CLINICAL AND TRANSLATIONAL SCIENCE AWARD

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 用于该研究领域的基础设施，而不是直接提供的资金 向子项目或子项目工作人员提供NCRR补助金。 描述（由申请人提供）：哥伦比亚大学医学中心（Columbia University Medical Center）的CTSA和欧文临床和转化研究所（IICTR），利用10个关键资源中教师的专业知识和承诺，朝着转变临床和转化（C/T）研究文化的目标取得了显著进展。示例包括：使用跨学科方法的新项目; 2一个新的，2阶段的跨学科试点奖励计划，已经获得了几个NIH补助金; 3一个网站，为所有服务的要求，也有一个教师目录，促进合作研究; 4 5个小时的免费咨询，以超过600名调查人员导致33个NIH补助金和106出版物;几个CNOC监管小组之间的合作，显著改善了合同签订、IRB批准时间和伦理教育/咨询服务;成功发射了ICU和ED的卫星研究设施，导致50名新研究人员执行30项新方案;哥伦比亚社区健康合作中心开幕，距离哥伦比亚大学半英里。作为以社区为基础的组织和以社区为基础的参与式研究的家园;在POR中推出新的硕士学位，在现有的T32课程中推出一个为期一年的新证书课程，以及一个杰出的KL2课程，其中9名学者已经获得了独立的资金;并将“旧”GCRC核心实验室转变为校园范围内的生物标志物核心，为T1，T2和T3研究人员服务。在整个过程中，我们的跟踪和评价小组就今后的方向提供了至关重要的协助。最重要的是，我们已经验证了CTSA的概念，并正在改变CNOC的研究文化。在接下来的4年里，每年近400万美元的机构支持，我们将在此基础上（1）扩大我们为T2和T3临床研究人员开发的资源和基础设施;（2）通过将现有资源和研究人员更紧密地整合到我们的CTSA中，充分利用CNOC杰出的T1发现研究社区。(3)通过与NYPH门诊护理网络和社区组织合作，为比较有效性研究开发平台，改善我们社区的健康状况。 公共卫生相关性（由申请人提供）：临床和转化科学奖（CTSA）允许哥伦比亚大学支持新的项目，其目标是加快实验室中的科学发现转化为新的疗法。CTSA将确保这些新疗法被执业医生和社区成员接受，这样我们就可以开始显著改善我们社区和国家的健康。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches; a novel, 2-phase inter- disciplinary pilot award program that has already captured several NIH grants; a Website for all service request that also has a faculty directory that facilitates collaborative research; 5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications; collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services; successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols; opening of the Columbia Community Partnership for Health center, one-half mile from CUMC. as a home for community-based organizations and community- based participatory research; launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding; and transformation of the "old" GCRC core laboratory into a campus-wide biomarkers core serving T1, T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed for T2 and T3 clinical researchers; (2) Capitalize on CUMC's outstanding T1 discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for comparative effectiveness research. PUBLIC HEALTH RELEVANCE (provided by applicant): The Clinical and Translational Science Award (CTSA) allow Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.