CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

CTSA 临床试验基础设施

• 批准号: 8365050
• 负责人: HENRY N GINSBERG
• 金额: $ 408.27万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365050
• 关键词: Award; Clinical Sciences; Clinical Trials; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches; a novel, 2-phase inter- disciplinary pilot award program that has already captured several NIH grants; a Website for all service request that also has a faculty directory that facilitates collaborative research; 5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications; collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services; successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols; opening of the Columbia Community Partnership for Health center, one-half mile from CUMC. as a home for community-based organizations and community- based participatory research; launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding; and transformation of the "old" GCRC core laboratory into a campus-wide biomarkers core serving T1, T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed for T2 and T3 clinical researchers; (2) Capitalize on CUMC's outstanding T1 discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for comparative effectiveness research. PUBLIC HEALTH RELEVANCE (provided by applicant): The Clinical and Translational Science Award (CTSA) allow Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 描述（由申请人提供）：哥伦比亚大学医学中心（CUMC）CTSA和欧文临床和转化研究所（IICTR），利用教师在10个关键资源中的专业知识和承诺取得了重大进展，以转化CUMC的临床和翻译文化（C/T）研究。示例包括：使用跨学科方法的新型项目；一项小说，2阶段的纪律试验奖计划，已经获得了几项NIH赠款；所有服务请求的网站，该网站还具有一个教职员工目录，可促进合作研究；向600多名调查人员提供5个小时的免费咨询，导致33个NIH赠款和106个出版物；几个CUMC监管团体之间的合作，这些组织大大改善了收缩，IRB批准和道德教育/咨询服务；成功推出了ICU和EDS的卫星研究设施，导致50名新调查人员进行了30种新协议；哥伦比亚社区合作伙伴卫生中心的开放，距CUMC一半英里。作为社区组织和基于社区的参与性研究的家；在POR上启动了新的硕士学位，现有T32计划中的一年一年证书课程，以及一个出色的KL2计划，其中9名学者已经获得了独立的资金；以及将“旧” GCRC核心实验室转变为校园范围内的生物标志物核心，为T1，T2和T3调查人员提供服务。在整个过程中，我们的跟踪和评估小组为未来方向提供了关键的帮助。最重要的是，我们已经验证了CTSA的概念，并正在改变CUMC的研究文化。在接下来的4年中，在每年近400万美元的机构支持下，我们将建立在这个基金会的基础上，并（1）扩展我们为T2和T3临床研究人员开发的资源和基础设施； （2）通过将现有资源和研究人员更加紧密地集成到我们的CTSA中，利用CUMC出色的T1发现研究社区。 （3）通过与NYPH卧床护理网络和基于社区的组织合作，为比较有效性研究开发平台，从而改善我们社区的健康状况。 公共卫生相关性（由申请人提供）：临床和转化科学奖（CTSA）允许哥伦比亚大学支持新计划，其目标是加快实验室在新疗法中的科学发现的翻译。 CTSA将确保这些新疗法被执业医师和社区成员所接受，以便我们可以显着改善社区和国家的健康。