A signalling endosomal network in T cell activation

T 细胞激活中的信号传导内体网络

• 批准号: nhmrc : GNT1102730
• 负责人: Dr Jeremie Rossy
• 金额: $ 42.8万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signalling-endosomal-network-cell-activation/1346236
• 关键词: signalling; endosomal; network; cell; activation

T lymphocytes play a central role in the adaptive immune response, which specifically targets pathogens and cancer cells and creates the immunological memory. Activation of sometimes as little as one single receptor on a T cell triggers a cellular signal that rapidly expands and branches out in a multitude of sub-signals. Here we will use a combination of novel microscopy approaches to visualise how a network of dedicated intracellular compartments is in charge of these processes.

T淋巴细胞在适应性免疫反应中发挥核心作用，特异性地针对病原体和癌细胞并产生免疫记忆。有时激活T细胞上的单个受体就会触发细胞信号，该信号迅速扩展并分支出许多子信号。在这里，我们将使用新型显微镜方法的组合来可视化一个专门的细胞内隔室网络是如何负责这些过程的。