CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8365053
• 负责人: HENRY N GINSBERG
• 金额: $ 45.91万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365053
• 关键词: Acquired Immunodeficiency Syndrome; Award; Clinical Sciences; Research; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches; a novel, 2-phase inter- disciplinary pilot award program that has already captured several NIH grants; a Website for all service request that also has a faculty directory that facilitates collaborative research; 5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications; collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services; successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols; opening of the Columbia Community Partnership for Health center, one-half mile from CUMC. as a home for community-based organizations and community- based participatory research; launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding; and transformation of the "old" GCRC core laboratory into a campus-wide biomarkers core serving T1, T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed for T2 and T3 clinical researchers; (2) Capitalize on CUMC's outstanding T1 discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for comparative effectiveness research. PUBLIC HEALTH RELEVANCE (provided by applicant): The Clinical and Translational Science Award (CTSA) allow Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 描述(由申请者提供)：哥伦比亚大学医学中心(CUMC)CTSA和欧文临床与翻译研究所(IICTR)利用10个关键资源中的教师的专业知识和承诺，在转变CUMC临床和翻译(C/T)研究文化的目标上取得了显著进展。例子包括：使用跨学科方法的新项目；已经获得了几项NIH赠款的新颖的两阶段跨学科试点奖励计划；针对所有服务请求的网站，该网站还具有促进合作研究的教师名录；为600多名研究人员提供5小时的免费咨询，导致33项NIH赠款和106篇出版物；几个CUMC监管小组之间的合作，显著改善了合同、IRB审批时间和道德教育/咨询服务；在ICU和ED成功发射卫星研究设施，导致50名新的研究人员进行30项新的方案；哥伦比亚社区健康伙伴中心，距离CUMC半英里。作为社区组织和社区参与性研究的发源地；在现有的T32项目中推出了新的POR硕士学位，一个新的一年制证书课程，以及一个出色的KL2项目，其中9名学者已经获得了独立资金；以及将“旧的”GCRC核心实验室改造成一个服务于T1、T2和T3研究人员的校园范围的生物标志物核心。在整个过程中，我们的跟踪和评价小组就未来方向提供了重要协助。最重要的是，我们已经验证了CTSA的概念，并正在改变CUMC的研究文化。在接下来的4年里，在每年近400万美元的机构支持下，我们将在此基础上再接再厉，(1)扩大我们为T2和T3临床研究人员开发的资源和基础设施；(2)通过将现有资源和研究人员更紧密地整合到我们的CTSA中，利用CUMC出色的T1发现研究社区。(3)通过与NYPH门诊护理网络和以社区为基础的组织合作，开发比较效果研究的平台，改善我们社区的健康。 公共卫生相关性(由申请者提供)：临床和转化科学奖(CTSA)允许哥伦比亚大学支持旨在加快将实验室取得的科学发现转化为新疗法的新项目。CTSA将确保这些新疗法被执业医生和社区成员接受，以便我们能够开始显著改善我们社区和国家的健康。