells from mice on a high fat diet can no longer respond to an immune challenge because the signalling processes that lead to activation are deregulated. We have established a new microscopy technique that allows us to measure the efficiency of signalling processes. We will use this method to identify which lipids contribute the most to T cell deregulation.

高脂肪饮食会损害我们免疫系统的功能。这个项目研究脂质如何影响T细胞。我们提出，高脂肪饮食小鼠的T细胞不能再对免疫挑战做出反应，因为导致激活的信号过程被解除了管制。我们已经建立了一种新的显微镜技术，使我们能够测量信号传递过程的效率。我们将使用这种方法来确定哪些脂质对T细胞解除管制贡献最大。