Prion-like behaviour in immunity: super-sized signalling platforms?

免疫中类似朊病毒的行为：超大信号平台？

• 批准号: nhmrc : 1108859
• 负责人: Dr Jeremie Rossy
• 金额: $ 41.96万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/prion-like-behaviour-signalling-platforms/663061
• 关键词: Prion; like; behaviour; immunity; super

Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.

朊病毒大多与病理学有关，但最近的发现表明朊病毒样行为可能是有益的，例如增强我们的免疫反应。为了验证这一点，我们希望系统地探索所有参与防御病原体的人类蛋白质，发现新的朊病毒样趋势，并探索它们在先天免疫反应中的作用。